CD2 is expressed by a subpopulation of normal B cells and is frequently present in mature B‐cell neoplasms

Kingma, Douglas W.; Imus, Paula D.; Xie, Xiu Yan; Jasper, Gregory A.; Sorbara, Lynn; Stewart, Carleton C.; Stetler‐Stevenson, Maryalice

doi:10.1002/cyto.10131

Cited by 29 publications

(21 citation statements)

References 22 publications

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“…1 Expression of T-cell antigens other than CD5 and CD43 in B-cell non-Hodgkin's lymphomas is exceptional. 20,25,26 The diffuse blastoid B-cell lymphomas in our study were almost always CD43 positive (seven of eight cases); four of these cases also expressed one or two additional T-cell-associated markers: CD5 (case 4), CD8 (case 5), CD57 (case 1), and both CD7 and CD57 (case 6). This T-cell-antigen reactivity seems to represent aberrant expression, as all six cases with successful DNA amplification showed clonal rearrangement of the immunoglobulin heavy chain gene, but not of the TCR-g chain gene.…”

Section: Diffuse Blastoid B-cell Lymphomamentioning

confidence: 51%

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

et al. 2009

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Among the diffuse lymphomas of B-cell origin, we have encountered one variant displaying blastoid features that morphologically mimic lymphoblastic lymphoma, the blastoid variant of mantle cell lymphoma, and the so-called blastoid transformation of follicular lymphoma. To better characterize this entity, we studied eight cases morphologically, immunohistochemically, and by fluorescence in situ hybridization (FISH) for cytogenetic abnormalities commonly associated with follicular lymphoma and B-cell lymphomas exhibiting high-grade histological features. All eight cases were presented as de novo neoplasms, and displayed an entirely diffuse (five cases) or only minimal follicular (three cases) growth pattern. The neoplastic lymphoid cells were of medium size with round nuclei, fine chromatin, inconspicuous nucleoli, and high mitotic rate; they expressed CD10, BCL6, and BCL2-a phenotype consistent with follicle center cell origin. A proportion of cases expressed MUM1. Their lack of TdT and CYCLIN D1 distinguished them from lymphoblastic lymphoma and the blastoid mantle cell lymphoma, respectively. The neoplastic lymphoid cells consistently expressed CD43 (seven of eight cases) and occasionally other T-cell-associated antigens, including CD5, CD7, CD8, and CD57. Although all cases overexpressed BCL2, t(14;18) was not detected in any of the five cases examined by FISH; instead, extra copies of chromosome 18 were found in four of five cases. Finally, other cytogenetic abnormalities, including structural abnormalities of BCL6 (allelic loss/gain, rearrangement), monosomy 7, del(13)(q14), and MYC allelic loss, were frequently detected. The combination of a B-cell CD10 þ BCL6 þ BCL2 þ phenotype in the presence of structural abnormalities of BCL6 is consistent with a follicular center cell derivation for our cases. The lack of t(14;18) seen in our cases, although rare in most cases of follicular lymphoma, has been nevertheless reported in cases of follicular lymphoma with a predominantly diffuse growth pattern. The molecular pathogenesis, clinical manifestations, and prognostic significance of these lesions remain to be elucidated.

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Section: Diffuse Blastoid B-cell Lymphomamentioning

confidence: 51%

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

et al. 2009

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“…Regarding CD2 expression, earlier studies found that a small proportion of mature B cells do express CD2 [25,26] and that this molecule is expressed on a substantial percentage of thymic B cells (46% in the fetal thymus and 75% in the postnatal thymus). It can also be expressed by mature circulating peripheral blood B cells (CD19+ and CD20+) in normal donors [26].…”

Section: Discussionmentioning

confidence: 99%

“…It can also be expressed by mature circulating peripheral blood B cells (CD19+ and CD20+) in normal donors [26]. The presence of CD2 on the cell surface is required to mediate cell adhesion and to facilitate antigen recognition in the absence of intracellular signaling.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and Clinical Significance of Aberrant T-Cell Marker Expression on Diffuse Large B-Cell Lymphoma Cells

Suzuki¹,

Yoshida²,

Wang³

et al. 2013

Acta Haematol

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Introduction: Aberrant expression of T-cell markers is occasionally observed in B-cell lymphomas. We conducted a retrospective study to establish its incidence and to determine its relationship with clinical features of patients with diffuse large B-cell lymphoma (DLBCL). Patients and Methods: We reviewed DLBCL patients diagnosed between January 2002 and April 2009. Patients fulfilled the following criteria: (1) age >18 years, (2) HIV negative, (3) B-cell lymphoma confirmed by restricted expression of surface immunoglobulin light chains by flow cytometry (FCM). Aberrant T-cell marker expression (ATCME) was defined as positivity for CD2, CD3, CD4, CD7, and/or CD8 on DLBCL cells by FCM. Phenotyping was also performed by immunohistochemistry (IHC). Patients were grouped according to positive or negative ATCME and their clinical features including survival were compared. Results: Of 150 patients, 11 (7.3%) showed ATCME; CD2 and CD7 were most often expressed. ATCME was less often detected and the signal was weaker using IHC. There were no statistically significant differences in clinical features between the two groups. Conclusions: FCM may be useful to detect ATCME in a small amount of lymphoma cells. The mechanism responsible for ATCME, and whether it contributes in any way to the pathogenesis of B-cell neoplastic transformation, requires clarification.

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“…It is primarily expressed on NK cells and T cells, and in humans it is also found on a subset of monocyte-derived dendritic cells, thymic B cells, and some B cell neoplasms (Bierer et al 1989;Punnonen and de Vries 1993;Crawford et al 1999;Kingma et al 2002). In mice, CD2 is found on the majority of B cells (Yagita et al 1989).…”

Section: Cd2mentioning

confidence: 99%

The CD2 Family of Natural Killer Cell Receptors

McNerney

Kumar

2006

Current Topics in Microbiology and Immunology

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CD2 is expressed by a subpopulation of normal B cells and is frequently present in mature B‐cell neoplasms

Cited by 29 publications

References 22 publications

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma

Incidence and Clinical Significance of Aberrant T-Cell Marker Expression on Diffuse Large B-Cell Lymphoma Cells

The CD2 Family of Natural Killer Cell Receptors

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