CD20-Negative CD138-Positive Leukemic Large Cell Lymphoma with Plasmablastic Differentiation with an IgH/MYC Translocation in an HIV-Positive Patient

Yotsumoto, Mihoko; Ichikawa, Naoaki; Ueno, Makoto; Higuchi, Yumiko; Asano, Naoki; Kobayashi, Hikaru

doi:10.2169/internalmedicine.48.1359

Cited by 14 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, these results indicate that IG genes were the partner of MYC rearrangements in at least 17 of the 20 (85%) PBL. These findings are consistent with previous observations of MYC rearrangements in single case reports of PBL13, 15, 42 or small series 7, 36 . IG/MYC rearrangements were detected in the 9 cases in which both loci were examined.…”

Section: Discussionsupporting

confidence: 93%

“…IG/MYC rearrangements were detected in the 9 cases in which both loci were examined. Conventional cytogenetic studies in PBL are very limited but the previous 7 cases published and our new reported case have been concordant with the FISH observations and show that the MYC translocations occur in the context of very complex karytotypes 7, 13, 36, 42…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

IG/MYC Rearrangements are the Main Cytogenetic Alteration in Plasmablastic Lymphomas

Valera

Balagué

Colomo

et al. 2010

American Journal of Surgical Pathology

240

235

View full text Add to dashboard Cite

Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in immunocompromised or elderly patients. Although the clinical and pathological characteristics of these tumours have been defined the genetic alterations involved in their pathogenesis are not well known. In this study we have investigated the chromosomal alterations of MYC, BCL2, BCL6, MALT1, PAX5, and IGH loci using fluorescence in situ hybridization (FISH) in 42 plasmablastic lymphomas (PBL) and 3 extracavitary primary effusion lymphomas (PEL). MYC rearrangements were identified in 20 of 41 (49%) PBL and the immunoglobulin (IG) genes were the partners in most tumours. MYC rearrangements were more common in EBV-positive (14 of 19, 74%) than EBV-negative (9 of 21, 43%) tumours (p < 0.05). No rearrangements of BCL2, BCL6, MALT1 or PAX5 were detected in any PBL but gains of these loci were observed in 31-41% of the cases examined. Twelve of the 40 PBL in which 3 or more loci could be investigated had multiple simultaneous gains in 3 or more loci. No differences in the survival of the patients according to MYC were observed but the four patients with the longest survival (>50 months) had no or low number of gains (<3). No rearrangements of any of these loci were seen in PEL. In conclusion, PBL are genetically characterized by frequent IG/MYC translocations and gains in multiple chromosomal loci. The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

IG/MYC Rearrangements are the Main Cytogenetic Alteration in Plasmablastic Lymphomas

Valera

Balagué

Colomo

et al. 2010

American Journal of Surgical Pathology

240

235

View full text Add to dashboard Cite

show abstract

“…Neither the patient HIV status nor the EBV positivity of the tumour helps to differentiate these neoplasms. Clinico-pathologic features of MM can be obscured in HIV/AIDS patients [34][35][36] and cases described as PBL in the literature had clinical characteristics of MM such as monoclonal serum immunoglobulin 3 and radiographically evident disseminated bone involvement 9,35,37,38 . It is therefore clear that clinical features also do not serve as distinguishing features between these neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Dominant genetic aberrations and coexistent EBV infection in HIV-related oral plasmablastic lymphomas

et al. 2011

View full text Add to dashboard Cite

SUMMARYWe present common cytogenetic features in the largest cohort of plasmablastic lymphoma (PBL) of the oral cavity published to date. This cohort included 45 patients, 32 of whom had a known HIV status, of which thirty one were HIV positive. Ninety eight per cent of all PBL cases were known to be EBV positive. In line with previous studies, we found that rearrangements of the MYC gene was the most common genetic abnormality seen in 60% of cases with the immunoglobulin heavy chain (IGH) locus as a partner in 51% of cases. Additional complex genetic aberrations were frequent, in particular, an increased copy number of the CCND1 gene was seen in 41% of cases with true amplification of CCND1 in 15% of cases. Aneuploidy was also observed for the BCL6 gene in 28% of cases. Interestingly, rearrangements of both IGH genes were detected in 16% of cases with t(14;18) and t(11;14) respectively involved in conjunction with a t(8;14) in two cases. These bi-allelic IGH rearrangements have not been described before in oral PBL. Our results reinforce the notion that EBV infection and MYC rearrangements are important events in the pathogenesis of oral PBL. The genetic diversity and complexity observed in these cases, underlines the importance to genetically characterise PBL patients at presentation as this may inform the choice of more effective treatment modalities.3

show abstract

“…Christensen (Fig 6g–i)—that had the typical phenotypic profile (CD20 − , PAX5 − , BCL6 −/+ , IRF4/MUM1 + , CD138 + , and EBER + )—was diagnosed in the lacrimal gland and characterized by mesenteric and retroperitoneal lymphadenopathy, ascites, and bone marrow (BM) infiltration and carried the t(8;14) with MYC rearrangement. Involvement of lymph nodes is a rare event in this setting, but even rarer is the occurrence of t(8;14), so far recorded in only two cases in the literature [79, 80]. The other plasmablastic lymphoma revealed an aberrant phenotype.…”

Section: Ebv-positive Lymphomas Lymphomas Occurring In Hiv+ Individumentioning

confidence: 99%

Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

Quintanilla-Martı́nez

Jong

Mascarel

et al. 2009

J Hematopathol

View full text Add to dashboard Cite

The term “gray-zone” lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein–Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to review controversial issues in gray-zone lymphomas, a joint Workshop of the European Association for Hematopathology and the Society for Hematopathology was held in Bordeaux, France, in September 2008. The panel members reviewed and discussed 145 submitted cases and reached consensus diagnoses. This Workshop summary is focused on the most controversial aspects of gray-zone lymphomas and describes the panel’s proposals regarding diagnostic criteria, terminology, and new prognostic and diagnostic parameters.

show abstract

CD20-Negative CD138-Positive Leukemic Large Cell Lymphoma with Plasmablastic Differentiation with an IgH/MYC Translocation in an HIV-Positive Patient

Abstract: Abstract

Cited by 14 publications

References 13 publications

IG/MYC Rearrangements are the Main Cytogenetic Alteration in Plasmablastic Lymphomas

IG/MYC Rearrangements are the Main Cytogenetic Alteration in Plasmablastic Lymphomas

Dominant genetic aberrations and coexistent EBV infection in HIV-related oral plasmablastic lymphomas

Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

Contact Info

Product

Resources

About