CCL-2 as a possible early marker for remission after traumatic spinal cord injury

Abstract

Our results indicate that peripheral serum analysis is a suitable concept for predicting the patient's potential for neurological remission after TSCI. Furthermore, the initial CCL-2 concentration provides an additional predictive value compared with the NLI (neurological level of injury). Therefore, the present study introduces a promising approach for future monitoring concepts and tracking techniques for current therapies. The results indicate that future investigations with an enlarged sample size are needed in order to develop monitoring, prognostic and scoring systems.

Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review

“…Heller et al . () also found the levels CCL‐2 and CCL‐4 to be significantly lower in the first and 9 h after admission, in patients who went through neurological improvements, while no considerable changes were reported for the levels of and CCL‐3 and CXCL‐5.…”

Evaluation of the clinical effectiveness of bioactive glass (S53P4) in the treatment of non-unions of the tibia and femur: study protocol of a randomized controlled non-inferiority trial

“…To evaluate the predictive power of variables regarding the criterion “consolidation” adjusting for potentially clinically relevant covariates logistic regression models will be set up and constructed via backwards selection. Analogous to our previous studies [ 44 – 46 ], predictive performance will be assessed through estimation of the models AUC (area under the curve) of the corresponding ROC curve and AIC (Akaike information criterion). Continuous variables will be expressed as absolute mean concentrations ± SD (standard deviation) and the level of significance (α) is set at 5%.…”

Combining advantages: Direct correlation of two‐dimensional microcomputed tomography datasets onto histomorphometric slides to quantify three‐dimensional bone volume in scaffolds

“…Normal distribution was assumed for resulting p ‐values >0.05. Analogous to previous studies, all p ‐values quoted are to be interpreted in a descriptive way, as they were not adjusted for multiple testing as this is an exploratory post hoc analysis …”