CCL13 and human diseases

Li, Laifu; Dai, Fei; Wang, Lianli; Sun, Yating; Lin, Mei; Yan, Rong; Ye, Fangchen

doi:10.3389/fimmu.2023.1176639

Cited by 13 publications

(8 citation statements)

References 130 publications

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“…CCL13 (MCP4) could induce the chemotaxis of multiple immune cells, including eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells ( 70 ). CCL13 is implicated in asthma, rheumatic diseases, skin conditions (atopic dermatitis and alopecia areata), and cancer ( 71 ). All of these cytokines are positively associated with XP and could potentially serve as novel therapeutic targets in XP.…”

Section: Discussionmentioning

confidence: 99%

Genetic insight into putative causes of xanthelasma palpebrarum: a Mendelian randomization study

Hu,

Liu,

Lian

et al. 2024

Front. Immunol.

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Xanthelasma palpebrarum (XP) is the most common form of cutaneous xanthoma, with a prevalence of 1.1%~4.4% in the population. However, the cause of XP remains largely unknown. In the present study, we used Mendelian randomization to assess the genetic association between plasma lipids, metabolic traits, and circulating protein with XP, leveraging summary statistics from large genome-wide association studies (GWAS). Genetically predicted plasma cholesterol and LDL-C, but not HDL-C or triglyceride, were significantly associated with XP. Metabolic traits, including BMI, fasting glucose, type 2 diabetes, systolic and diastolic blood pressure, were not significantly associated with XP. Furthermore, we found genetically predicted 12 circulating proteins were associated with XP, including FN1, NTM, FCN2, GOLM1, ICAM5, PDE5A, C5, CLEC11A, CXCL1, CCL2, CCL11, CCL13. In conclusion, this study identified plasma cholesterol, LDL-C, and 12 circulating proteins to be putative causal factors for XP, highlighting the role of plasma cholesterol and inflammatory response in XP development.

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Section: Discussionmentioning

confidence: 99%

Genetic insight into putative causes of xanthelasma palpebrarum: a Mendelian randomization study

Hu,

Liu,

Lian

et al. 2024

Front. Immunol.

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“…I - TAC/CXCL11 is a proinflammatory chemokine and increased blood levels have been found in FM and in endometriosis patients ( 79 , 83 , 84 ). The functions of MCP - 4/CCL13 include secretion of proinflammatory cytokines ( 85 ) ; increased serum levels of MCP - 4/CCL13 were found in patients with knee osteoarthritis (OA) and rheumatoid arthritis (RA) ( 86 ). MIP - 3β/CCL19 both promotes inflammation processes and has a homeostatic function ( 79 , 87 ); a fourfold increase was found in FM ( 74 ).…”

Section: Discussionmentioning

confidence: 99%

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content

Gerdle,

Dahlqvist Leinhard,

Lund

et al. 2024

Front. Pain Res.

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ObjectivesThis explorative study analyses interrelationships between peripheral compounds in saliva, plasma, and muscles together with body composition variables in healthy subjects and in fibromyalgia patients (FM). There is a need to better understand the extent cytokines and chemokines are associated with body composition and which cytokines and chemokines differentiate FM from healthy controls.MethodsHere, 32 female FM patients and 30 age-matched female healthy controls underwent a clinical examination that included blood sample, saliva samples, and pain threshold tests. In addition, the subjects completed a health questionnaire. From these blood and saliva samples, a panel of 68 mainly cytokines and chemokines were determined. Microdialysis of trapezius and erector spinae muscles, phosphorus-31 magnetic resonance spectroscopy of erector spinae muscle, and whole-body magnetic resonance imaging for determination of body composition (BC)—i.e., muscle volume, fat content and infiltration—were also performed.ResultsAfter standardizing BC measurements to remove the confounding effect of Body Mass Index, fat infiltration and content are generally increased, and fat-free muscle volume is decreased in FM. Mainly saliva proteins differentiated FM from controls. When including all investigated compounds and BC variables, fat infiltration and content variables were most important, followed by muscle compounds and cytokines and chemokines from saliva and plasma. Various plasma proteins correlated positively with pain intensity in FM and negatively with pain thresholds in all subjects taken together. A mix of increased plasma cytokines and chemokines correlated with an index covering fat infiltration and content in different tissues. When muscle compounds were included in the analysis, several of these were identified as the most important regressors, although many plasma and saliva proteins remained significant.DiscussionPeripheral factors were important for group differentiation between FM and controls. In saliva (but not plasma), cytokines and chemokines were significantly associated with group membership as saliva compounds were increased in FM. The importance of peripheral factors for group differentiation increased when muscle compounds and body composition variables were also included. Plasma proteins were important for pain intensity and sensitivity. Cytokines and chemokines mainly from plasma were also significantly and positively associated with a fat infiltration and content index.ConclusionOur findings of associations between cytokines and chemokines and fat infiltration and content in different tissues confirm that inflammation and immune factors are secreted from adipose tissue. FM is clearly characterized by complex interactions between peripheral tissues and the peripheral and central nervous systems, including nociceptive, immune, and neuroendocrine processes.

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“…The upregulated proteins that were mapped on 'Cytokine-cytokine receptor interaction' in subgroups 1 and 2 were pro-inflammatory (i.e., LAP TGF-beta-1 [66], IL7 [67], CCL5 [68], CXCL6 [69], CXCL1 [70], and CXCL11 [71] for subgroup 1, and IL-1RT1 [72], TNF-R1 [73], TNF-R2 [73], TNFSF13B [74], MCP-1 [75], SKR3 [66], GDF-15 [76], and LTBR [77] for subgroup 2), suggesting subgroups 1 and 2 have a high level of inflammation compared with the remaining subgroup 3. Similarly, the downregulated proteins that were mapped on 'Cytokine-cytokine receptor interaction' in subgroup 3 were also pro-inflammatory cytokines (i.e., IL8 [78], IL18 [79], CCL5 [68], LAP TGF-beta-1 [66], IL7 [67], CXCL6 [69], CXCL1 [70], CXCL5 [80], CCL14 [81], TNFRSF14 [82], TNFRSF9 [83], and MCP-4 [84]), suggesting subgroup 3 has low levels of inflammation compared with the other subgroups.…”

Section: Plasma Mirna Profiles Revealed Three Subgroups Of Schizophre...mentioning

confidence: 96%

Circulating microRNA Profiles Identify a Patient Subgroup with High Inflammation and Severe Symptoms in Schizophrenia Experiencing Acute Psychosis

Miyano,

Mikkaichi,

Nakamura

et al. 2024

IJMS

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Schizophrenia is a complex and heterogenous psychiatric disorder. This study aimed to demonstrate the potential of circulating microRNAs (miRNAs) as a clinical biomarker to stratify schizophrenia patients and to enhance understandings of their heterogenous pathophysiology. We measured levels of 179 miRNA and 378 proteins in plasma samples of schizophrenia patients experiencing acute psychosis and obtained their Positive and Negative Syndrome Scale (PANSS) scores. The plasma miRNA profile revealed three subgroups of schizophrenia patients, where one subgroup tended to have higher scores of all the PANSS subscales compared to the other subgroups. The subgroup with high PANSS scores had four distinctively downregulated miRNAs, which enriched ‘Immune Response’ according to miRNA set enrichment analysis and were reported to negatively regulate IL-1β, IL-6, and TNFα. The same subgroup had 22 distinctively upregulated proteins, which enriched ‘Cytokine-cytokine receptor interaction’ according to protein set enrichment analysis, and all the mapped proteins were pro-inflammatory cytokines. Hence, the subgroup is inferred to have comparatively high inflammation within schizophrenia. In conclusion, miRNAs are a potential biomarker that reflects both disease symptoms and molecular pathophysiology, and identify a patient subgroup with high inflammation. These findings provide insights for the precision medicinal strategies for anti-inflammatory treatments in the high-inflammation subgroup of schizophrenia.

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CCL13 and human diseases

Cited by 13 publications

References 130 publications

Genetic insight into putative causes of xanthelasma palpebrarum: a Mendelian randomization study

Genetic insight into putative causes of xanthelasma palpebrarum: a Mendelian randomization study

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content

Circulating microRNA Profiles Identify a Patient Subgroup with High Inflammation and Severe Symptoms in Schizophrenia Experiencing Acute Psychosis

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