CD 38 expression, attachment style and habituation of arousal in relation to trust-related oxytocin release

Kiss, Imre; Levy-Gigi, Einat; Kéri, Szabolcs

doi:10.1016/j.biopsycho.2011.08.005

Cited by 38 publications

(31 citation statements)

References 40 publications

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“…For example, intranasal OT increased positive relative to negative behaviors during a laboratory couple conflict and reduced post-conflict cortisol levels (Ditzen et al, 2009). This potential stress reducing-effect of OT has been further documented by evidence that participants with increased plasma OT healed faster and had a greater number of positive interactions with partners during a 24-h hospital stay (Gouin et al, 2010; see also Kéri and Kiss, 2011; Kiss et al, 2011; see Taylor et al, 2006, for a discussion of OT's role during relaxation vs. stress; see also Feldman et al, 2011). …”

Section: Oxytocin and Socioemotional Functioningmentioning

confidence: 91%

Oxytocin and socioemotional aging: Current knowledge and future trends

Ebner¹,

Maura²,

MacDonald³

et al. 2013

Front. Hum. Neurosci.

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The oxytocin (OT) system is involved in various aspects of social cognition and prosocial behavior. Specifically, OT has been examined in the context of social memory, emotion recognition, cooperation, trust, empathy, and bonding, and—though evidence is somewhat mixed-intranasal OT appears to benefit aspects of socioemotional functioning. However, most of the extant data on aging and OT is from animal research and human OT research has focused largely on young adults. As such, though we know that various socioemotional capacities change with age, we know little about whether age-related changes in the OT system may underlie age-related differences in socioemotional functioning. In this review, we take a genetic-neuro-behavioral approach and evaluate current evidence on age-related changes in the OT system as well as the putative effects of these alterations on age-related socioemotional functioning. Looking forward, we identify informational gaps and propose an Age-Related Genetic, Neurobiological, Sociobehavioral Model of Oxytocin (AGeNeS-OT model) which may structure and inform investigations into aging-related genetic, neural, and sociocognitive processes related to OT. As an exemplar of the use of the model, we report exploratory data suggesting differences in socioemotional processing associated with genetic variation in the oxytocin receptor gene (OXTR) in samples of young and older adults. Information gained from this arena has translational potential in depression, social stress, and anxiety-all of which have high relevance in aging—and may contribute to reducing social isolation and improving well-being of individuals across the lifespan.

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Section: Oxytocin and Socioemotional Functioningmentioning

confidence: 91%

Oxytocin and socioemotional aging: Current knowledge and future trends

Ebner¹,

Maura²,

MacDonald³

et al. 2013

Front. Hum. Neurosci.

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“…Studies indicate that, in response to stress, the insecure attachment is related to a heightened adrenocortical activity, heart rate and skin conductance, which is consistent with the hypothesis that attachment insecurity leads to deficits in emotion regulation (Gander and Buchheim, 2015). The majority of neurophysiological studies of adult attachment use self-report measures (Carpenter and Kirkpatrick, 1996; Kim, 2006; Laurent and Powers, 2007; Rochman et al, 2008; Kiss et al, 2011; Dan and Raz, 2012). Only a few studies use narrative interview measures of attachment like the Adult Attachment Interview (AAI) and the Adult Attachment Projective Picture System (AAP; Beijersbergen et al, 2008; Buchheim et al, 2009; Fraedrich et al, 2010; Holland and Roisman, 2010; Behrens et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of the Adult Attachment Projective Picture System on Oxytocin and Cortisol Blood Levels in Mothers

Krause

Pokorný

Schury

et al. 2016

Front. Hum. Neurosci.

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Oxytocin, a small neuropeptide of nine amino acids, has been characterized as the “hormone of affiliation” and is stimulated, for instance, in mothers when interacting with their offspring. Variations in maternal oxytocin levels were reported to predict differences in the quality of care provided by mothers. In this study, the Adult Attachment Projective Picture System (AAP) as a valid measure to assess attachment representations was used as an activating attachment-related stimulus. We investigated whether the AAP induces a release of oxytocin in mothers with a secure attachment representation and a stress-related cortisol response in mothers with an insecure attachment representation. Therefore, pre-post effects of AAP administration on plasma oxytocin and serum cortisol levels were investigated in n = 44 mothers 3 months after parturition. Oxytocin levels increased from pre to post in the significant majority of 73% participants (p = 0.004) and cortisol decreased in the significant majority of 73% participants (p = 0.004). Interestingly, no association between alterations in oxytocin and cortisol were found; this suggests taking a model of two independent processes into considerations. These results show that the AAP test procedure induces an oxytocin response. Concerning the results within the four AAP representation subgroups, our hypothesis of a particularly strong increase in oxytocin in secure mothers was not confirmed; however, in secure mothers we observed a particularly strong decrease in cortisol. Effect sizes are reported, allowing the replication of results in a larger study with sufficient sample size to draw final conclusions with respect to differences in OT and cortisol alterations depending on attachment representation. When interpreting the results, one should keep in mind that this study investigated lactating mothers. Thus, the generalizability of results is limited and future studies should investigate non-lactating healthy females as well as males and include a control stimulus condition.

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“…They showed that a social challenge requiring trust, but not a cognitive challenge, was associated with an increase in oxytocin levels. Moreover, only the oxytocin response to the trust challenge was associated with efficient habituation of physiological arousal (Kéri and Kiss, 2011; Kiss et al, 2011). As a last example, intranasal oxytocin increased self-perceived trust only in participants who reported negative mood after social rejection, which was interpreted as motivating social support seeking (Cardoso et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The role of oxytocin in familiarization-habituation responses to social novelty

et al. 2013

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Stress or arousal responses to novel social contexts ease off when individuals get familiar with the social context. In the present study we investigated whether oxytocin is involved in this process of familiarization-habituation as oxytocin is known to increase trust and decrease anxiety. Fifty-nine healthy female subjects took part in the same experimental procedure in two sessions separated by 4 weeks. In the first (novelty) session state trust scores were significantly positively correlated with salivary oxytocin levels while in the second (familiarity) session state trust scores were significantly negatively correlated with salivary oxytocin levels. In a path model oxytocin was associated with increased trust in the novelty session and trust was associated with decreased oxytocin levels in the familiarity session. The results are consistent with the idea that oxytocin decreases stress-to-novelty responses by promoting familiarization to novel social contexts.

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CD 38 expression, attachment style and habituation of arousal in relation to trust-related oxytocin release

Cited by 38 publications

References 40 publications

Oxytocin and socioemotional aging: Current knowledge and future trends

Oxytocin and socioemotional aging: Current knowledge and future trends

Effects of the Adult Attachment Projective Picture System on Oxytocin and Cortisol Blood Levels in Mothers

The role of oxytocin in familiarization-habituation responses to social novelty

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