CCR5 contributes to adverse outcomes during malaria in pregnancy

Cariaco, Yusmaris; Durán-Rodriguez, Andrea Tatiana; Almeida, Marcos Paulo Oliveira; Silva, Neide Maria

doi:10.1016/j.cyto.2022.156110

Cited by 1 publication

(1 citation statement)

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“…More information on the role of CCR5 in malaria needs to be better understood. [ 49 ] CCR5 is a very important gene that plays an essential role in all the above diseases. Studies that focus on CCR5 are required in an African population.…”

Section: Chemokine Receptormentioning

confidence: 99%

Host Genetic Impact on Infectious Diseases among Different Ethnic Groups

Naidoo,

Arumugam,

Ramsuran

2023

Advanced Genetics

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Infectious diseases such as malaria, tuberculosis (TB), human immunodeficiency virus (HIV), and the coronavirus disease of 2019 (COVID‐19) are problematic globally, with high prevalence particularly in Africa, attributing to most of the death rates. There have been immense efforts toward developing effective preventative and therapeutic strategies for these pathogens globally, however, some remain uncured. Disease susceptibility and progression for malaria, TB, HIV, and COVID‐19 vary among individuals and are attributed to precautionary measures, environment, host, and pathogen genetics. While studying individuals with similar attributes, it is suggested that host genetics contributes to most of an individual's susceptibility to disease. Several host genes are identified to associate with these pathogens. Interestingly, many of these genes and polymorphisms are common across diseases. This paper analyzes genes and genetic variations within host genes associated with HIV, TB, malaria, and COVID‐19 among different ethnic groups. The differences in host–pathogen interaction among these groups, particularly of Caucasian and African descent, and which gene polymorphisms are prevalent in an African population that possesses protection or risk to disease are reviewed. The information in this review could potentially help develop personalized treatment that could effectively combat the high disease burden in Africa.

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Section: Chemokine Receptormentioning

confidence: 99%