2022
DOI: 10.1093/cei/uxac020
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CD155 expression impairs anti-PD1 therapy response in non-small cell lung cancer

Abstract: CD155 is an immune checkpoint protein expressed in tumor cells that interacts with its ligand TIGIT, and inhibition of this point presents a new and novel way for cancer therapy. At present, whether the expression of CD155 affects the response to anti(α)-PD1 treatment in non-small cell lung cancer (NSCLC) patients is unclear. This observational study characterizes the expression of CD155 in NSCLC patients and its responses to PD1 inhibitors. We retrospectively detected the expression of CD155 and tumor-infiltr… Show more

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Cited by 8 publications
(4 citation statements)
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“…Studies were published between 2018 and 2022. Zhao JJ ( 27 ), Peipei Wang ( 28 ) and Zhao K ( 29 ) reported survival outcomes of esophageal squamous cell carcinoma (ESCC) or primary small cell carcinoma of esophagus (PSCCE), Tang W ( 30 ) and Liu HF ( 31 ) reported gastric cancer (GC), Xu Y ( 32 ) reported small cell lung cancer (SCLC), Sun Y ( 33 ) and Jiang C ( 34 ) reported non-small cell lung cancer (NSCLC), Zhou X ( 35 ), Liang R ( 36 ) and Daisuke Murakami ( 37 ) reported colorectal cancer (CRC), Lee WJ ( 38 ) reported melanoma, Yu LH ( 39 ) reported hepatitis B virus hepatocellular carcinoma (HBV-HCC), and Liu ZP et al. reported the ZSHS cohort and the FUSCC cohort that reported survival outcomes of patients with muscle-invasive bladder cancer (MIBC) ( 40 ).…”
Section: Resultsmentioning
confidence: 99%
“…Studies were published between 2018 and 2022. Zhao JJ ( 27 ), Peipei Wang ( 28 ) and Zhao K ( 29 ) reported survival outcomes of esophageal squamous cell carcinoma (ESCC) or primary small cell carcinoma of esophagus (PSCCE), Tang W ( 30 ) and Liu HF ( 31 ) reported gastric cancer (GC), Xu Y ( 32 ) reported small cell lung cancer (SCLC), Sun Y ( 33 ) and Jiang C ( 34 ) reported non-small cell lung cancer (NSCLC), Zhou X ( 35 ), Liang R ( 36 ) and Daisuke Murakami ( 37 ) reported colorectal cancer (CRC), Lee WJ ( 38 ) reported melanoma, Yu LH ( 39 ) reported hepatitis B virus hepatocellular carcinoma (HBV-HCC), and Liu ZP et al. reported the ZSHS cohort and the FUSCC cohort that reported survival outcomes of patients with muscle-invasive bladder cancer (MIBC) ( 40 ).…”
Section: Resultsmentioning
confidence: 99%
“…Some scholars classify these receptors as members of the CD155 family, and multiple intricate interactions exist among them [ 23 ]. Especially in tumour tissues, the interaction of TIGIT with CD155 has been applied to clinical tumour treatment [ 24 ]. Therefore, in this chapter, we conducted further testing of this family of molecules using flow cytometry, and the results showed that the expression of CD96 on immune cells was consistent with the results of immunofluorescence, while there was no significant difference in the expression of TIGIT between the endometrium tissue and normal pregnancy decidua.…”
Section: Discussionmentioning
confidence: 99%
“…In melanoma patients with an inflamed TME, CD155 was associated with ICI resistance, including both primary and acquired resistance [ 25 ]. Meanwhile, Jiang, C. et al discovered that the response to anti-PD-1 is correlated to CD155 expression rather than TIGIT expression [ 94 ].
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Section: Tigit: Expression Function and The Signaling Pathwaymentioning
confidence: 99%