CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection

Ferrigno, Ilaria; Verzellesi, Laura; Ottone, Marta; Bonacini, Martina; Rossi, Alessandro; Besutti, Giulia; Bonelli, Efrem; Colla, Rossana; Facciolongo, Nicola; Teopompi, Elisabetta; Massari, Marco; Mancuso, Pamela; Ferrari, Anna Maria; Pattacini, Pierpaolo; Trojani, Valeria; Bertolini, Marco; Botti, Andrea; Zerbini, Alessandro; Giorgi Rossi, Paolo; Iori, Mauro; Salvarani, Carlo; Croci, Stefania

doi:10.1007/s00011-024-01852-1

Inflamm. Res.

2024

DOI: 10.1007/s00011-024-01852-1

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CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection

Ilaria Ferrigno,

Laura Verzellesi,

Marta Ottone

et al.

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Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)

Qu,

Lu,

Ran

et al. 2024

Mol Med Rep

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Chitinase-3 like-protein-1 (CHI3L1), a glycoprotein belonging to the glycoside hydrolase family 18, binds to chitin; however, this protein lacks chitinase activity. Although CHI3L1 is not an enzyme capable of degrading chitin, it plays significant roles in abnormal glucose and lipid metabolism, indicating its involvement in metabolic disorders. In addition, CHI3L1 is considered a key player in inflammatory diseases, with clinical data suggesting its potential as a predictor of cardiovascular disease. CHI3L1 regulates the inflammatory response of various cell types, including macrophages, vascular smooth muscle cells and fibroblasts. In addition, CHI3L1 participates in vascular remodeling and fibrosis, contributing to the pathogenesis of cardiovascular disease. At present, research is focused on elucidating the role of CHI3L1 in cardiovascular disease. The present systematic review was conducted to comprehensively evaluate the effects of CHI3L1 on cardiovascular cells, and determine the potential implications in the occurrence and progression of cardiovascular disease. The present study may further the understanding of the involvement of CHI3L1 in cardiovascular pathology, demonstrating its potential as a therapeutic target or biomarker in the management of cardiovascular disease.

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Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)

Qu,

Lu,

Ran

et al. 2024

Mol Med Rep

View full text Add to dashboard Cite

show abstract

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CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection

Cited by 1 publication

References 65 publications

Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)

Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)

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