CCK/Gastrin-like Immunoreactivity in the Goldfish Pituitary: Regulation of Pituitary Hormone Secretion by CCK-like Peptides in Vitro

Himick, Beverly A.; Golosinski, Agata A.; Jönsson, Ann-Cathrine; Peter, Richard

doi:10.1006/gcen.1993.1146

Cited by 48 publications

(20 citation statements)

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“…In mammals, CCK acts as a satiation factor at the levels of the gut and centrally in specific brain regions (61,66). Intraperitoneal or intracerebroventricular injection of CCK acutely suppresses food intake in goldfish, supporting the action of CCK as a satiety factor in fish (27) and stimulates GH release (24). Furthermore, CCK administration reduces the forebrain expression of PSS-I, but it does not affect PSS-II or PSS III levels (11).…”

Section: Discussionmentioning

confidence: 95%

Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide

Canosa¹,

Unniappan²,

Peter³

2005

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Discussionmentioning

confidence: 95%

Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide

Canosa¹,

Unniappan²,

Peter³

2005

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The increase in expression of PSS-I and PSS-III presumably is reflected in increased production of SRIH-14 and [Pro 2 ] SRIH-14 and an increased inhibitory tone on the release of GH at the pituitary level. Other studies have demonstrated that sex steroids, particularly estradiol, increases the GH-releasing actions of gonadotropin-releasing hormone, thyrotropin-releasing hormone [13]and neuropeptide Y [36], and that the GH-releasing actions of gonadotropin-releasing hormone [13], neuropeptide Y [36], bombesin [37]and cholecystokinin [38]are greatest in sexually mature fish with naturally high sex steroid levels. The balance between the increased SRIH-inhibitory tone and the increased stimulatory actions of the various GH-releasing neurohormones results in an overall increase in circulating GH levels.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Expression of Somatostatin Genes by Sex Steroid Hormones in Goldfish Forebrain

Canosa

Lin²,

Peter³

2002

Neuroendocrinology

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Recently, our laboratory has identified three distinct pre-pro-somatostatin (PSS) genes in goldfish brain: PSS-I encodes for somatostatin (SRIH)-14, PSS-II encodes SRIH-28, which contains [Glu¹, Tyr⁷, Gly¹⁰] SRIH-14 at its C-terminus, and PSS-III encodes [Pro²] SRIH-14. In goldfish, increasing levels of the sex steroid estradiol increase the plasma levels of growth hormone (GH). However, whether sex steroids act at the level of the brain to regulate GH release is unclear. In the present study, the effects of sex steroids on the expression of the three PSS genes in goldfish forebrain were examined. The results demonstrate that treatment with estradiol significantly increases the expression of PSS-I and PSS-III genes in both male and female fish. The effects of estradiol were evident after only 2.5 days of treatment. Testosterone treatment increased the expression of PSS-I and PSS-III genes in female but not male fish, and only at the highest dose used. In addition, the effects of testosterone were evident only after treatment for 5 or 10 days and were blocked by an aromatase inhibitor, suggesting that testosterone must be converted to estradiol to exhibit the effect. Neither estradiol nor testosterone treatment had effects on the expression of the PSS-II gene. These results suggest that sex steroids can act either directly or indirectly on the brain to regulate PSS-I and PSS-III gene expression, influencing in turn the regulation of GH secretion.

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“…Specificity of antisense probes was demonstrated by hybridizing adjacent tissue sections with sense probes. To immunocytochemically demonstrate which cells in the pituitary colocalize the antisense signals, adjacent tissue sections were exposed to rabbit anti-carp GtH-II and rabbit anti-carp GH, as previously described (16).…”

Section: Peptidesmentioning

confidence: 99%

Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish ( Carassius auratus )

Illing

Troskie

Nahorniak

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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187

139

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CCK/Gastrin-like Immunoreactivity in the Goldfish Pituitary: Regulation of Pituitary Hormone Secretion by CCK-like Peptides in Vitro

Cited by 48 publications

References 0 publications

Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide

Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide

Regulation of Expression of Somatostatin Genes by Sex Steroid Hormones in Goldfish Forebrain

Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish ( Carassius auratus )

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