CCL5/RANTES in ANCA-associated small vessel vasculitis

Capecchi, Riccardo; Manganelli, Stefania; Puxeddu, Ilaria; Pratesi, Federico; Caponi, Laura; Botta, Albert; Puccini, R; Bombardieri, Stefano; Migliorini, Paola

doi:10.3109/03009742.2012.700487

Cited by 2 publications

(2 citation statements)

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“…IP10 is a strong attractant for macrophages and NK cells. RANTES is responsible for the recruitment of T cells, dendritic cells, eosinophils, NK cells, and monocytes to sites of inflammation [42,43]. Two previous studies have shown elevated levels of RANTES in acute IgAV, and one of them has also shown its increase in patients with internal organ involvement compared to patients without organ involvement [15,44].…”

Section: Discussionmentioning

confidence: 99%

“…Our study did not show significant differences in RANTES and IP10 concentration between the groups studied. However, it was shown that chemokines play a role in many inflammatory diseases such as systemic lupus erythematosus, Kawasaki disease, Wegener’s granulomatosis, and Behcet’s disease [ 40 – 42 ]. IP10 is a strong attractant for macrophages and NK cells.…”

Section: Discussionmentioning

confidence: 99%

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Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children

et al. 2019

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Chemokine expression in sera of patients with microscopic polyangiitis and granulomatosis with polyangiitis

Lee,

Yoon,

Lee

et al. 2024

Sci Rep

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We evaluated chemokine expression and its correlation with disease activity in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) (MPA/GPA). Serum CCL2, CCL4, CCL19, CXCL1, CXCL2, and CX3CL1 level in 80 patients were analysed using multiple enzyme-linked immunosorbent assays. Correlations between variables were investigated using Pearson’s correlation analysis, and receiver operator curve analysis was performed to identify optimal CX3CL1 values in determining active disease. Multivariate logistic regression analysis was done to evaluate predictors of active disease. CCL4 (r = 0.251, p = 0.025), CXCL1 (r = 0.270, p = 0.015), and CX3CL1 (r = 0.295, p = 0.008) significantly correlated with BVAS, while CX3CL1 was associated with five-factor score (r = − 0.290, p = 0.009). Correlations were revealed between CCL2 and CCL4 (r = 0.267, p = 0.017), CCL4 and CXCL1 (r = 0.368, p < 0.001), CCL4 and CXCL2 (r = 0.436, p < 0.001), and CXCL1 and CXCL2 (r = 0.518, p < 0.001). Multivariate analysis revealed serum CX3CL1 levels > 2408.92 pg/mL could predict active disease (odds ratio, 27.401, p < 0.001). Serum chemokine levels of CCL4, CXCL1, and CX3CL1 showed association with disease activity and especially, CX3CL1 > 2408.92 pg/mL showed potential in predicting active MPA/GPA.

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CCL5/RANTES in ANCA-associated small vessel vasculitis

Abstract: No abstract availabl

Cited by 2 publications

References 9 publications

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children

Serum levels of selected cytokines [interleukin (IL)-17A, IL-18, IL-23] and chemokines (RANTES, IP10) in the acute phase of immunoglobulin A vasculitis in children

Chemokine expression in sera of patients with microscopic polyangiitis and granulomatosis with polyangiitis

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