CD105 expression is an independent predictor of survival in patients with endometrial cancer

Erdem, Özlem; Taskiran, Cagatay; Onan, Mehmet Anıl; Erdem, Mehmet; Güner, Haldun; Ataoğlu, Ömür

doi:10.1016/j.ygyno.2006.06.010

Cited by 36 publications

(22 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prognostic value of CD105 and CD31 has been assessed earlier in breast, colon and ovarian carcinomas (Dales et al, 2004;Erdem et al, 2006;Minhajat et al, 2006;Dhakal et al, 2008). High expression of CD105 correlated with increased risk of metastasis in lymph node-positive breast carcinoma patients (Dales et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Expression of endoglin (CD105) in cervical cancer

et al. 2009

View full text Add to dashboard Cite

In this study, we have investigated the role of endoglin (CD105), a regulator of transforming growth factor (TGF)-b 1 signalling on endothelial cells, basic fibroblast growth factor (bFGF) and vascular endothelial growth factor-A (VEGF-A) in cervical cancer. We have measured the number and determined the location of both newly formed (CD105-positive) and the overall number of (CD31-positive) blood vessels, and bFGF and VEGF-A expression using immunohistochemistry in 30 cervical carcinoma specimens. Vascular endothelial growth factor-A mRNA expression was determined using RNA-in situ hybridisation. CD105-and CD31-positive vessels and bFGF-and VEGF-A-positive cells were predominantly present in the stroma. The presence of CD105-and CD31-positive vessels in the stroma did neither correlate with the number of VEGF-A-positive cells nor the number of bFGF-positive cells. However, the number of CD105-and CD31-positive vessels was associated with the expression of VEGF-A mRNA in the epithelial cell clusters (P ¼ 0.013 and P ¼ 0.005, respectively). The presence of CD105-positive and CD31-positive vessels was associated with the expression of avb6 (a TGF-b 1 activator; P ¼ 0.013 and P ¼ 0.006, respectively). Clinically, the number of CD105-positive vessels associated with the number of lymph node metastasis (Po0.001). Furthermore, the presence of CD105-positive vessels within the epithelial cell clusters associated with poor disease-free survival (P ¼ 0.007).

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of endoglin (CD105) in cervical cancer

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Several neoplasm have been investigated for Endoglin CD 105 expression including colorectal cancer [13]; Breast Carcinomas [14]; clear cell renal cell carcinoma [15]; endometrial carcinoma [16]; esophageal adenocarcinoma [17]; gastric carcinoma [18]; laryngeal squamous cell carcinoma [19]; advanced Epithelial Ovarian Cancer [20]; Pancreatic carcinoma [21].…”

Section: Discussionmentioning

confidence: 99%

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Basnaker¹,

Bnvs²

2014

JCDR

View full text Add to dashboard Cite

Objective: To assess the expression of Endoglin and Microvessel Density in clinically normal oral mucosa of non-tobacco and tobacco habituated patients & also histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) patients. Materials and Methods:Twenty cases of clinically normal oral mucosa with tobacco habituation in the form of chewing or smoking, 20 histopathologically confirmed cases of OSCC and twelve normal healthy oral mucosal cases without tobacco habituation in any form, served as control group, were immunohistochemically analysed for expression of Endoglin (CD-105). Chi-square test is used to determine statistical analysis and significance. Result & Conclusion:The finding of 65% of Endoglin CD -105 positivity and microvessel density (MVD) in the mucosal specimens of tobacco users may be attributed as neoangiogenesis or angiogenic squamous dysplasia like phenomenon occurring as important pathological biomarker preceding oral cancer development, and may therefore be useful as a predictive marker of malignancy.

show abstract

“…Endoglin (CD105) was believed to be a promising specifi c marker of newly formed vessels and it has been later shown to be an independent predictor of survival in patients with various tumor types 53 e.g. colorectal cancer 51 , endometrial cancer 65 , prostate cancer 66 . Endoglin is currently confi rmed to be more useful marker than CD31 to identify proliferating endothelium involved in tumor angiogenesis 51 .…”

Section: Discussionmentioning

confidence: 99%

“…Although CD31 expression in group of follicular carcinomas was higher than in follicular adenomas the diff erence was not statistically signifi cant to allow use of this marker to diff erentiate these tumors. Expression of CD 105 exclusively on newly formed vessels has been described in brain, lung, breast, stomach, endometrium and colorectal cancer 51,53,56,65,68,69 . In relation to the earlier presented expression of CD105 in the above-mentioned tumors, the results of our thyroid study were surprising.…”

Section: Discussionmentioning

confidence: 99%

Potential Diagnostic Markers in Nodular Lesions of the Thyroid Gland: An Immunohistochemical Study

Rydlová¹,

Ludvíková²,

Stankova³

2008

BIOMED PAP

View full text Add to dashboard Cite

Aims:The diff erential diagnosis of thyroid nodules in routine practice can be problemmatic for both pathologists and clinicians. Eff ective treatment requires a determination of the biological nature of the lesions. For this reason, ancilliary diagnostic markers along with histological examination of the nodules may be useful. The objective of this study was to evaluate the diagnostic usefulness of novel markers in the diagnosis of hyperplastic and neoplastic nodules.Methods: Forty eight thyroid lesions forming four diagnostic groups including adenomatous goiters (AS), follicular adenomas (FA), follicular (FC) and papillary carcinomas (PC) were examined using standard immunohistochemical methods. Monoclonal antibodies against galectin-3, matrix metalloproteinases (MMPs) -2 and -7 and endothelial markers CD31 and CD105 were used.Results: The cytoplasmatic expression of galectin-3 was positive in all cases of papillary carcinoma. Moreover, statistically signifi cant diff erences between fused groups of benign (AS and FA) and malignant lesions (FC and PC) were found Fischer's exact test (p = 0.0001). No signifi cant diff erences in cytoplasmic expression of MMPs -2 and -7 and in vascular density assessed by using of both endothelial markers between benign lesions and malignant tumors were revealed.Conclusions: Galectin-3 appears to be a useful marker in the diagnosis of papillary carcinoma only. The matrix metalloproteinases-2 and -7 are not helpful in distinguishing hyperplastic and neoplastic thyroid nodules. Endothelial markers do not appear to be suitable for thyroid diff erential diagnosis. A panel of antibodies in the diff erential diagnosis of thyroid nodular lesions would seem most suitable and further studies with larger sets of patients are awaited.

show abstract

CD105 expression is an independent predictor of survival in patients with endometrial cancer

Cited by 36 publications

References 19 publications

Expression of endoglin (CD105) in cervical cancer

Expression of endoglin (CD105) in cervical cancer

Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Potential Diagnostic Markers in Nodular Lesions of the Thyroid Gland: An Immunohistochemical Study

Contact Info

Product

Resources

About