CC chemokines in allergic inflammation

Baggiolini, Marco; Dahinden, Clemens A.

doi:10.1016/0167-5699(94)90156-2

Cited by 502 publications

(305 citation statements)

References 53 publications

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“…They perform both beneficial roles in normal host defense against infection and harmful roles in autoimmune diseases [5][6][7]. Chemokines have been shown to mediate inflammatory tissue destruction in a wide variety of human diseases, such as rheumatoid arthritis, myocardial infarction, and adult respiratory distress syndrome [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Chemokine Regulation of Normal and Pathologic Immune Responses

2001

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Chemokines are small basic proteins that are the major mediators of all leukocyte migration. There are at least 46 distinct chemokines, and 19 chemokine receptors, making it easily the largest cytokine family. Chemokines can be both beneficial and harmful, by either stimulating an appropriate immune response to microbial invasion, or by mediating pathologic tissue destruction in many types of human disease. Chemokines have been implicated in the tissue destruction seen in autoimmune diseases, atherosclerosis, allograft rejection, and neoplasia. Chemokines also play essential roles in normal lymphocyte trafficking to primary and secondary lymphoid organs for antigen presentation and lymphocyte maturation. Chemokines also regulate hematopoietic stem and progenitor cell homing and proliferation. Therefore, it is likely that chemokines will become important targets for pharmacologic intervention in a wide variety of human diseases in the future.

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Section: Introductionmentioning

confidence: 99%

Chemokine Regulation of Normal and Pathologic Immune Responses

2001

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“…The chemokines form a superfamily of small (8-10 kDa), inducible, secreted chemotactic cytokines (for reviews see [1][2][3][4][5]). Chemokines such as interleukin-8 (IL-8) that attract mainly neutrophils are mostly members of the ~ subfamily, whereas those such as MCP-1 that attract mainly monocytes belong to the 13 subfamily [1 5].…”

Section: Introductionmentioning

confidence: 99%

“…Although MCP-I is originally reported to be an attractant for monocytes but not for neutrophils or lymphocytes [6], the cytokine has recently been shown to chemoattract T-lymphocytes in addition to monocytes [7,8]. Based on its in vitro and in vivo functions, the correlation of MCP-I expression and the pathologies or pathophysiologies have already been studied in several diseases and are still under investigation in a wide variety of immune and inflammatory diseases [1][2][3][4][5][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Expression of monocyte chemoattractant protein‐1 mRNA and protein in cultured human thyrocytes

et al. 1996

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Monocytes as well as lymphocytes infiltrate in the stroma of thyroid tissue in autoimmune and destructive thyroiditis. Monocyte chemoattractant protein-1 (MCP-I) is a cytokine that attracts T-lymphocytes as well as monocytes. Using human thyrocytes in primary cultures, we show that expression of MCP-1 mRNA and protein is remarkably stimulated by both interleukin-1 (IL-1) and tumor necrosis factor-~ (TNF-ct), and also that interferon-T (IFN-~/) by itself is a weak stimulant but has a synergistic activity with either IL-1 or TNF-c¢, The finding indicates that MCP-1 can be produced by thyrocytes themselves, suggesting a possible role of thyrocytes on accumulation of monocytes and T-lymphocytes to the tissue from the blood in autoimmune and destructive thyroiditis.

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“…The major chemokine IL-8 is a potent chemoattractant and activator of neutrophils (20) and T lymphocytes (21). IL-8 is induced by pro-inflammatory cytokines including TNFa, IL-1b and IL-6 in different cell types such as monocytes, fibroblasts, lymphocytes and keratinocytes (22). Keratinocytes, as well as mast cells, release histamine in the skin (23), and histamine participates in the control of inflammatory responses in keratinocytes (24).…”

Section: Discussionmentioning

confidence: 99%

Increased expression of the histamine H4 receptor following differentiation and mediation of the H4 receptor on interleukin‐8 mRNA expression in HaCaT keratinocytes

Suwa

Yamaura

Sato

et al. 2014

Experimental Dermatology

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Abstract:Recent in vivo studies have demonstrated involvement of the histamine H4 receptor in pruritus and skin inflammation. We previously reported that an H4 receptor antagonist attenuated scratching behaviour and improved skin lesions in an experimental model of atopic dermatitis. We also reported the expression of the H4 receptor in human epidermal tissues. In this study, we investigated the expression of H4 receptor mRNA and the function of the receptor in a culture system that mimics in vivo inflammation on the HaCaT human keratinocyte cell line. Increased expression of the H4 receptor was observed in HaCaT cells following differentiation. Treatment of HaCaT cells with histamine and TNFa enhanced the mRNA expression of interleukin (IL)-8. These increases in expression were significantly inhibited by the H4 receptor antagonist JNJ7777120. Our results indicate that IL-8 mRNA expression might be enhanced by histamine and TNFa via H4 receptor stimulation in keratinocytes.

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CC chemokines in allergic inflammation

Cited by 502 publications

References 53 publications

Chemokine Regulation of Normal and Pathologic Immune Responses

Chemokine Regulation of Normal and Pathologic Immune Responses

Expression of monocyte chemoattractant protein‐1 mRNA and protein in cultured human thyrocytes

Increased expression of the histamine H4 receptor following differentiation and mediation of the H4 receptor on interleukin‐8 mRNA expression in HaCaT keratinocytes

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