CD177⁺ neutrophils as functionally activated neutrophils negatively regulate IBD

Abstract

CD177 neutrophils represent functionally activated population and play a protective role in IBD through increased bactericidal activity and IL-22 production. Targeting CD177 neutrophils may be beneficial for treatment of IBD.

Characterization and comparison of neutrophil extracellular traps in gingival samples of periodontitis and gingivitis: A pilot study

“…CD177 is expressed in neutrophils specifically and is upregulated during inflammation. CD177 + neutrophils represent functionally activated population and CD177 signals in a β2 integrin‐dependent manner to orchestrate a set of activation‐mediated mechanisms that impair human neutrophil migration . Previous studies have used CD177 as a specific neutrophil marker for the characterization of NETs, including studies on supragingival biofilms …”

Neutrophil heterogeneity: Bona fide subsets or polarization states?

“…Due to its association with PR3, a known autoantigen in systemic vasculitis, CD177 has been linked to susceptibility to autoimmunity. In addition, CD177 + neutrophils have also been noted to increase in the gut of IBD patients and are proposed to play a protective role in maintaining gut permeability through release of IL‐22 . This is supported by experimental work where CD177 deficient animals display aggravated pathology in response to experimental colitis .…”

“…In addition, CD177 + neutrophils have also been noted to increase in the gut of IBD patients and are proposed to play a protective role in maintaining gut permeability through release of IL‐22 . This is supported by experimental work where CD177 deficient animals display aggravated pathology in response to experimental colitis . While there is interperson and intraperson variability of CD177 on neutrophils, an actual role for these different subsets has not been established.…”

Neutrophil Diversity in Health and Disease

“…Indeed, whether OLFM4 + neutrophils represent a real distinct functional population remains unclear because OLFM4 + and OLFM4 − neutrophils do not display major functional differences other than a differential ability to produce NETs in vitro [22]. Notably, the frequency of OLFM4 + neutrophils is increased in sepsis relative to healthy conditions [23], whereas the frequency of circulating CD177 + neutrophils is increased in other inflammatory diseases including asthma [24], sepsis [25,26], cancer [27], and inflammatory bowel disease [28]. It is important to note that, although the presence of these subpopulations has been reported in several studies, a deeper understanding of the specific functions of these cells will be necessary to determine their prognostic or therapeutic clinical value.…”