CD117+ small cell lung cancer lacks the asp 816→val point mutation in exon 17

Mojica, Wilfrido; Saxena, Rakhee; Starostik, Petr; Cheney, Richard

doi:10.1111/j.1365-2559.2005.02259.x

Cited by 15 publications

(18 citation statements)

References 32 publications

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“…The protein expression in SCLC varies among researchers [6][7][8][9][10][11][12][13][14][15]; the percentage ranges from 30 [15] to 80% [6]. It is reported that KIT expression without KIT gene mutations is due to KIT gene amplification [15].…”

Section: Discussionmentioning

confidence: 99%

“…KIT and PDGFRA mutations are frequent in GIST [19]. With regard to SCLC, almost all reports showed no KIT mutations [11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, one report showed that a few KIT gene mutations were present in SCLC [13], but others identified no mutations of KIT in SCLC [12,14,15]. There have been no reports on PDGFRA protein in SCLC, but one report investigated the PDGFRA gene in SCLC [15].…”

Section: Introductionmentioning

confidence: 94%

“…In SCLC, it is known that SCLC frequently shows KIT protein [6][7][8][9][10][11][12][13][14][15]. In addition, one report showed that a few KIT gene mutations were present in SCLC [13], but others identified no mutations of KIT in SCLC [12,14,15].…”

Section: Introductionmentioning

confidence: 99%

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Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Terada

2009

Med Oncol

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An extremely rare case of primary small cell carcinoma of the pleura with an emphasis on KIT and platelet-derived growth factor receptor-α (PDGFRA) genes is reported here. A 67-year-old man underwent left testicular orchiectomy because of a testicular tumor. The tumor was immunohistochemically shown to be diffuse large B-cell lymphoma. The patient was treated with chemotherapy and radiation and followed up in our hospital. Eight years after the orchiectomy, the patient (75 years old) developed left pleural tumor and pleural effusion, and a biopsy was performed. The biopsy revealed a medullary malignant tumor consisting of small round and spindle cells. The following three possibilities were considered: recurrent lymphoma, mesothelioma, and small cell carcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin, synaptophysin, CD56, KIT, and PDGFRA, but negative for CEA, cytokeratin 5/6, neuron-specific enolase, chromogranin, CD45, CD3, CD20, CD45RO, CD15, CD30, calretinin, WT-1, B72.3, D2-40, and TTF-1. Therefore, a diagnosis of pleural small cell carcinoma was made. A molecular genetic analysis using PCR-direct sequencing identified no mutations of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes. The patient was treated with chemotherapy (cisplatin) and radiation (50 Gray). The present case is the first reported case of primary small cell carcinoma of the pleura with an examination of KIT and PDGFRA expressions and KIT and PDGFRA gene mutations.

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Section: Discussionmentioning

confidence: 99%

“…KIT and PDGFRA mutations are frequent in GIST [19]. With regard to SCLC, almost all reports showed no KIT mutations [11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Terada

2009

Med Oncol

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“…Recent studies of SCLC revealed that KIT protein is expressed in a significant percentage of SCLC [9][10][11][12][13][14][15][16][17][18]. In addition, one report showed that KIT gene mutations were present in SCLC [16], but others did not [15,17,18].…”

Section: Introductionmentioning

confidence: 99%

Primary small cell carcinoma of the mediastinum: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Terada

2008

Med Oncol

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The author reports herein an extremely rare case of primary small cell carcinoma of the mediastinum with an emphasis on KIT and PDGFRA genes. A 66-year-old man was found to have a mediastinal tumor on a routine chest X-ray examination, and was admitted to our hospital. Imaging modalities revealed a 5 x 4 cm tumor in the middle mediastinum near the bronchial carina. No other tumors were detected in the body including the lungs. Video-assisted thoracoscopy confirmed the mediastinal tumor, and a large incisional biopsy was performed. The tumor was histologically small cell carcinoma. An immunohistochemical study revealed positive reactions for cytokeratins (AE1/3, polyclonal), synaptophysin, neuron-specific enolase, CD56, KIT, and PDGFRA, and negative reactions for chromogranin, CEA, CD45, CD20, and CD3. Ki-67 labeling showed a value of 80%. A molecular genetic analysis using PCR-direct sequencing identified no mutations of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes. The patient received radiation and chemotherapy, and the tumor was fully resolved. The patient has remained free of recurrence for 6 years after the first presentation. The present case is the first reported case of primary small cell carcinoma of the mediastinum with an examination of KIT and PDGFRA expressions and KIT and PDFGRA gene mutations.

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Small cell neuroendocrine carcinoma of the prostate: Incidence and a report of four cases with an examination of KIT and PDGFRA

Terada¹

2011

The Prostate

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Because there have been no reports on the incidence and expressions and mutations of KIT and PDGFRA in small cell neuroendocrine carcinoma (SCNEC) of the prostate, the author surveyed archival specimens of 2,642 prostatic specimens (biopsy, 1,503 cases; transurethral resection, 1,009 cases; prostatectomy, 130 cases). Of these, 706 cases were malignant tumors. In equivocal cases (n = 16) of Gleason 5 adenocarcinoma resembling SCNEC, several neuroendocrine markers were immunohistochemically examined. As the results, four cases of SCNEC were identified; therefore the incidence of SCNEC was 0.5% of all prostatic malignancies. All the four cases were biopsies. The remaining 686 cases were adenocarcinomas. In case 1 (50 years of age), the SCNEC tumor cells were positive for cytokeratin, P504S, synaptophysin, KIT, and PDGFRA, but negative for PSA, neuron specific enolase, CD56, and TTF-1. In case 2 (70 years of age), the tumor cells were positive for cytokeratin, PSA, P504S, chromogranin, and synaptophysin, but negative for neuron-specific enolase, CD56, TTF-1, KIT, and PDGFRA. In case 3 (72 years of age), the SCNEC tumor cells were positive for cytokeratin, PSA, P504S, synaptophysin, CD56, KIT, and PDGFRA, but negative for neuron-specific enolase, chromogranin, and TTF-1. In case 4 (81 years of age), the SCNEC tumor cell were positive for cytokeratin, PSA, P504S, chromogranin, synaptophysin, neuron-specific enolase, KIT, and PDGFRA, but negative for CD56 and TTF-1. A molecular genetic analysis using PCR-direct sequencing showed no mutations of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes in three informative cases of SCNEC. The present cases were the first of prostatic SCNEC with an examination of KIT and PDGFRA expression and KIT and PDFGRA gene mutations.

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CD117+ small cell lung cancer lacks the asp 816→val point mutation in exon 17

Abstract: The absence of mutations in exon 17 of CD117+ SCLC suggests this tumour may respond to therapy with TKI.

Cited by 15 publications

References 32 publications

Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Primary small cell carcinoma of the pleura: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Primary small cell carcinoma of the mediastinum: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA genes

Small cell neuroendocrine carcinoma of the prostate: Incidence and a report of four cases with an examination of KIT and PDGFRA

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