CD14 tobacco gene–environment interaction in atopic children

Hussein, Yousri M.; Shalaby, Sally M.; Zidan, Haidy E.; Sabbah, Norhan A.; Karam, Nehad Ahmed; Alzahrani, Saleh

doi:10.1016/j.cellimm.2013.08.001

Cited by 11 publications

(11 citation statements)

References 49 publications

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“…77 Several reports have demonstrated a modifying effect of a SNP in the promoter region of the microbial sensor CD14 on the relationship between endotoxin exposure and atopy. 78–80 Polymorphisms in CD14 have also been shown to interact with microbial exposures 81 and pet exposure, 82 as well as environmental tobacco smoke, 83 on the outcome of allergic disease.…”

Section: Gene-environment Interactions In Atopic Disordersmentioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

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Atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR) and asthma are common atopic disorders of complex etiology. The frequently observed “atopic march” from early AD to asthma and/or AR later in life as well as the extensive comorbidity of atopic disorders, suggests common causal mechanisms in addition to distinct ones. Indeed, both disease-specific and shared genomic regions exist for atopic disorders. Their prevalence also varies among races; for example, AD and asthma have a higher prevalence in African-Americans when compared to European-Americans. Whether this disparity stems from true genetic or race-specific environmental risk factors or both is unknown. Thus far, the majority of the genetic studies on atopic diseases have utilized populations of European ancestry, limiting their generalizability. Large cohort initiatives and new analytic methods such as admixture mapping are currently being employed to address this knowledge gap. Here we discuss the unique and shared genetic risk factors for atopic disorders in the context of ancestry variations, and the promise of high-throughput “-omics” based systems biology approach in providing greater insight to deconstruct into their genetic and non-genetic etiologies. Future research will also focus on deep phenotyping and genotyping of diverse racial ancestry, gene-environment, and gene-gene interactions.

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Section: Gene-environment Interactions In Atopic Disordersmentioning

confidence: 99%

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Gupta

Johansson

Bernstein

et al. 2016

Journal of Allergy and Clinical Immunology

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“…All 18 studies [11,17–19,22,23,33,35–38,42,44,47,48,50,51] containing 7029 subjects reported the association between CD14 −159C/T polymorphism and atopic asthma risk. No statistically significant association of CD14 −159C/T polymorphism and atopic asthma risk was identified in dominant model (TT+TC vs CC: OR = 0.95, 95% CI = 0.84–1.06, P = 0.351) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 7 case–control studies [11,17,22,23,33,36,47] conducted among nonatopic asthma were included in this meta-analysis. Overall, the pooled results indicated that there was no significant relationship of CD14 −159C/T and nonatopic asthma risk in dominant model (TT+TC vs CC: OR = 1.05, 95% CI = 0.82–1.33, P = 0.700) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Yang

Zhou

et al. 2016

Medicine

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Background:It has been reported that the cluster of differentiation 14 (CD14) gene −159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association.Methods:A systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI), and Wan fang databases was conducted up to August 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. We used I2 to assess heterogeneity, and a funnel plot and Egger test to assess publication bias.Results:In total, 34 studies involving 15,641 subjects were included in this meta-analysis. There was a statistically significant association between CD14 −159C/T polymorphism and asthma risk observed in dominant model (TT+TC vs CC: OR = 0.86, 95% CI = 0.77–0.97, P = 0.012) and codominant model (TC vs CC: OR = 0.88, 95% CI = 0.78–0.99, P = 0.035) in adults. However, there may be no significant association between CD14 159C/T and atopic and nonatopic asthma risk.Conclusion:In summary, the overall results suggested that the CD14 −159C/T variant may decrease the risk of asthma susceptibility in adults. However, no significant association between CD14 159C/T and atopic and nonatopic asthma susceptibility was identified. More studies with larger sample size are needed to validate the findings from this study.

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“…Our study however found no correlation between passive smoking and elevated IgE in either atopic or non-atopic adolescents, but in atopics passive smoking showed a borderline significant effect on sCD14 levels. This effect might be explained by chronic exposure to bacterial endotoxins in cigarette smoke and by gene-smoking interaction (34,35).…”

Section: Discussionmentioning

confidence: 99%

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

Prester

Varnai

Macan

2015

Archives of Industrial Hygiene and Toxicology

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The CD14 receptor is expressed on the surfaces of monocytes, macrophages, and, to a lesser extent, of activated granulocytes and B lymphocytes (mCD14). It also exists in soluble form in the serum (sCD14), in which it binds microbial compounds and indoor allergens. The objectives of this study were to see whether serum sCD14 concentrations could be used as a marker of atopic disorders and to estimate the effects of environmental factors (tobacco smoke exposure, childhood residence in urban or rural areas, and having a pet) on sCD14 and IgE values. Mass fraction of sCD14 and total IgE were determined in the sera of atopic (N=53) and non-atopic (N=35) participants using the standard enzyme-linked immunosorbent assay. Exposure to pets and environmental tobacco smoke was estimated based on the International Study of Asthma and Allergies in Childhood questionnaire (ISAAC). Median sCD14 concentration was significantly lower in atopic than in non-atopic girls (3.49 vs. 3.83 μg mL -1 ; p<0.010). The number of smokers at home positively correlated with the sCD14 level in atopics, and urban atopics had significantly lower sCD14 levels than rural atopics (3.47 vs. 3.92 μg mL -1 , p=0.028). Median total IgE concentration was significantly lower in atopic pet owners than in atopics with no pets (161 vs. 252 kIU L -1 ; p=0.021). In conclusion, while sex and environmental factors might be involved in sCD14 expression, particularly in atopics, we found no correlation between sCD14 and total IgE concentrations. The usefulness of sCD14 as a marker of atopic disorders should be investigated further, particularly in relation to the severity of allergic disorders.KEY WORDS: allergy; atopy; environmental tobacco smoke; immunoglobulin E; sCD14; pets Prester Lj, et al. Soluble CD14 and total IgE in the serum of atopic and non-atopic adolescents in relation to environmental factors: a pilot study Arh Hig Rada Toksikol 2015;66:41-49

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CD14 tobacco gene–environment interaction in atopic children

Cited by 11 publications

References 49 publications

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry

Association of CD14 −159 (−260C/T) polymorphism and asthma risk

Soluble CD14 and total IgE in the serum of atopic and nonatopic adolescents in relation to environmental factors: a pilot study / Topivi receptor CD14 i ukupni IgE u serumu mladih atopičara odrasle dobi u ovisnosti o čimbenicima iz okoliša: pilot istraživanje

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