CD163 and its role in inflammation

Kowal, Krzysztof; Silver, Richard F.; Sławińska, Emila; Bielecki, M; Chyczewski, L; Kowal-Bielecka, Otylia

doi:10.5603/fhc.2011.0052

Cited by 119 publications

(92 citation statements)

References 66 publications

(164 reference statements)

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“…As for CD163, in addition to its potential diagnostic uses in atherosclerosis-related diseases, it is also an interesting candidate for medical therapy (19,57,58,60). This is because CD163, as an example of the atheroprotective intraplaque population, eliminates free-Hb and releases a large quantity of anti-inflammatory mediators via activating downstream pathways (62,64). Additionally, CD163 has the potential to diminish inflammation in atherosclerosis by recognizing and internalizing TWEAK.…”

Section: Therapeutic Considerationsmentioning

confidence: 99%

“…CD163 is a type I transmembrane protein that belongs to group B of the scavenger receptor cysteine-rich (SRCR) superfamily (61). According to the number of cysteine residues in each SRCR domain, receptors in the SRCR superfamily are divided into groups A and B (62). CD163 consists of nine consecutive SRCR class B domains in the extracellular domain and its transmembrane moiety spans the plasma membrane once (61).…”

Section: Cd163: the Second Definite Receptormentioning

confidence: 99%

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The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors

Liu

Lin

Xiang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. At present, it is commonly accepted that atherosclerosis is a chronic inflammatory disease characterized by disorder of the arterial wall. As one of the inflammatory cytokines of the tumor necrosis factor superfamily, tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in the formation and progression of atherosclerosis. TWEAK, when binding to its initial receptor, fibroblast growth factor inducible molecule 14 (Fn14), exerts adverse biological functions in atherosclerosis, including dysfunction of endothelial cells, phenotypic change of smooth muscle cells and inflammatory responses of monocytes/macrophages. However, accumulating data supports that, besides Fn14, TWEAK also binds to cluster of differentiation (CD)163, an anti-inflammatory cytokine and a scavenger receptor exclusively expressed by monocytes and macrophages. Furthermore, it has been demonstrated that CD163 is able to internalize TWEAK and likely elicits protective effects in atherosclerosis by terminating inflammation induced by TWEAK. In the present study, the role of TWEAK in atherosclerosis was reviewed, with a predominant focus on CD163 and Fn14 receptors.

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Section: Therapeutic Considerationsmentioning

confidence: 99%

Section: Cd163: the Second Definite Receptormentioning

confidence: 99%

The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors

Liu

Lin

Xiang

et al. 2017

Experimental and Therapeutic Medicine

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“…CD163-expressing macrophages can take up haptoglobin-hemoglobin complexes, leading to the increased secretion of IL-10 and the expression of hemeoxygenase -1 (12).…”

Section: Introductionmentioning

confidence: 99%

Serum Soluble CD163 and its association with various disease parameters in patients with systemic sclerosis

et al. 2016

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Objective: Cluster of differentiation 163 (CD163) is a receptor that binds haptoglobin-hemoglobin complexes and is mainly expressed on macrophages and monocytes. As a result of shedding, the extracellular portion of CD163 circulates in the blood as a soluble CD163 (sCD163). This study aimed to measure serum sCD163 levels in patients with systemic sclerosis (SSc) and to assess its association with the clinical, laboratory, and radiological features of the disease. Material and Methods:We measured serum sCD163 levels in 24 patients with SSc and in 30 healthy controls. Complete history of the patients was recorded and thorough clinical, rheumatological, and dermatological examinations were performed. For SSc, the skin thickness score was scored according to the modified Rodnan skin score method and pulmonary involvement was assessed in all patients using high-resolution computed tomography and by performing pulmonary function tests. Results:The mean serum sCD163 levels in patients with diffuse and limited SSc (61.64±19.57 and 60.8±21.43 ng/mL, respectively) demonstrated a highly statistically significant increase compared with the mean serum levels in healthy controls (36.97±16.37 ng/ mL) (p<0.001). Patients with SSc having elevated serum sCD163 levels had significantly higher pulmonary artery systolic pressure (PASP) than those with normal serum sCD163 levels (p<0.05). Furthermore, the serum sCD163 levels were significantly correlated with PASP (r=0.53, p<0.05) in patients with SSc. The mean serum sCD163 level in patients with SSc having digital ulceration (DU) (70.82±18.3 ng/mL) demonstrated a statistically significant increase (p<0.05) compared with that in SSC patients without DU (53.23±18.09 ng/mL). Conclusion:The elevated serum sCD163 levels in patients with SSc and its association with pulmonary hypertension suggest a possible role of macrophages in the pathogenesis and vascular involvement of SSc.

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“…What is surprising is the lack of a direct relationship between CD163 and IL-4R, receptor for other mediators of alternative macrophage activation, although such correlation exists between IL-4R and CD206. A possible explanation for this variation can be derived from previous work demonstrating that IL-4, in contrast to upregulating effects of IL-10, can strongly downregulate monocyte CD163 expression [14]. Interestingly, IL-4R, a molecule involved in pro-allergic actions despite being expressed at low levels by monocytes, is strongly correlated to IL-10R, which is widely attributed to anti-allergic actions.…”

Section: Discussionmentioning

confidence: 99%

“…The data demonstrating an upregulation of CD206 and IL-10R and a downregulation of IL-4R expression on monocytes, together with an enrichment of CD16-positive monocyte subsets in allergic patients, call for further studies exploring in detail the role of monocytes and other cells of the innate immune system in the regulation of allergic inflammation [14]. …”

Section: Discussionmentioning

confidence: 99%

Phenotypic Correlations between Monocytes and CD4+ T Cells in Allergic Patients

Moniuszko

Kowal²,

Jeznach³

et al. 2013

Int Arch Allergy Immunol

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Despite widely acknowledged contributions of innate and adaptive immune systems to the pathogenesis of allergic diseases, mutual interactions occurring in vivo between components of those two systems have not been studied in sufficient detail. Here, we wished to investigate whether phenotypic features of monocytes and CD4+ T cells in allergic patients are reciprocally related. Therefore, we recruited 50 untreated house dust mite-sensitive allergic rhinitis patients and 29 non-atopic healthy individuals and performed comprehensive simultaneous flow cytometric analysis of mutual correlations between levels of CD14, CD16, CD163, CD206, CD124 (IL-4R), CD210 (IL-10R) and CD25, CD124, CD127 (IL-7R), CD210, ICOS expression on monocytes and CD4+ T cells, respectively. We found that CD163 monocyte expression in allergic but not healthy subjects is positively correlated with monocyte IL-10R, and, to a lesser extent, CD206, but not IL-4R expression. Levels of CD163 expression were not related to frequencies of CD14++CD16–, CD14++CD16+, and CD14+CD16++ monocyte subsets. In contrast to healthy controls, intensities of monocyte IL-10R in allergic individuals were significantly correlated with monocyte CD206 and IL-4R expression. In addition, levels of monocyte IL-4R and IL-10R monocyte expression were positively correlated to expression of IL-4R and IL-10R on CD4+ T cells in both groups of studied subjects. Interestingly, we demonstrated a significant positive correlation between levels of monocyte CD206 expression and levels of IL-10R and IL-4R expression on CD4+ T cells in allergic but not healthy individuals. In summary, we conclude that allergic rhinitis is associated with a number of phenotypic alterations of circulating monocytes and CD4+ T cells.

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CD163 and its role in inflammation

Cited by 119 publications

References 66 publications

The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors

The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors

Serum Soluble CD163 and its association with various disease parameters in patients with systemic sclerosis

Phenotypic Correlations between Monocytes and CD4+ T Cells in Allergic Patients

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