CD154/CD40-Mediated Expression of CD154 in Endothelial Cells: Consequences for Endothelial Cell–Monocyte Interaction

Wagner, Andreas H.; Güldenzoph, Björn; Lienenlüke, Bianca; Hecker, Markus

doi:10.1161/01.atv.0000122853.99978.b1

Cited by 66 publications

(53 citation statements)

References 22 publications

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“…It has been reported that CD40 L propagates endothelial proinflammatory reactions by stimulating CD40 L synthesis [21] and by enhancing production of reactive oxygen species that act to limit endothelial migration [22]. Ligation of CD40 on vascular wall cells may promote mononuclear cell recruitment, participate in the weakening of the plaque, and set the stage for thrombotic events of crucial importance in the atherothrombotic process [21].…”

Section: Discussionmentioning

confidence: 99%

“…Ligation of CD40 on vascular wall cells may promote mononuclear cell recruitment, participate in the weakening of the plaque, and set the stage for thrombotic events of crucial importance in the atherothrombotic process [21]. Furthermore, ligation of CD40 on endothelial cells, smooth muscle cells, or mononuclear phagocytes triggers the expression of various pro-inflammatory mediators, such as the cytokines interleukin (IL)-1, IL-6, IL-12, tumor necrosis factor-␣, and interferon-␥; the chemokines IL-8, monocyte chemoattractant protein-1, and RANTES (regulated upon activation, normal T cell expressed and secreted); intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, matrix metalloproteinases as well as the procoagulant tissue factor [21].…”

Section: Discussionmentioning

confidence: 99%

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Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables

et al. 2010

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a b s t r a c tIntroduction: Accumulating evidence suggests that inflammation plays an important role in the acute phase of ischemic stroke. CD40 L is a well recognized atherosclerotic inflammatory marker, whereas recent evidence suggests a pro-inflammatory role of Fetuin-A. To analyze the role of an inflammatory marker such as CD40 L and of a candidate pro-inflammatory marker such as Fetuin-A in acute stroke we evaluated their serum levels in subjects with acute ischemic stroke and their possible association with other laboratory and clinical variables. Materials and methods:We enrolled 107 consecutive patients with a diagnosis of acute ischemic stroke admitted to the Internal Medicine Department at the University of Palermo between November 2006 and January 2008, and 102 hospitalized control patients without a diagnosis of acute ischemic stroke. Results: Patients with acute ischemic stroke in comparison to control subjects without acute ischemic stroke had significantly higher CD40 L levels and Fetuin-A serum levels. No significant differences in plasma CD40 L or Fetuin-A levels among different TOAST groups were detected. At intragroup (intra-TOAST-subtype) correlation analysis, among subjects classified as lacunar, CD40 L plasma levels were positively correlated with LDL-cholesterol and with diabetes, whereas Fetuin-A was significantly (positively) correlated with hypertension and white blood cell count. Among subjects with LAAS subtype, CD40 L levels were positively correlated with triglyceride plasma levels and Fetuin-A, whereas Fetuin-A levels were positively correlated with LDL-cholesterol. Discussion: Our findings suggest a pro-inflammatory role of Fetuin-A and CD40 L in acute stroke setting. Whether this role should be construed as direct or as a simple expression of a general inflammatory activation will be up to future studies to clarify.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables

et al. 2010

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“…23 The CD40/CD40L system represents a major costimulator system triggering different signaling pathways mainly attending as amplification of immune and inflammatory responses, 25 including in endothelial cells. 26,27 Therefore, CD40L can be implicated in promoting inflammation, 9 angiogenesis, 28 and endothelial dysfunction. 7,29 Furthermore, overexpression of CD40 and CD40L was demonstrated in hearts of mice with myocarditis providing a mechanistic link between damaged myocardium and immune response.…”

Section: Discussionmentioning

confidence: 99%

Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes

Napoleão

Cabral

Selas

et al. 2016

Translational Research

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Involvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (,2.3 ng/mL) were associated with higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), high frequency of G894T polymorphism, and altered expression of a set of microRNAs assumed to be involved in the regulation of endothelial and cardiac function and myocardium hypertrophy, relative to patients in sCD40L upper quartiles. A characteristic sCD40L variation pattern in STEMI patients was identified. Low levels of sCD40L 1 month after PCI distinguish STEMI patients with worse prognosis, a compromised cardiac healing, and a persistent endothelial dysfunction, as given by the association between sCD40L, NT-proBNP, G894T polymorphism, and specific profile of miRNA expression. These results suggest sCD40L could have a prognostic value in STEMI patients. (Translational Research 2016;176:95-104) Abbreviations: AMI ¼ acute myocardial infraction; CAD ¼ coronary artery disease; eNOS ¼ endothelial nitric oxide synthase; miR ¼ microRNA; NT-proBNP ¼ N-terminal pro-brain natriuretic peptide; PCI ¼ percutaneous coronary intervention; sCD40L ¼ soluble CD40 ligand; STEMI ¼ ST segment elevation myocardial infraction

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“…First, activation of CD40 on endothelial cells results in the expression of adhesion molecules, including vascular cell adhesion molecule (VCAM)-1, intercellular cell adhesion molecule (ICAM)-1 and E-selectin. 35 Second, macrophages present in initial plaques secrete pro-inflammatory chemokines upon CD40L exposure such as MCP-1, MIP-1α, MIP-1β and Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES). 36,37 Third, platelet CD40L contributes to the formation of platelet-leukocyte aggregates and promotes leukocyte adhesion to the activated endothelium.…”

Section: The Key Role Of Cd40-cd40l In Vascular Inflammationmentioning

confidence: 99%

CD40–CD40L: Linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications

Seijkens

Kusters

Engel

et al. 2012

Diabetes and Vascular Disease Research

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Numerous epidemiological studies have consistently demonstrated the strong association between type 2 diabetes mellitus (T2DM) and an increased risk to develop cardiovascular disease. The pathogenesis of T2DM and its complications are characterized by pancreatic, adipose tissue and vascular inflammation. CD40 and CD40L, members of the tumour necrosis factor (receptor) TNF(R) family, are well known for their role in immunity and inflammation. Here we give an overview on the role of CD40-CD40L interactions in the pathogenesis of T2DM with a special focus on pancreatic, adipose tissue and vascular inflammation. In addition, we explore the role of soluble CD40L (sCD40L) as a potential biomarker for the development of cardiovascular disease in T2DM subjects. Finally, the therapeutic potential of CD40-CD40L inhibition in T2DM is highlighted.

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CD154/CD40-Mediated Expression of CD154 in Endothelial Cells: Consequences for Endothelial Cell–Monocyte Interaction

Abstract: By way of CD154-induced CD154 expression, human endothelial cells thus seem capable of influencing the progression of proinflammatory reactions, including atherogenesis through activation of extravasating monocytes.

Cited by 66 publications

References 22 publications

Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables

Fetuin-A and CD40 L plasma levels in acute ischemic stroke: Differences in relation to TOAST subtype and correlation with clinical and laboratory variables

Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes

CD40–CD40L: Linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications

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