CD200, a “no danger” signal for hair follicles

Rosenblum, Michael D.; Yancey, Kim B.; Olasz, Edit; Truitt, Robert L.

doi:10.1016/j.jdermsci.2005.11.003

Cited by 70 publications

(94 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, our data suggest a novel role for HSP-27 as an MO anti-danger signal down-modulating innate and adaptive immunity similar to the role suggested for CD200 [49]. The HSP-27 effect on MO differentiation to DC or MU also appears to involve TLR4 triggering.…”

Section: Discussionsupporting

confidence: 50%

“…This could be beneficial in cases when HSP-27 release is the result of extensive tissue damage and accompanied by release of degraded self proteins which could trigger auto-immunity. HSP-27 may be part of a natural system of endogenous proteins that return immune responses to quiescence [42,49]. However, HSP-27-mediated inhibition of MO?iDC differentiation and subsequent DC activation of T cells may also be pathologically dampening immune responses to tumor antigens.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells

Laudański

Miller-Graziano

2007

Eur J Immunol

View full text Add to dashboard Cite

Circulating heat shock protein (HSP)‐27 is associated with tumor progression and increased post‐injury infection. Extracellular HSP‐27 might alter monocyte (MO)‐derived DC and/or MΦ function to mediate immunosuppression. HSP‐27 treatment inhibited expression of CD1a and CD1b/c, antigen uptake, and allogeneic T cell induction (MLR) by IL‐4 + GM‐CSF‐differentiated human DC while increasing some MΦ characteristics (↑CD14, ↑CD16, ↑CD163). MO cytokine receptor profiles elicited by 24‐h exogenous HSP‐27 treatment remained supportive of immature DC (iDC) emergence (↑IL‐4R, ↓IL‐6R, ↓M‐CSFR). IL‐10, IL‐6, and M‐CSF (which promote MΦ differentiation) were significantly increased in IL‐4 + GM‐CSF + HSP‐27 MO→iDC differentiation cultures. However, HSP‐27 treatment during MO differentiation to DC increased programmed cell death ligand 1 coinhibitor and depressed CD86 costimulator expression in parallel to decreased iDC MLR activity. This suggested that increased MΦ differentiation was not solely responsible for HSP‐27 reduction of differentiating DC activity. HSP‐27 treatment actually depressed the phagocytic capacity of MO differentiated to MΦ by IL‐10 or M‐CSF culture. CD163 (hemoglobin receptor) expression was depressed on M‐CSF + HSP‐27 MO‐derived MΦ. HSP‐27‐mediated inhibition of MO→iDC differentiation was reversed by p38α & β inhibitor (SB202190) addition or TLR4 receptor modulation. HSP‐27 impaired appropriate MO→iDC and MO→MΦ differentiation modulating expression of receptors necessary for their proper functions. This suggests that endogenous HSP‐27 has immunoregulatory activities which could contribute to immunopathology.

show abstract

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells

Laudański

Miller-Graziano

2007

Eur J Immunol

View full text Add to dashboard Cite

show abstract

“…Membranöz bir glikoprotein olan CD200'ün bu bölgedeki keratinositlere immün sistem için "tehlikesizdir" özelliğini kazandıran anahtar bir molekül olduğu öne sürülmektedir. Böylece kıl folikülü tümsek hücrelerinde CD200 ekspresyonundaki azalmanın bu bölgenin immün tolerans özelliğinin kalkmasına neden olacağı ve dolayısıyla skatrisyel alopesi gelişebileceği PSA'lar için bir başka alternatif hipotez oluşturmuştur (23,24). Biz çalışmamızda hafif düzeydeki CD200 boyanmayı, hemen tümsek altı bölgedeki DKK hücrelerinde saptadık.…”

Section: Discussionunclassified

“…CK15'e ek olarak CD34, nestin ve CD200 kıl folikülü tümseğindeki keratinositlerde ekspre edilmesiyle bu anatomik lokalizasyonu belirlemek için kullanılan diğer belirteçlerdir (7)(8)(9)(10).…”

Section: Introductionunclassified

Expressions of CK15, CD34, Nestin and CD200 in Lichen Planopilaris

Dicle¹,

Özenci²,

Sahin³

et al. 2017

tdd

View full text Add to dashboard Cite

Objective: The etiopathogenesis of lichen planopilaris is not known well and and it is thought that inflammatory infiltrate heads towards to the region adjacent to stem cells on bulge region of pilosebaceous unit. In this study, it was aimed to describe CK15, CD34, nestin and CD200 expression patterns in patients with lichen planopilaris in order to contribute describing which parts or cell types in the follicle were damaged. Methods: In this study, affected and healthy scalp specimens of 10 lichen planopilaris patients and scalp specimens of 9 patients undergoing surgical excisions due to sebaceous cysts were included. Routine immunohistochemical analysis of CK15, CD34, nestin and CD200 primer antibodies were performed to all tissue samples. Stained slides were graded according to expression intensity from no expression (-) to strong expression (++). Results: CK15, CD34 and CD200 expression patterns were similar in controls and patient lesional samples. Nestin expression only decreased in the sub-bulge area in patient lesional samples. Conclusion:The absence of apparent differences in the CK15, CD34, nestin and CD200 expressions of affected scalp samples of patients suggests that these markers may display different expressions at different stages of the hair follicle cycle and cell differentiation and further studies are necessary to figure out whether these expressions are changed with the activity of the disease. Keywords: Alopecia, lichen planopilaris, CK15, CD34, CD200, nestin Amaç: Liken planopilarisde etyopatogenez henüz tam olarak bilinmemekte, inflamasyonun pilosebase ünitenin tümsek bölgesindeki kök hücrelere bitişik bölgesine yönlendiği düşünülmektedir. Bu çalışmada liken planopilarisde folikülde hangi bölgelerin, ya da hangi yapıdaki hücrelerin hasara uğradığını açıklamaya katkıda bulunmak amacıyla CK15, CD34, nestin ve CD200 immünohistokimyasal ekspresyon paternlerini tanımlamak hedeflenmiştir. Yöntemler: Çalışmaya klinik ve histopatolojik olarak liken planopilaris tanısı almış 10 hastanın sağlam ve hastalıklı saçlı deri örnekleri ve saç hastalığı bulunmayan, sebase kist nedeniyle cerrahi operasyon geçirmiş 9 kişiden elde edilen saçlı deri doku örnekleri alındı. Tüm örneklere CK15, CD34, nestin ve CD200 primer antikorları ile rutin immünohistokimyasal işlem uygulandı. Boyanmış kesitler ekspresyon şiddeti; ekspresyon yok (-) ile kuvvetli ekspresyon (++) arasında derecelendirildi. Bulgular: CK15, CD34 ve CD200 ekspresyon paterni kontroller ve hasta örneklerinde benzerdi. Nestin ekspresyonu hasta örneklerinde sadece tümsek altı bölgede daha zayıftı. Sonuç: CK15, CD34, nestin ve CD200 ekspresyonlarında hasta örneklerinde belirgin farklılıklar göstermemesi, bu belirteçlerin kıl folikülü siklusunun farklı evrelerinde ve hücre differansiyasyonlarına göre farklı ekspresyonlar gösterebileceğini ve hastalığın aktivitesi ile ilişkili ekspresyonların değişip değişmediğinin daha geniş serilerde değerlendirilmesi gerektirdiğini düşündürmüştür.

show abstract

“…A correlation has been observed between these different susceptibilities and histologic/molecular profiles in intestinal tissue in these two combinations. CD200 expression has also been found to regulate inflammation in the hair follicles of the skin [4,126]. CD200 is expressed on Langerhans cells (LCs) and keratinocytes (KCs) in mouse epidermis, and skin in CD200KO mice is susceptible to hair follicle inflammation and immune-mediated alopecia, suggesting that CD200:CD200R interactions attenuate perifollicular inflammation and may protect epidermal stem cells from autoimmune destruction.…”

Section: Regulation Of Autoimmune Disease By Cd200:cd200rmentioning

confidence: 99%

CD200:CD200R-Mediated Regulation of Immunity

Gorczynski

2012

ISRN Immunology

View full text Add to dashboard Cite

The type 1 membrane glycoprotein CD200, widely expressed on multiple cells/tissues, uses a structurally similar receptor (CD200R1), whose expression is more restricted to cells of the myeloid and lymphoid lineages, to transmit signals affecting responses in multiple physiological systems. Thus CD200 expression is reported to exert effects on cancer growth, autoimmune and allergic disorders, infection, transplantation, bone development and homeostasis, and reproductive biology. It was initially thought, based on the idea that CD200R1 was mostly expressed on cells of myeloid origin, that CD200:CD200R1 interactions were primarily dedicated to controlling myeloid cell function. However additional members of the CD200R family have now also been identified, although their function(s) remain unclear, and CD200R1 itself is now known to be expressed by subsets of T cells and other cells. Together these observations add layers of complexity to our understanding of CD200-related regulation. In common with a number of physiological systems, the mechanism(s) of CD200-induced signaling seem to fit within a similar framework of opposing actions of kinases and phosphatases. This paper highlights the advances in our knowledge of immunoregulation achieved following CD200:CD200R interaction and the potential clinical applicability of that information.

show abstract

CD200, a “no danger” signal for hair follicles

Cited by 70 publications

References 35 publications

Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells

Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells

Expressions of CK15, CD34, Nestin and CD200 in Lichen Planopilaris

CD200:CD200R-Mediated Regulation of Immunity

Contact Info

Product

Resources

About