CC-chemokine activation in acute pancreatitis: enhanced release of monocyte chemoattractant protein-1 in patients with local and systemic complications

Abstract

Complicated acute pancreatitis is associated with significantly elevated local and systemic concentrations of the CC-chemokine MCP-1. Our results suggest that, among the CC-chemokine members investigated, MCP-1 might play a pivotal role in the pathological mechanism of complicated acute pancreatitis.

Alterations of Adhesion Molecule Expression and Inflammatory Mediators in Acute Lung Injury Induced by Septic and Non-septic Challenges

“…This supports to the clinical finding that both local (intraperitoneal) and systemic levels of MCP-1 increased early in the course of severe acute pancreatitis in humans (20). Furthermore, the increased levels of systemic MCP-1 have been found to be the closest correlation with the development of pancreatic infections and extrapancreatic organ dysfunction (20).…”

“…Furthermore, the increased levels of systemic MCP-1 have been found to be the closest correlation with the development of pancreatic infections and extrapancreatic organ dysfunction (20). We also …”

Practice Guidelines in Acute Pancreatitis

“…First, there have been several retrospective reports suggesting that a delay in surgical necrosectomy and at times a total avoidance of surgery results in less morbidity and mortality than early surgical debridement (55,60,68,(107)(108)(109)138). Secondly, when sterile necrosis is debrided surgically, a common sequela is the development of infected necrosis and the need for additional surgery (55,91,112,138,160). In at least one report, patients so treated had a very high mortality (138).…”

Prediction of severe acute pancreatitis: Current knowledge and novel insights

“…MCP-1 serum concentrations have been shown to display a dramatic increase in patients with AP who develop local complications or remote organ failure. A close correlation has also been found between the incidence of remote organ failure and the degree of MCP-1 level elevation [7,14] . As highlighted earlier, a common single nucleotide polymorphism on the MCP-1 gene is shown to predispose to severe AP.…”