CCR5Δ32 and HLA allele diversity in bone marrow donors from southern Brazil
Bruna Kulmann-Leal,
Joel Henrique Ellwanger,
Ana Cristina Arend
et al.
Abstract:Transplantation of stem cells derived from donors with CCR5Δ32 homozygous genotype is a potential strategy to achieve both the control of malignant hematological disease as well as sustained remission of the HIV infection, and researchers in different countries are looking for CCR5Δ32 homozygous donors to replicate such a ‘double-target’ strategy. We determined the frequency of the CCR5Δ32 variant in a sample of 1,398 bone marrow donors from Rio Grande do Sul State, Brazil. This study also evaluated whether
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