CD16<sup>high</sup>CD62L<sup>dim</sup> neutrophils induce nerve‐mediated airway hyperreactivity

Ekstedt, Sandra; Larsson, Olivia; Georén, Susanna Kumlien; Cardell, Lars Olaf

doi:10.1111/cea.13602

Cited by 6 publications

(7 citation statements)

References 15 publications

(16 reference statements)

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“…To get further understanding of the phenotype of neutrophils, we measured the expression of CD62L, which is down regulated during neutrophil activation 34, 35 . Neutrophils from PLHIV had lower expression of CD62L than those from HIV-uninfected participants (Median fluorescent intensity (MFI) 310 [95% CI 264-356] vs. 399 [95% CI 345-453], p=0.017) (Fig 5e).…”

Section: Resultsmentioning

confidence: 99%

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Frequent shedding of multi-drug resistant pneumococci among adults living with HIV on suppressive antiretroviral therapy in Malawi

Sibale

Phiri

Mitole

et al. 2022

Preprint

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People living with human immunodeficiency virus (PLHIV) on antiretroviral therapy (ART) are reported to have three times higher carriage ofStreptococcus pneumoniaethan their HIV-uninfected counterparts in point prevalence studies. Using a longitudinal cohort study design, we assessed pneumococcal carriage density, shedding and antibiotic resistance profiles, as well as nasal mucosal immunity, in otherwise healthy PLHIV on ART for at least one year, compared to HIV-uninfected participants in Malawi. Pneumococcal carriage density was higher among PLHIV compared to HIV-uninfected participants. Moreover, PLHIV were twice more likely to shed pneumococci than HIV-uninfected participants. In PLHIV, aerosol shed pneumococci were more often multi-drug resistant (MDR) than nasopharyngeal carried isolates recovered from the same individual. Consistent with high shedding, PLHIV exhibited heightened neutrophil-mediated nasal mucosa inflammation. We propose that PLHIV should be considered in intervention strategies, such as vaccination, as they could be an important reservoir for transmission of MDRS. pneumoniae.

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Section: Resultsmentioning

confidence: 99%

“…To get further understanding of the phenotype of neutrophils, we measured the expression of CD62L, which is down regulated during neutrophil activation 34,35 .…”

Section: Higher Density Pneumococcal Carriage In Plhiv Than Hiv-uninf...mentioning

confidence: 99%

Frequent shedding of multi-drug resistant pneumococci among adults living with HIV on suppressive antiretroviral therapy in Malawi

Sibale

Phiri

Mitole

et al. 2022

Preprint

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“…The surface markers of memory T cells in mice differ from those in humans, and the expression level of CD44 in mice is used to define memory T cells—cells with low expression of CD44 are defined as naive T cells and cells with high expression of CD44 are defined as memory T cells. CD62L is then used to distinguish central and effector memory T cells—cells with CD62L + are defined as central‐type and cells with CD62L − are defined as effector‐type 18 . Since IL − 23 mainly acts on effector memory T cells, 19 the surface marker of CD44highCD62L − was selected to detect the number of memory T cells in this study.…”

Section: Discussionmentioning

confidence: 99%

“…CD62L is then used to distinguish central and effector memory T cells—cells with CD62L + are defined as central‐type and cells with CD62L − are defined as effector‐type. 18 Since IL − 23 mainly acts on effector memory T cells, 19 the surface marker of CD44highCD62L − was selected to detect the number of memory T cells in this study. According to the findings of this study, the proportion of memory T cells (CD4 + Tm) mice in the sensitized group was considerably higher than in the control and nonsensitized groups.…”

Section: Discussionmentioning

confidence: 99%

The role of memory T cells in Echinococcus granulosus‐induced sensitization

Zhou,

Du,

Abulajiang

et al. 2023

Immunity Inflam & Disease

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ObjectiveTo investigate the changes in memory T cells and the related factors in mice by the establishment of a BALB/c mouse model of Echinococcus granulosus‐induced sensitization.MethodsA sensitized BALB/c mouse model was established by intraperitoneal injection of E. granulosus. A control group (CTRL), a nonsensitized group infected with E. granulosus (CE), and a sensitized group infected with E. granulosus (ANPC) were set up. The pathological changes in lung tissue in mice, the change in memory T cells (CD4 Tm), and the change in peripheral blood nucleated interleukin‐23 (IL‐23) were detected using HE staining, flow cytometry, and liquid‐phase multiple protein quantification techniques, respectively.ResultsThe individual percentage of mouse memory T cells was 9.14 ± 0.45, 25.23 ± 0.17, and 13.29 ± 0.32 in the CTRL, CE, and ANPC groups, respectively. The percentage of memory T cells in the ANPC group was higher than that in the CTRL group (t = 18.410, p < .001) but lower than that in the CE group (t = −80.147, p < .001). The levels of IL‐23 in peripheral blood of mice in the CTRL, CE, and ANPC groups were 225.76 ± 27.16, 359.21 ± 28.67, and 215.69 ± 22.69, respectively. The level of IL‐23 in peripheral blood of mice in the ANPC group was lower than that in the CE group (t = 9.609, p < .001), and there was no statistical difference with the CTRL group (t = 0.697, p = .502).ConclusionIn the BALB/c mouse model of E. granulosus‐induced sensitization, the expression of IL‐23 in peripheral blood increased, and the memory T cell proliferated and became activated; there was a decrease in the content of IL‐23 in peripheral blood and number of activated memory T cells in the sensitization group infected with E. granulosus. The E. granulosus‐induced allergic reaction was related to IL‐23 and the activation of memory T cells.

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“…We have finally entered the much‐anticipated era of personalized medicine for asthma, and several articles evaluated biologics and the variation in individual response to these in people with asthma 25‐27 , 28‐36 , 37 , 38 Others evaluated more traditional treatments for asthma, such as corticosteroids or mechanisms that may underlie impaired airway function in asthma 39‐59 . New interventions studied in clinical trials included air cleaners, triple inhaler therapy, an oral prostaglandin D2 antagonist 60‐62 and other more preliminary data from various interventions, from cinnamon and bacterial peptides to allergen immunotherapy 63‐67 .…”

Section: Asthmamentioning

confidence: 99%

Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy

Boyle

Shamji

2021

Clin Experimental Allergy

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CD16^highCD62L^dim neutrophils induce nerve‐mediated airway hyperreactivity

Cited by 6 publications

References 15 publications

Frequent shedding of multi-drug resistant pneumococci among adults living with HIV on suppressive antiretroviral therapy in Malawi

Frequent shedding of multi-drug resistant pneumococci among adults living with HIV on suppressive antiretroviral therapy in Malawi

The role of memory T cells in Echinococcus granulosus‐induced sensitization

Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy

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CD16highCD62Ldim neutrophils induce nerve‐mediated airway hyperreactivity

Cited by 6 publications

References 15 publications

Frequent shedding of multi-drug resistant pneumococci among adults living with HIV on suppressive antiretroviral therapy in Malawi

Frequent shedding of multi-drug resistant pneumococci among adults living with HIV on suppressive antiretroviral therapy in Malawi

The role of memory T cells in Echinococcus granulosus‐induced sensitization

Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy

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CD16^highCD62L^dim neutrophils induce nerve‐mediated airway hyperreactivity