CCL20 and CD8A as potential diagnostic biomarkers for HBV-induced liver fibrosis in chronic hepatitis B

Song, Jingru; Liu, Lu; Wang, Zheng; Xie, Dong; Azami, Nisma Lena Bahaji; Lu, Lu; Huang, Yanping; Ye, Wei; Zhang, Qin; Sun, Mingyu

doi:10.1016/j.heliyon.2024.e28329

Cited by 1 publication

(1 citation statement)

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“…Our study highlighted a pronounced inflammatory response in the vehicle group, evidenced by elevated markers like CD4, CD8a, and CD44. CD8a is a potential prognostic and diagnostic marker for inflammatory disorders and tumors, 48 , 49 used to predict severity in chronic rhinosinusitis and as a biomarker for rheumatoid arthritis. 50 CD8a expression is downregulated in a model of bronchopulmonary dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive immune modulation mechanisms of Angong Niuhuang Wan in ischemic stroke: Insights from mass cytometry analysis

Yao,

Ni,

Feng

et al. 2024

CNS Neurosci Ther

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BackgroundAngong Niuhuang Wan (AGNHW, 安宫牛黄丸), is a classical medicinal formula in Traditional Chinese Medicine (TCM) that has been appreciated for its neuroprotective properties in ischemic cerebral injuries, yet its intricate mechanisms remain only partially elucidated.AimsThis study leverages advanced Mass cytometry (CyTOF) to analyze AGNHW's multifaceted immunomodulation effects in‐depth, emphasizing previously underexplored areas.ResultsAGNHW mitigated monocyte‐derived macrophages (MoDM) infiltration in the brain, distinguishing its effects on those from microglia. While the vehicle group exhibited elevated inflammatory markers like CD4, CD8a, and CD44 in ischemic brains, the AGNHW‐treated group attenuated their expressions, indicating AGNHW's potential to temper the post‐ischemic inflammatory response. Systemically, AGNHW modulated fundamental immune cell dynamics, notably augmenting CD8+ T cells, B cells, monocytes, and neutrophil counts in the peripheral blood under post‐stroke conditions. Intracellularly, AGNHW exhibited its targeted modulation of the signaling pathways, revealing a remarked inhibition of key markers like IκBα, indicating potential suppression of inflammatory responses in ischemic brain injuries.ConclusionThis study offers a comprehensive portrait of AGNHW's immunomodulation effects on ischemic stroke, illuminating its dual sites of action—both cerebral and systemic—and its nuanced modulation of cellular and molecular dynamics.

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Section: Discussionmentioning

confidence: 99%