CD1d-dependent endogenous and exogenous lipid antigen presentation

McEwen-Smith, Rosanna M.; Salio, Mariolina; Cerundolo, Vincenzo

doi:10.1016/j.coi.2015.03.004

Cited by 30 publications

(43 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Certainly, APCs need to be able to capture and internalize Ag in various forms--and by various routes (1-5). This could be by phagocytosis, pinocytosis, infection by a pathogen, or even taken from within a cell as an endogenous protein or lipid.…”

Section: Introduction Of Cell Signaling Pathwaysmentioning

confidence: 99%

“…APCs mainly utilize three pathways of Ag presentation; Ags are presented by MHC or MHC-like molecules (1-5). The first pathway involves MHC class I molecules (2, 6-18).…”

Section: Introduction Of Cell Signaling Pathwaysmentioning

confidence: 99%

“…CD1 molecules are MHC class I-like molecules that generally present lipid Ags to invariant, relatively oligoclonal or even diverse T cells. These lipids can be of microbial origin or from mammalian cells themselves (5, 32). The CD1 family of Ag presenting molecules consists of two members (based on the human CD1 molecules): Group 1 includes CD1a, CD1b and CD1c molecules, whereas Group 2 consists of CD1d as its sole member (33).…”

Section: Introduction Of Cell Signaling Pathwaysmentioning

confidence: 99%

See 2 more Smart Citations

Cell Signaling Pathways That Regulate Antigen Presentation

Brutkiewicz

2016

The Journal of Immunology

View full text Add to dashboard Cite

Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis. These signaling pathways are important for various aspects of the immune response as well. However, not much is known in terms of the participation of cell signaling pathways in Ag presentation--a necessary first step in the activation of innate and adaptive T cells. In this brief review, I will discuss the known signaling molecules (and pathways) that regulate how Ags are presented to T cells and the mechanism(s) if identified. Studies in this area have important implications in vaccine development and new treatment paradigms against infectious diseases, autoimmunity and cancer.

show abstract

Section: Introduction Of Cell Signaling Pathwaysmentioning

confidence: 99%

“…APCs mainly utilize three pathways of Ag presentation; Ags are presented by MHC or MHC-like molecules (1-5). The first pathway involves MHC class I molecules (2, 6-18).…”

Section: Introduction Of Cell Signaling Pathwaysmentioning

confidence: 99%

Section: Introduction Of Cell Signaling Pathwaysmentioning

confidence: 99%

See 1 more Smart Citation

Cell Signaling Pathways That Regulate Antigen Presentation

Brutkiewicz

2016

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…CD1d is also expressed on professional APCs including dendritic cells (DCs), macrophages (Mϕ), monocytes, and some B cells. CD1d molecules present lipidic antigens to a specialized type of T lymphocyte called NKT cells [3,4]. NKT cells have the ability to secrete a wide range of cytokines including INF-γ, IL-4, IL-13, and IL-17, and they have been described to have regulatory properties in different immune responses [5].…”

Section: Introductionmentioning

confidence: 99%

Human Invariant Natural Killer T Cells Respond to Antigen-Presenting Cells Exposed to Lipids from Olea europaea Pollen

Gracia

López-Relaño²,

Revilla³

et al. 2017

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Allergic sensitization might be influenced by the lipids present in allergens, which can be recognized by natural killer T (NKT) cells on antigen-presenting cells (APCs). The aim of this study wasto analyze the effect of olive pollen lipids in human APCs, including monocytes as well as monocyte-derived macrophages (Mϕ) and dendritic cells (DCs). Methods: Lipids were extracted from olive (Olea europaea) pollen grains. Invariant (i)NKT cells, monocytes, Mϕ, and DCs were obtained from buffy coats of healthy blood donors, and their cell phenotype was determined by flow cytometry. iNKT cytotoxicity was measured using a lactate dehydrogenase assay. Gene expression of CD1A and CD1D was performed by RT-PCR, and the production of IL-6, IL-10, IL-12, and TNF-α cytokines by monocytes, Mϕ, and DCs was measured by ELISA. Results: Our results showed that monocytes and monocyte-derived Mϕ treated with olive pollen lipids strongly activate iNKT cells. We observed several phenotypic modifications in the APCs upon exposure to pollen-derived lipids. Both Mϕ and monocytes treated with olive pollen lipids showed an increase in CD1D gene expression, whereas upregulation of cell surface CD1d protein occurred only in Mϕ. Furthermore, DCs differentiated in the presence of human serum enhance their surface CD1d expression when exposed to olive pollen lipids. Finally, olive pollen lipids were able to stimulate the production of IL-6 but downregulated the production of lipopolysaccharide- induced IL-10 by Mϕ. Conclusions: Olive pollen lipids alter the phenotype of monocytes, Mϕ, and DCs, resulting in the activation of NKT cells, which have the potential to influence allergic immune responses.

show abstract

“…The nature of these autologous lipids (or self-antigens) involved in NKT cell positive selection or in the peripheral activation of NKT cells remains unclear21. Several cellular glycosphingolipids, endogenous α-glycosylceramides, lysophosphatidylcholine (LPC), lysoplasmalogens and phosphatidylinositol membrane lipid anchors have been proposed as possible major self-ligands for selecting NKT cells in the thymus and/or activating them in the periphery222324.…”

mentioning

confidence: 99%

ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content

Nowyhed

Chandra

Kiosses

et al. 2017

Sci Rep

View full text Add to dashboard Cite

ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that recognize glycolipid antigens in the context of CD1d-mediated antigen presentation. In this study, we demonstrate that ABCA7 regulates the development of NKT cells in a cell-extrinsic manner. We found that in Abca7−/− mice there is reduced expression of CD1d accompanied by an alteration in lipid raft content on the plasma membrane of thymocytes and antigen presenting cells. Together, these alterations caused by absence of ABCA7 negatively affect NKT cell development and function.

show abstract

CD1d-dependent endogenous and exogenous lipid antigen presentation

Cited by 30 publications

References 80 publications

Cell Signaling Pathways That Regulate Antigen Presentation

Cell Signaling Pathways That Regulate Antigen Presentation

Human Invariant Natural Killer T Cells Respond to Antigen-Presenting Cells Exposed to Lipids from Olea europaea Pollen

ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content

Contact Info

Product

Resources

About