CD133 and CD166 as stem cell markers for predicting the possibility of developing prostatic cancer in cases of benign prostatic hyperplasia

Noel, Khalida I.; Ibraheem, Mustafa M.; Ahmed, Basim S.; Hameed, Ahmed F.; Khamees, Nibras H.; Akkila, Sameh S.

doi:10.13005/bpj/1769

Cited by 3 publications

(2 citation statements)

References 64 publications

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“…Recently, contradictory information about the accuracy of employing CD133 as a marker for CSCs identification and/or isolation has emerged (Glumac and Lebeau, 2018). Our findings showed that malignant cases had a significantly higher percentage and H-score of CD133 expression than the benign cases, agreeing with the findings of O'Brien et al, (2007) and Noel et al, (2019) which also showed that CD133 expression is lower in benign tissues than malignant tissue.…”

Section: Gc Ranks Fourth Among Cancer-related Fatalitiessupporting

confidence: 88%

Immunohistochemical Expression of CD90, CD133, and TPM1 in Relation to Gastric Cancer and H. pylori Association

Gamal,

Ashraf,

Hesham

et al. 2023

Asian Pac J Cancer Prev

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Background: Gastric cancer (GC) is the second most common cause of cancer-related death worldwide. Multiple malignancies overexpress CD90, making it a helpful diagnostic and prognostic marker. CD133 is suggested to be related to poor prognosis in GC. Tropomyosin-1 (TPM1) tumor-suppressor gene low expression may predict poor survival in GC. Our study aimed to investigate CD90, CD133, and TPM1 immunohistochemical expression in GC in relation to diagnosis, prognosis, and Helicobacter pylori ( H. pylori ) infection. Methods: 144 paraffin blocks containing gastric cancerous (108 cases), and non-cancerous (36 cases) tissue were analyzed histopathologically for the type of lesion, grade, and stage of malignancy and by using an immunohistochemical assay for studying the expression of CD90, CD133, and TPM1. Data analysis was carried out using the Statistical Package for the Social Sciences (SPSS) version 20.0. Results: The obtained results showed a significantly higher expression of CD90 and CD133 while showing a significantly lower expression of TPM1 in malignant samples compared to benign ones. CD90 was significantly higher in grade-3, stage-3, and N3 (p<0.05), with no significant difference concerning positive and negative H. pylori samples. CD133 percentage and H-score were significantly higher in grade-2 and stage-4 tumors than in other grades and stages, while being insignificantly higher in N3 and H. pylori -positive cases. TPM1 expression levels were significantly downregulated in GC and H. pylori -positive cases (p<0.05). TPM1 downregulation was associated with grade progression, increased depth of invasion, and tumor node metastasis. Conclusion: CD90, CD133, and TPM1 immunohistochemical expression in the gastric biopsy are related firmly to grades and stages of GC as well as H. pylori infection, so they could be of prognostic value. Further studies on a larger sample size are recommended.

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Section: Gc Ranks Fourth Among Cancer-related Fatalitiessupporting

confidence: 88%

Immunohistochemical Expression of CD90, CD133, and TPM1 in Relation to Gastric Cancer and H. pylori Association

Gamal,

Ashraf,

Hesham

et al. 2023

Asian Pac J Cancer Prev

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“…At low concentrations, IL-10 exerts an antitumor effect by different mechanisms, such as activating natural killer cells (NK), lymphocytes T, macrophages, and nitric oxide. In contrast, IL-10 manifests immune system deregulation at high concentrations, which allows the tumor to escape from immune recognition [22], [23]. Therefore, the expected mechanism of exHsp70 action with immune cells in CRC patients is explained in Fig.…”

Section: Discussionmentioning

confidence: 99%

Elevated Extracellular Hsp70 Correlates with Increased IL-1 and IL-10 in Iraqi Patients with Colorectal Carcinoma

Ismaeel,

Obaid,

Al-Saffar

et al. 2023

Iraqi j. cancer med. genet.

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Colorectal cancer (CRC) is the most common cancer in the Iraqi population. Cancerous cells are stressed cells that express large amounts of intracellular and extracellular heat shock proteins to correct for distorted proteins. They also directly affect immune cells and produce large amounts of cytokines. This work aimed to study the association between serum levels of heat shock protein 70 (Hsp70), interleukin 1 (IL-1), and interleukin 10 (IL-10) in CRC patients to highlight the importance of this pathway in patients’ immune status that may affect the progression of CRC. In the current study, an enzyme-linked immune sorbent assay (ELISA) was performed in 20 Iraqi colorectal cancer patients and 20 healthy volunteers to measure serum levels of Hsp70, IL-1α, and IL-10. Serum levels of HSP70, IL-1α and IL-10 were significantly higher in the CRC group than in the healthy control group (38.83 ± 4.7 and 14.88 ± 1.74 ng mL-1), (141.4 ± 23.22 and 46.38 ± 4.4 ng mL-1) and (26.95 ± 10.14 and 1.4 ± 1.07 ng mL-1), respectively, (p < 0.0001). According to these findings of this study, Hsp70 can be used as a prognostic biomarker for CRC and may be useful in identifying patients with an increased risk of immune tolerance and CRC development in Iraqi patients.

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Expression of BAX and eNOS in Rabbit Pancreatic Tissues Injured by Hydrocortisone

Hameed,

Noel,

Shukri

et al. 2024

Al-Rafidain J Med Sci

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Background: There have been cases of acute pancreatitis brought on by steroids, but identifying it is challenging and necessitates careful monitoring. However, according to new research, 3–5% of all cases of illness may be caused by drug-induced acute pancreatitis, making it the third most common cause. Objective: Evaluation of the effect of hydrocortisone injections on pancreatic structure immunohistochemically using BAX and eNOS markers. Methods: White New Zealand female rabbits weighing between 1.2 and 1.5 kg were used, and they were given free access to food. The rabbits were split into six groups, with five animals in each group receiving intramuscular hydrocortisone injections for 14 and 21 days, respectively, at a dose of 5 mg and 20 mg/kg for short and long durations, and two control groups. Results: There was an increase in weight in both long-duration groups (GL1 and GL2) after week 2 of injection when compared to both control and short-duration groups. There was a highly statistical difference in the expression of BAX in both short- and long-duration groups compared to the control group, and there was also a decrease in the expression of BAX when duration increased. Similarly, there was a highly statistical difference in the expression of eNOS in both the GS and GL groups when compared to the control group. Conclusions: The pancreas can be injured by high and low doses of hydrocortisone if used for more than 2 weeks.

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CD133 and CD166 as stem cell markers for predicting the possibility of developing prostatic cancer in cases of benign prostatic hyperplasia

Cited by 3 publications

References 64 publications

Immunohistochemical Expression of CD90, CD133, and TPM1 in Relation to Gastric Cancer and H. pylori Association

Immunohistochemical Expression of CD90, CD133, and TPM1 in Relation to Gastric Cancer and H. pylori Association

Elevated Extracellular Hsp70 Correlates with Increased IL-1 and IL-10 in Iraqi Patients with Colorectal Carcinoma

Expression of BAX and eNOS in Rabbit Pancreatic Tissues Injured by Hydrocortisone

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