CD147 renal expression as a biomarker for progressive IgAN

Sun, Shan; Zhao, Ali; Li, Rong; Du, Rui; He, Lijie; Sun, Wenjuan; Wang, Hanmin; Huang, Chen

doi:10.1007/s40620-014-0161-1

Cited by 13 publications

(14 citation statements)

References 20 publications

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“…They detected a significant indirect relationship of CD147 staining of kidney tubules with proportion of glomerular filtration. They also found a significant direct relationship of CD147 staining of kidney tubular cells with serum creatinine levels and also with lesions of tubulointerstitial area (8). Interestingly, they found that elevated CD147 expression was correlated with reduced kidney survival.…”

Section: Discussionmentioning

confidence: 88%

Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis

Amiri¹,

Abedini²,

Baradaran³

2018

J Nephropathol

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Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory disorder that affects the kidney in around 50% of patients Objectives: The aim of this study was to assess CD147 expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV lupus nephritis. Patients and Methods: These patients with lupus nephritis classes II and IV by renal biopsy and pathology were enrolled in this study. The strength of CD147 staining on tubules, Bowman's capsules, vessels and tuft of glomeruli was expressed as proportion of involvement. Results: In this study, 23 renal biopsies for lupus nephritis of classes III and IV (documented by immunofluorescence and light microscopic studies) were included. No significant difference of CD147 staining between classes was detected (P > 0.05). In addition, proportion of proteinuria was not related to CD147 staining in tubules, Bowman's capsules, vessels and tuft of glomeruli in classes III and IV lupus nephritis (P > 0.05). There was no significant association of CD147 staining in tubules, Bowman's capsules and vessels with serum creatinine (P > 0.05). However, an association between CD147 staining in tuft of glomeruli with serum creatinine was detected (r=0.623, P = 0.002). None of chronicity or activity percent of glomerular involvement in two classes of III or IV had a significant association with CD147 staining (P > 0.05). Conclusions: The significant association between CD147 staining in glomeruli with serum creatinine in lupus nephritis of classes III and IV revealed that inflammation at this area may have prognostic implication.

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Section: Discussionmentioning

confidence: 88%

Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis

Amiri¹,

Abedini²,

Baradaran³

2018

J Nephropathol

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“…However, it is not well-defined whether the presentation of CD147 associates with tubulointerstitial damage in IgA nephropathy patients. In a study conducted by Sun and colleagues on 86 renal biopsies from patients with IgA nephropathy, CD147 presentation was observed in the basolateral membrane of kidney cell tubules, while in normal renal specimens, positive staining for CD147 was not expressed in the renal tubular epithelial cells (6). They found a significant indirect correlation of CD147 staining of renal tubules with glomerular filtration rate.…”

Section: Discussionmentioning

confidence: 95%

“…Finally, they concluded that CD147 presentation was accompanying with tubulointerstitial damage. Likewise they concluded that CD147 immunostaining intensity may predict kidney prognosis in IgA nephropathy, while CD147 may act as an early index for tubulointerstitial damage in IgA nephropathy (6). More recently, Mori and colleagues considered the clinical significance of CD147 in biopsy-proven renal diseases which directed to the development of chronic renal failure (7).…”

Section: Discussionmentioning

confidence: 99%

“…CD147, as a type I membrane glycoprotein has been presented by several cell types, comprising epithelial and endothelial cells. In normal renal tissue, CD147 is scattered in tubular epithelial cells and to a lesser intensity in glomerular components (6). The expression of CD147 is also significantly amplified in damaged renal proximal tubular epithelial cells.…”

Section: Introductionmentioning

confidence: 97%

“…Additionally, it may be an important regulator in fibrosis of tubulointerstitial area. In fact, kidney fibrosis might be the main factor to have a prognostic implication of chronic progressive renal insufficiency (6,7). However, the clinical significance and morphological features of CD147 presentation in IgA nephropathy patients did not completely investigate and few studies had been published on this subject.…”

Section: Introductionmentioning

confidence: 99%

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Association of CD147 renal expression with morphologic lesions of Oxford classification in IgA nephropathy patients

Amiri¹,

Mardani²,

Rad³

et al. 2018

J Renal Inj Prev

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Introduction:Nephropathy of immunoglobulin A (IgA), is the most frequent glomerulonephritis worldwide. Nephropathy of IgA, has a highly variable course, either clinically or pathologically. Objectives: The aim of this study was to assess CD147 expression with four morphological lesions of Oxford classification in IgA nephropathy patients. Patients and Methods:The characterization of IgA nephropathy necessitated the existence of diffuse and global mesangial IgA deposition with weak C1q deposition. The kidney biopsies with the diagnosis of IgA nephropathy were included in the study. After the diagnosis of IgA nephropathy, four pathologic variables, of the Oxford classification of IgA nephropathy were assessed. For immunohistochemical staining, 4-μm-thick sections were stained with anti-human CD147 antibody. The intensity of CD147 staining on tubules, Bowman's capsules, vessels and tuft of glomeruli was expressed as percentage of involvement. Results: In this study, 48 consecutive renal biopsies documented for IgA nephropathy were selected. Mean age of patients was 38.4±12.6 years. The average of proteinuria and serum creatinine were 1620.33± 720 mg/d and 1.33±0.54 mg/dL, respectively. We found vessels had the least and tubules had the highest mean of intensity of CD147 staining. This study showed that the intensity of CD147 staining in glomeruli was much higher among women than men. In addition, the association of T1 and T2 as the morphologic variables of Oxford classification with CD147 intensity staining on tubules was significant (P = 0.032). Conclusion: IgA nephropathy is common in various parts of the world. Beyond the Oxford classification, further work is still needed, to find other parameters having prognostic implication. Our study revealed some correlations of CD147; however, larger investigations are needed on this aspect of IgA nephropathy.

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Liquid biopsy in kidney tumor

Aghamir

Mashhadi

Ahadi

et al. 2022

Liquid Biopsy in Urogenital Cancers and Its Clinical Utility

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CD147 renal expression as a biomarker for progressive IgAN

Abstract: CD147 expression is associated with tubulointerstitial injury and predicts renal prognosis in IgA nephropathy. CD147 may be an early marker for tubulointerstitial injury IgA nephropathy.

Cited by 13 publications

References 20 publications

Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis

Relationship of CD147 kidney expression with various pathologic lesions, biochemical and demographic data in patients with classes III and IV of lupus nephritis

Association of CD147 renal expression with morphologic lesions of Oxford classification in IgA nephropathy patients

Liquid biopsy in kidney tumor

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