CD 105 As Prognostic Factors in Advanced Stage Breast Cancer Patients

Hermansyah, Dedy; Albar, Zafiral Azdi; Purwanto, Denni Joko; Sari, Lenny; Putri, Risky Ifandriani

doi:10.15562/bmj.v6i1.554

Cited by 2 publications

(3 citation statements)

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“…1,6 Metastasis kelenjar getah bening dianggap sebagai faktor prognostik yang paling penting pada kanker payudara. 7 Beberapa penelitian menunjukkan hasil bahwa LVD berhubungan dengan LVI dan metastasis kelenjar getah bening. 4,8,9 Penelitian Kanngurn S et al, [10] menunjukkan bahwa tidak terdapat hubungan signifikan antara LVD dengan metastasis kelenjar getah bening regional pada karsinoma payudara.…”

Section: Pendahuluanunclassified

“…19 Metastasis kelenjar getah bening dianggap sebagai faktor prognostik yang paling penting pada kanker payudara. 7 Sebagian besar karsinoma payudara pertama kali bermetastasis ke kelenjar getah bening regional melalui aliran limfatik. 1,2 Hal ini sesuai dengan studi yang dilakukan oleh Ran S et al, dalam studi tambahan yang secara kolektif melibatkan lebih dari 3.000 pasien yang menunjukkan bahwa frekuensi invasi limfatik 2-3 kali lebih tinggi dibandingkan dengan invasi pembuluh darah.…”

Section: Pembahasanunclassified

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Hubungan Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia

Simbolon¹,

Dewi²,

Sriwidyani³

et al. 2021

Intisari Sains Medis

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Background: Lymph Node Metastasis (LNM) is considered the most important prognostic factor in breast cancer. The progress of lymphatic metastasis is thought to involve the proliferation of lymphatic vessels (lymphangiogenesis), Lymph Vessel Invasion (LVI), and lymph node metastasis step by step. This study aims to evaluate the association between LVD with LVI and regional LNM in invasive breast carcinoma of no special type. Methods: This study used a cross-sectional analytical study, using a sample of 38 paraffin-embedded tissue from the patient with invasive breast carcinoma of no special type in Sanglah General Hospital, Bali, Indonesia, in 2018. The sample will be used to assess LVD and LVI by D2-40 immunohistochemistry. Expression of D2-40 with vigorous-intensity was evaluated on the membrane and cytoplasm of lymphatic endothelial cells to determine the definition of lymphatic vessels. Lymph vessel density was determined by counting the Latar Belakang: Metastasis Kelenjar Getah Bening (KGB) dianggap sebagai faktor prognostik yang paling penting pada kanker payudara. Perkembangan metastasis limfatik diduga melibatkan proliferasi pembuluh limfatik (limfangiogenesis), Lymph Vessel Invasion (LVI) atau invasi limfatik, dan metastasis kelenjar getah bening secara bertahap. Penelitian ini bertujuan untuk mengevaluasi hubungan antara Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik. Metode: Penelitian ini menggunakan metode analitik number of lumens of peritumoral lymphatic vessels in five fields of view with the densest lymphatic vessel lumen using a Leica microscope (DM750, 400x, area 0.225mm2). Data were analyzed using SPSS version 24 for Windows. Results:The LVD cut-off value is 16.5 lymphatic vessel lumens/0.225 mm2 (65.4% for sensitivity and area Under the Curve (AUC)=70.2%). Then cases were classified into the category of high LVD (≥16,5 lymphatic vessel lumen/0,225 mm 2 ) and low LVD (<16.5 lymphatic vessels lumen/0,225 mm 2 ). The study found a statistically significant association between LVD and lymph vessel invasion (PR=3.6; p=0.043; 95%CI=0.88-14.78) and regional lymph node metastases (PR =1.7; p=0.02; 95%CI=1. 03-2.79). Conclusion:This study proved an association between LVD with lymph vessel invasion and regional lymph node metastases. potong lintang dengan sampel 38 blok parafin dari pasien karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia tahun 2018. Penilaian LVD dan LVI dengan pulasan imunohistokimia D2-40. Ekspresi D2-40 dengan intensitas yang kuat dievaluasi pada membran dan sitoplasma sel endotel limfatik untuk menetapkan definisi pembuluh limfatik. Lymph vessel density ditentukan dengan menghitung jumlah lumen pembuluh limfatik peritumoral pada lima lapangan pandang yang memiliki lumen pembuluh limfatik terpadat, menggunakan mikroskop Leica (DM750, 400x, luas area 0,225mm 2 ). Data dianalisis

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Section: Pendahuluanunclassified

Section: Pembahasanunclassified

Hubungan Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia

Simbolon¹,

Dewi²,

Sriwidyani³

et al. 2021

Intisari Sains Medis

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“…3 Distant metastasis is still the leading cause of death in patient with breast cancer. 4 The majority of breast cancer patients with distant metastasis have lower survival rate although these patients were provided with appropriate treatment. According to American Cancer Society, the survival rate of most patients with stage III breast cancer are 84%, meanwhile patients with stage IV breast cancer only have 19% survival rate.…”

Section: Introductionmentioning

confidence: 99%

Comparison of diagnostic validity between mitotic activity index and Ki-67 expression as predictor for breast cancer in distant metastasis

et al. 2019

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Background: One particular cause of death from breast cancer is distant metastasis. In this study, we calculate and compare diagnostic value of Mitotic Activity Index (MAI) and Ki-67 expression in predicting distant metastasis.Methods: Study was conducted in Sanglah Hospital from January 2017 to February 2019. All histopathology results from open biopsy are examined, thus MAI and Ki-67 values were obtained. We divided this into 2 groups: MAI high (≥20/HPF), low (<20/HPF) and Ki-67 high (≥20%) and low (<20%). We compared with distant metastasis event as gold standard, obtained from radiology examination. We count all diagnostic characteristics (sensitivity, specificity, positive and negative predictive value, accuracy, and likelihood ratio). We compared these diagnostic validities from data area under curve (AUC) with p value <0.005 considered to be statistically significant.Results: A total of 173 breast cancer patients were participated in this study, 92 of them had distant metastasis (53.2%) and 81 patients didn’t have any distant metastasis (46.8%). MAI had relative high specificity (82.7%) and Ki-67 had fair sensitivity values (69.6%). There are 0.08 point AUC differences between these two variables. With p value higher than 0.05 (0.06), it can be summarized that these two variables are not different significantly and statistically.Conclusions: There is not any statistically significant difference between these two markers in predicting distant metastasis in breast cancer. We hope other researcher interest into exploring more about these markers and their function.

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CD 105 As Prognostic Factors in Advanced Stage Breast Cancer Patients

Cited by 2 publications

References 0 publications

Hubungan Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia

Hubungan Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia

Comparison of diagnostic validity between mitotic activity index and Ki-67 expression as predictor for breast cancer in distant metastasis

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