2009
DOI: 10.1016/j.radonc.2009.06.034
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CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell lines HCT-116

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Cited by 47 publications
(30 citation statements)
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“…Because others questioned the validity of CD133 as a SLCCs marker [12], we incorporated another reported marker, CD44 [13,14], to further define SLCCs in HCT116 cells. We examined the expression of CD133 and CD44 in HCT116 cells by flow cytometry.…”
Section: Resultsmentioning
confidence: 99%
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“…Because others questioned the validity of CD133 as a SLCCs marker [12], we incorporated another reported marker, CD44 [13,14], to further define SLCCs in HCT116 cells. We examined the expression of CD133 and CD44 in HCT116 cells by flow cytometry.…”
Section: Resultsmentioning
confidence: 99%
“…And CD133 ? cells were found not to be radioresistant in HCT116 colon cancer cells [12]. These data challenged the view that CD133 was an effective marker of colon SLCCs.…”
Section: Introductionmentioning
confidence: 90%
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“…However, the validity of surface protein CD133 as a CSC marker was questioned [12,13,41]. Besides CD133, CD44, CD24, CD166 and ESA have been used individually or in combination for isolation and enrichment of colon CSCs [6][7][8]15,42].…”
Section: Discussionmentioning
confidence: 99%
“…However, Shmelkov et al [12] argued that expression patterns of CD133 were ubiquitous in differentiated epithelial cells and were not restricted to the CSC fraction in metastatic colon cancers. Further, CD133 + HCT116 colon cancer cells were found not to be radio resistant [13]. These data challenged the view that CD133 was an effective marker of colon CSCs.…”
Section: Introductionmentioning
confidence: 95%