CD Antigens 2001

Mason, David Y.; Pèlegrin, André; Bensussan, Armand; Buckley, Chris; Civin, Curt I.; Clark, Edward A.; Haas, Masja de; Goyert, Sanna M.; Hadam, M.; Hart, Derek N. J.; Hořejšı́, Václav; Meuer, Stefan; Morrissey, James H.; Schwartz‐Albiez, Reinhard; Shaw, Stephen; Simmons, David L.; Uguccioni, Mariagrazia; Schoot, Ellen van der; Vivier, Éric; Zola, Heddy

doi:10.1038/modpathol.3880492

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…The CD15s (sialylated CD15, sialyl Lewis x ) is formed by sialylation of the distal lactosamine unit prior to fucolysation (47). A sulfated CD15 (CD15u) has been recently recognized at the 7th Human Leukocyte Differentiation Antigen Workshop (48). CD15 and CD15s are not specific for hematopoietic cells since the former is expressed on embryonic tissues and adenocarcinomas while the latter is expressed on high-endothelium venules and subcapsular sinuses of lymph nodes.…”

Section: Cd15 Cd15s and Cd15umentioning

confidence: 99%

Surface Antigen Changes during Normal Neutrophilic Development: A Critical Review

Elghetany

2002

Blood Cells, Molecules, and Diseases

196

185

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Section: Cd15 Cd15s and Cd15umentioning

confidence: 99%

Surface Antigen Changes during Normal Neutrophilic Development: A Critical Review

Elghetany

2002

Blood Cells, Molecules, and Diseases

196

185

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“…Today, the differentiation state, lineage specificity, or functional status of a given blood cell population can be precisely determined and communicated based on their antigenic and molecular properties (15). In contrast, the biology and molecular characterization of the stem cell compartments in solid organ tissues suffer from the lack of specific markers that unambiguously label all stem cells and only stemcells, enabling their prospective identification, cultivation, and propagation.…”

Section: Resident Hepatic Stem/progenitor Cellsmentioning

confidence: 99%

The role of stem cells in physiology, pathophysiology, and therapy of the liver

et al. 2006

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The objectives of the present review is to update readers with the rapidly changing concepts in liver stem cell biology and related clinical applications. The liver has adapted to the inflow of ingested toxins by the evolutionary development of unique regenerative properties and responds to injury or tissue loss by rapid division of the mature cells, hepatocytes, and bile duct epithelial cells. Proliferation of the parenchymal cells is regulated by numerous cytokine/growth factor-mediated pathways and is timely synchronized with extracellular matrix degradation and the restoration of the vasculature. The putative role of stem cells in physiology, pathophysiology, and therapy is not yet precisely known but currently is under intensive investigation. Resident hepatic stem/ progenitor cells have been identified in small numbers and implicated in liver tissue repair, when hepatocyte and bile duct replication capacity is exhausted or experimentally inhibited. Several independent reports have suggested that bone marrow cells can give rise to different hepatic epithelial cells types, including hepatic stem cells, hepatocytes, and bile duct epithelium. These observations have resulted in the hypothesis that extrahepatic stem cells, specifically bone marrow-derived stem cells, are an important source for liver epithelial cell replacement, particularly during chronic injury. Most of published data, however, now suggest that they do not play a relevant role in replacement of epithelial cells in any known form of hepatic injury. In vitro differentiation protocols for various adult extrahepatic stem cells might eventually provide valuable sources of cells for transplantation and therapy. Amniotic epithelial stem cells, fetal liver progenitor cells as well as embryonic stem cells currently emerge as alternative stem cell sources and open new possibilities for cellular therapies of liver disease.

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Stem cells in liver regeneration and therapy

2007

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The liver has adapted to the inflow of ingested toxins by the evolutionary development of unique regenerative properties and responds to injury or tissue loss by the rapid division of mature cells. Proliferation of the parenchymal cells, i.e. hepatocytes and epithelial cells of the bile duct, is regulated by numerous cytokine/growth-factormediated pathways and is synchronised with extracellular matrix degradation and restoration of the vasculature. Resident hepatic stem/progenitor cells have also been identified in small numbers in normal liver and implicated in liver tissue repair. Their putative role in the physiology, pathophysiology and therapy of the liver, however, is not yet precisely known. Hepatic stem/progenitor cells also known as "oval cells" in rodents have been implicated in liver tissue repair, at a time when the capacity for hepatocyte and bile duct replication is exhausted or experimentally inhibited (facultative stem/progenitor cell pool). Although much more has to be learned about the role of stem/progenitor cells in the physiology and pathophysiology of the liver, experimental analysis of the therapeutic value of these cells has been initiated. Transplantation of hepatic stem/progenitor cells or in vivo pharmacological activation of the pool of hepatic stem cells may provide novel modalities for the therapy of liver diseases. In addition, extrahepatic stem cells (e.g. bone marrow cells) are being investigated for their contribution to liver regeneration. Hepatic progenitor cells derived from embryonic stem cells are included in this review, which also discusses future perspectives of stem cell-based therapies for liver diseases.

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CD Antigens 2001

Cited by 5 publications

References 31 publications

Surface Antigen Changes during Normal Neutrophilic Development: A Critical Review

Surface Antigen Changes during Normal Neutrophilic Development: A Critical Review

The role of stem cells in physiology, pathophysiology, and therapy of the liver

Stem cells in liver regeneration and therapy

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