CCXXXIX.—The factors controlling the formation of some derivatives of quinoline, and a new aspect of the problem of substitution in the quinoline series

An Easy Synthesis of Enaminones in Water as Solvent

“…5 However, the generally employed method for the preparation entails the reaction between ammonia or a primary or secondary amine with 1,3-dicarbonyl compound in benzene solution with azeotropic removal of the water formed. [6][7][8][9][10] We report here, a simple procedure for the synthesis of benamino esters and enaminoketones (1) starting from bketoesters or 1,3-diketones and primary amines in water as solvent (Scheme 1). The main advantages of this methodology are: (a) the reaction is simple to perform; (b) the reaction occurs at room temperature; (c) the yields are good to high, (d) acid catalysis is not necessary, (e) the reaction works for a variety of primary amines; and (f) purification of the enaminones is not necessary.…”

Synthesis of N‐Substituted Condensed Tetrahydropyridine‐Based Enaminones via Palladium‐Catalyzed Intramolecular C–N Cross‐coupling

“…(Aniline): The procedure was adopted from Reference and slightly modified. The mixture of aniline (1 eq.)…”

CoFe2O4@SiO2@Co(III) Salen Complex: A Magnetically Recyclable Heterogeneous Catalyst for the Synthesis of Quinoline Derivatives in Water

“…Chemists are considerably eager to the synthesis of quinolines due to the contribution of their oxygen heterocycles to potential antimalarial, antibacterial, antiasthmatic, antihypertensive, anti‐inflammatory, antiplatelet and tyro kinase PDGF‐RTK inhibiting properties . Although different methods including the Skraup, Conrad–Limpach–Knorr,, Pfitzinger,, Friedländer,, and Combes, have been reported for the synthesis of quinolines but the Friedländer condensation is the method which is still a popular method for the synthesis of quinolone derivatives, which in, 2‐amino benzophenone condenses with ketones or diketones to yield quinolines . Nevertheless, for the efficient preparation of heterocycles containing quinolone fragment, the development of new synthetic methods is, therefore, an interesting challenge.…”