CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function

Chen, Chen; Liu, Shuang; Zeng, Weiqi; Su, Juan; Wu, Lisha; Luo, Zhu; Zhou, Shuangyuan; Li, Qingling; Zhang, Jianglin; Kuang, Yehong; Chen, Xiang

doi:10.1016/j.jdermsci.2013.02.005

Cited by 21 publications

(20 citation statements)

References 40 publications

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“…CD147 is expressed in epithelial cells [99], fibroblasts [123], psoriatic peripheral blood mononuclear cells [124], cytotrophoblasts [125], the normal basal epithelial layer reportedly harboring stem cells [126], ectopic endometrial tissues [127], systemic lupus erythematosus [128], synovial joint disease tissue of rheumatoid arthritis (RA) patients [115,129], plasma of lupus nephritis patients [130], peripheral monocytes and T lymphocytes of patients with ankylosing spondylitis [131]. …”

Section: The Expression and Role Of Cd147 In Tissues And Diseases mentioning

confidence: 99%

“…CD147 regulates ABCG2-mediated transport of the cytotoxic agent methotrexate in immune cells [124], although this mechanism remains poorly characterized. CD147 can form a complex with ABCG2 on the cell membrane in primary effusion lymphoma and breast cancer cells, as determined by co-immunoprecipitation [71,145].…”

Section: Recent Studies On the Regulatory Mechanism Of Cd147mentioning

confidence: 99%

“…Moreover, targeting CD147 may reduce VEGF secretion and EC migration in the KS microenvironment, so it is a novel and potential treatment for KSHV-associated tumors [112,113,114]. In addition, CD147 has been considered in the clinical treatment of psoriatic patients resistant to methotrexate [124], and inhibition of CD147 expression may be a potential treatment of ongoing edema after SAH [19]. Anti-CD147 may prevent the excessive entry of leukocytes into the CNS in conditions for multiple sclerosis therapy [122].…”

Section: Clinical Applications Of Cd147mentioning

confidence: 99%

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The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Xiong

Edwards

Zhou

2014

IJMS

183

194

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CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokines. CD147 regulates cell proliferation, apoptosis, and tumor cell migration, metastasis and differentiation, especially under hypoxic conditions. CD147 is also important to many organ systems. This review will provide a detailed overview of the discovery, characterization, molecular structure, diverse biological functions and regulatory mechanisms of CD147 in human physiological and pathological processes. In particular, recent studies have demonstrated the potential application of CD147 not only as a phenotypic marker of activated regulatory T cells but also as a potential diagnostic marker for early-stage disease. Moreover, CD147 is recognized as an effective therapeutic target for hepatocellular carcinoma (HCC) and other cancers, and exciting clinical progress has been made in HCC treatment using CD147-directed monoclonal antibodies.

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Section: The Expression and Role Of Cd147 In Tissues And Diseases mentioning

confidence: 99%

Section: Recent Studies On the Regulatory Mechanism Of Cd147mentioning

confidence: 99%

Section: Clinical Applications Of Cd147mentioning

confidence: 99%

See 1 more Smart Citation

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Xiong

Edwards

Zhou

2014

IJMS

183

194

View full text Add to dashboard Cite

show abstract

“…Newer insights into traditional therapies have been investigated, such as downregulation of IL-22 receptor by calcipotriol and a role of CD147 to promote resistance to methotrexate [36,37]. In addition, recent reports have revealed therapeutic targets in the development of psoriatic skin lesions (Fig.…”

Section: New Therapeutic Targets For Psoriasismentioning

confidence: 99%

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Miyagaki

Sugaya

2015

Journal of Dermatological Science

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“…The pGC-Fu-CD147 plasmid encoding CD147 cDNA and the pSUPER/CD147 short hairpin (sh)RNA vector targeting human CD147 mRNA were constructed and packaged with a lentivirus by Shanghai GeneChem Co., Ltd. (Shanghai, China) as described previously (22,26). Briefly, the cDNA containing the entire region of human CD147 was prepared by Agel enzyme digestion (Shanghai Genechem Co., Ltd.) and cloned into the pGCFU vector (Shanghai GeneChem Co., Ltd.).…”

Section: Methodsmentioning

confidence: 99%

Cluster of differentiation 147 mediates chemoresistance in breast cancer by affecting vacuolar H+-ATPase expression and activity

et al. 2018

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Abstract. Vacuolar H + -ATPase (V-ATPase) serves a key role in adjusting and maintaining the intracellular pH, as well as in regulating the drug resistance of tumor cells. In recent years, the expression level of V-ATPase has been considered to be able to predict the sensitivity of breast cancer cells to chemotherapy drugs. Cluster of differentiation 147 (CD147) is known to serve a key role in the development and progression of breast cancer. The present study aimed to identify the role CD147 and V-ATPase in chemoresistance in breast cancer, and to characterize the regulation of CD147 on V-ATPase. Firstly, the expression levels of CD147 and V-ATPase were detected in chemotherapy-resistance breast cancer samples. It was demonstrated that V-ATPase was highly expressed in chemotherapy-resistance breast cancer samples, and that its expression was correlated with CD147 expression. Subsequently, MCF-7 and MDA-MB-231 cells were used to study the regulatory effect of CD147 on the expression and function of V-ATPase. Gene transfection or small interfering RNA transfection were used to control the expression of CD147 in the two cell lines. The results revealed that the overexpression of CD147 increased the expression of V-ATPase in MCF-7 cells, whereas CD147 knockdown decreased V-ATPase expression in MDA-MB-231 cells. It was also observed that CD147 affected the V-ATPase activity, regulating the transmembrane pH gradient of cancer cells. These results demonstrated that CD147 was associated with the sensitivity of chemotherapeutic drugs of epirubicin and docetaxel, while pantoprazole was able to partially reverse the CD147-mediated chemoresistance in breast cancer. Therefore, the current study provided a possible mechanism for further examination of drug resistance in breast cancer.

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CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function

Cited by 21 publications

References 40 publications

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Cluster of differentiation 147 mediates chemoresistance in breast cancer by affecting vacuolar H+-ATPase expression and activity

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