“…Thus, endogenous endocrine CCK-8 detected by others (23,35) is most likely a product of peptide degradation during plasma formation. Importantly, CCK-58 is the major intestinal and endocrine form in dogs (8,13), rats (42), and humans (8,9,14), suggesting its biological action should be evaluated and the influence of CCK-58 on feeding patterns should be studied. The importance of this suggestion is indicated by the fact that CCK-8 and CCK-58 show different actions on various physiological processes.…”