CD20+ T cell numbers are decreased in untreated HIV-1 patients and recover after HAART

Förster, Friederike; Singla, Anuj; Arora, Sunil; Schmidt, Reinhold; Jacobs, Roland

doi:10.1016/j.imlet.2012.05.004

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…Consistent with the decreased frequency of CD3 + CD20 + cells in patients with HIV, 8 CD3 + CD19 + cells were also less abundant in the Mtb and HIV‐ Mtb co‐infection groups than in the HCs. Moreover, a marked variation in the frequency of T and B cells was noted in the three infected groups, while a slight variation in the frequency of CD3 + CD19 + cells was noted in the three infected groups.…”

Section: Figuresupporting

confidence: 65%

Discovery of CD3⁺CD19⁺ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

Wang

Zhang

et al. 2021

Clinical & Translational Med

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Section: Figuresupporting

confidence: 65%

Discovery of CD3⁺CD19⁺ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

Wang

Zhang

et al. 2021

Clinical & Translational Med

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“…Recent data provided strong evidence that compartmentalization of T and other cells, such as B cells, is not absolute: violators of this paradigm can indeed be generated under specific conditions ( 92 – 95 ). CD20-expressing T cell populations have been found in healthy individuals as well as in a variety of non-malignant disease states ( 92 , 94 , 96 – 100 ).…”

Section: Discussionmentioning

confidence: 99%

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues

et al. 2021

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CD4 T cell responses constitute an important component of adaptive immunity and are critical regulators of anti-microbial protection. CD4+ T cells expressing CD32a have been identified as a target for HIV. CD32a is an Fcγ receptor known to be expressed on myeloid cells, granulocytes, B cells and NK cells. Little is known about the biology of CD32+CD4+ T cells. Our goal was to understand the dynamics of CD32+CD4+ T cells in tissues. We analyzed these cells in the blood, lymph nodes, spleen, ileum, jejunum and liver of two nonhuman primate models frequently used in biomedical research: African green monkeys (AGM) and macaques. We studied them in healthy animals and during viral (SIV) infection. We performed phenotypic and transcriptomic analysis at different stages of infection. In addition, we compared CD32+CD4+ T cells in tissues with well-controlled (spleen) and not efficiently controlled (jejunum) SIV replication in AGM. The CD32+CD4+ T cells more frequently expressed markers associated with T cell activation and HIV infection (CCR5, PD-1, CXCR5, CXCR3) and had higher levels of actively transcribed SIV RNA than CD32-CD4+T cells. Furthermore, CD32+CD4+ T cells from lymphoid tissues strongly expressed B-cell-related transcriptomic signatures, and displayed B cell markers at the cell surface, including immunoglobulins CD32+CD4+ T cells were rare in healthy animals and blood but increased strongly in tissues with ongoing viral replication. CD32+CD4+ T cell levels in tissues correlated with viremia. Our results suggest that the tissue environment induced by SIV replication drives the accumulation of these unusual cells with enhanced susceptibility to viral infection.

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“…These CD20 + T cells display a distinct phenotype compared to the majority of CD20 − T cells, with an increased percentage of CD8 + and CD45RO + cells [9]. CD20 + T cells represent a highly activated cell population, characterized by enhanced production of proinflammatory cytokines (e.g., tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and interleukin-17 (IL-17)) constitutively as well as upon activation [10,11,12]. These cells are found in blood, cerebrospinal fluid (CSF), and chronic brain lesions of MS patients [12,13].…”

Section: Introductionmentioning

confidence: 99%

Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients

Gingele

Jacobus

Konen

et al. 2018

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109

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Ocrelizumab, a humanized monoclonal anti-CD20 antibody, has shown pronounced effects in reduction of disease activity in multiple sclerosis (MS) patients and has recently been approved for the treatment of patients with relapsing MS (RMS) and primary progressive MS (PPMS). CD20 is mainly expressed by B cells, but a subset of T cells (CD3+CD20+ T cells) also expresses CD20, and these CD20+ T cells are known to be a highly activated cell population. The blood of MS patients was analyzed with multicolor flow cytometry before and two weeks after treatment with ocrelizumab regarding the phenotype of peripheral blood mononuclear cells. CD20-expressing CD3+ T cells were found in blood samples of all MS patients, accounted for 2.4% of CD45+ lymphocytes, and constituted a significant proportion (18.4%) of all CD20+ cells. CD3+CD20+ T cells and CD19+CD20+ B cells were effectively depleted two weeks after a single administration of 300 mg ocrelizumab. Our results demonstrate that treatment with ocrelizumab does not exclusively target B cells, but also CD20+ T cells, which account for a substantial amount of CD20-expressing cells. Thus, we speculate that the efficacy of ocrelizumab might also be mediated by the depletion of CD20-expressing T cells.

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CD20+ T cell numbers are decreased in untreated HIV-1 patients and recover after HAART

Cited by 11 publications

References 11 publications

Discovery of CD3⁺CD19⁺ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

Discovery of CD3⁺CD19⁺ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues

Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients

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CD20+ T cell numbers are decreased in untreated HIV-1 patients and recover after HAART

Cited by 11 publications

References 11 publications

Discovery of CD3+CD19+ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

Discovery of CD3+CD19+ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues

Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients

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Discovery of CD3⁺CD19⁺ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry

Discovery of CD3⁺CD19⁺ cells, a novel lymphocyte subset with a potential role in human immunodeficiency virus‐Mycobacterium tuberculosis coinfection, using mass cytometry