CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

Yasui, Hiroaki; Kajiyama, Hiroaki; Tamauchi, Satoshi; Suzuki, Shiro; Yang, Peng; Yoshikawa, Nobuhisa; Sugiyama, Mai; Nakamura, Kae; Kikkawa, Fumitaka

doi:10.1007/s10585-019-09993-y

Cited by 42 publications

(29 citation statements)

References 43 publications

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“…Giuntoli et al. found elevated levels of MIP-1β in both ascites and serum samples of patients at the time of primary cytoreductive surgery [23] . Taken this together, carboplatin-gemcitabine does not seem to be the chemotherapeutic of choice to be used in combination strategies.…”

Section: Discussionmentioning

confidence: 95%

“…Also carboplatin in monotherapy showed the same unfavorable lower M1/M2 ratio while in serum we detected increased IFNγ levels. Although IFNγ is generally regarded as a proinflammatory cytokine, it has been shown that IFNγ upregulates the expression of PD-L1 in ovarian cancer cells and thereby can inhibit an anti-tumoral immune response [23] . An additional important observation is that the immune modulating effect of dual chemotherapies (carboplatin-paclitaxel or carboplatin-gemcitabine) is not a summation of these effects of the chemotherapies in monotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Type of chemotherapy has substantial effects on the immune system in ovarian cancer

Vankerckhoven

Baert

Riva

et al. 2021

Translational Oncology

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Type of chemotherapy has substantial effects on the immune system in ovarian cancer

Vankerckhoven

Baert

Riva

et al. 2021

Translational Oncology

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“…FLT3 mutations are associated with polyunsaturated fatty acid metabolism, and they play a previously underappreciated role in obesity-related leukemia [22]. CCL2 secreted from cancerassociated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway [23]. CCL2 is highly expressed in M2 macrophages but antagonized by miR-511-3p, and miR-511-3p regulates allergic inflammation and macrophage polarization by targeting CCL2 and its downstream Ccr2/RhoA axis [24].…”

Section: Discussionmentioning

confidence: 99%

Establishment and Evaluation of a 6-Gene Survival Risk Assessment Model Related to Lung Adenocarcinoma Microenvironment

Wang

Zhu

et al. 2020

BioMed Research International

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Objective. A survival risk assessment model associated with a lung adenocarcinoma (LUAD) microenvironment was established and evaluated to identify effective independent prognostic factors for LUAD. Methods. The public data were downloaded from the TCGA database, and ESTIMATE prediction software was used to score immune cells and stromal cells for tumor purity prediction. The samples were divided into the high-score group and the low-score group by the median value of the immune score (or stromal score). The Wilcoxon test was used for differential analysis. GO and KEGG enrichment analysis of differentially expressed genes (DEGs) was performed using “clusterProfiler” of R package. Meanwhile, univariate and multivariate regression analysis was performed on DEGs to construct a multivariate Cox risk regression model with variable gene expression levels as independent prognostic factors affecting a tumor microenvironment (TME) and tumor immunity. Results. This study found that LUAD patients with high immune cell (stromal cell) infiltration had better prognosis and were in earlier staging. Functional enrichment analysis revealed that most DEGs were related to the proliferation and activation of immune cells or stromal cells. A survival prediction model composed of 6 TME-related genes (CLEC17A, TAGAP, ABCC8, BCAN, FLT3, and CCR2) was established, and finally, the 6 feature genes closely related to the prognosis of LUAD were proved. The AUC value of the ROC curve in this model was 0.7, indicating that the model was reliable. Conclusion. Six genes related to the LUAD microenvironment have a predictive prognostic value in LUAD.

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“…Even though CCL2 exhibits angiogenic effects in vivo, the activity is only observed at certain doses but not at higher doses of CCL2 [154]. Nevertheless, there is a series of results suggesting that the CCL2-dependent signalling pathway could promote the survival of tumor cells [155,156] and stimulate metastasis [157][158][159] and angiogenesis [121]. The dual roles of the CCL2/CCR2 axis in cancer development can lead to opposite results, as patients with higher CCL2 or CCR2 expression had significantly better OS in NSCLC [153] but shorter OS and progression-free survival in diffuse large B cell lymphoma (DLBCL) [160], although evidence about the roles of CCL2/CCR2 in DLBCL is limited.…”

Section: Ccl2mentioning

confidence: 99%

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

Thu

Lee

Cho

2020

Cancers

158

131

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Chemokines are chemotactic cytokines that mediate immune cell chemotaxis and lymphoid tissue development. Recent advances have indicated that chemokines and their cognate receptors play critical roles in cancer-related inflammation and cancer progression. On the basis of these findings, the chemokine system has become a new potential drug target for cancer immunotherapy. In this review, we summarize the essential roles of the complex network of chemokines and their receptors in cancer progression. Furthermore, we discuss the potential value of the chemokine system as a cancer prognostic marker. The chemokine system regulates the infiltration of immune cells into the tumor microenvironment, which induces both pro- and anti-immunity and promotes or suppresses tumor growth and proliferation, angiogenesis, and metastasis. Increasing evidence indicates the promising prognostic value of the chemokine system in cancer patients. While CCL2, CXCL10, and CX3CL1/CX3CR1 can serve as favorable or unfavorable prognostic factors depending on the cancer types, CCL14 and XCL1 possess good prognostic value. Other chemokines such as CXCL1, CXCL8, and CXCL12 are poor prognostic markers. Despite vast advances in our understanding of the complex nature of the chemokine system in tumor biology, knowledge about the multifaceted roles of the chemokine system in different types of cancers is still limited. Further studies are necessary to decipher distinct roles within the chemokine system in terms of cancer progression and to validate their potential value in cancer prognosis.

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CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

Cited by 42 publications

References 43 publications

Type of chemotherapy has substantial effects on the immune system in ovarian cancer

Type of chemotherapy has substantial effects on the immune system in ovarian cancer

Establishment and Evaluation of a 6-Gene Survival Risk Assessment Model Related to Lung Adenocarcinoma Microenvironment

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

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