CBFA2T3–ZNF651, like CBFA2T3–ZNF652, functions as a transcriptional corepressor complex

Kumar, Raman; Cheney, Kelly M.; Neilsen, Paul M.; Schulz, Renèe B.; Callen, David F.

doi:10.1016/j.febslet.2010.01.047

Cited by 12 publications

(13 citation statements)

References 11 publications

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“…In breast cancer cell lines ZBTB10 is suppressed by ROS-microRNA27a thereby enhancing ERα alpha expression and mediating estrogen effects [17]. The ZNF652 (17q21.32) locus codes for a DNA binding protein thought to act as a tumor suppressor gene in breast cancer [69], [70], [71] that is also co-expressed with the androgen receptor in prostate cancer [72]. TDGF3 , teratocarcinoma derived growth factor 3, is the only significant region identified on the X chromosome ((Xq22.3).…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

et al. 2012

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Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.8×10−106), PRMT6 (rs17496332, 1p13.3, p = 1.4×10−11), GCKR (rs780093, 2p23.3, p = 2.2×10−16), ZBTB10 (rs440837, 8q21.13, p = 3.4×10−09), JMJD1C (rs7910927, 10q21.3, p = 6.1×10−35), SLCO1B1 (rs4149056, 12p12.1, p = 1.9×10−08), NR2F2 (rs8023580, 15q26.2, p = 8.3×10−12), ZNF652 (rs2411984, 17q21.32, p = 3.5×10−14), TDGF3 (rs1573036, Xq22.3, p = 4.1×10−14), LHCGR (rs10454142, 2p16.3, p = 1.3×10−07), BAIAP2L1 (rs3779195, 7q21.3, p = 2.7×10−08), and UGT2B15 (rs293428, 4q13.2, p = 5.5×10−06). These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only (men p = 2.5×10−08, women p = 0.66, heterogeneity p = 0.003). Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ∼15.6% and ∼8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance.

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Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

et al. 2012

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“…By targeting FOXO3 genes, miR‐155 increases cancer cell viability, and proliferation and by targeting RAS homolog family member A (RhoA) it triggers EMT, metastasis and even BC drug resistance, although the precise mechanism of this requires more research . The downregulation of ZNF652, a potential target of miR‐155, can increase the invasion, and metastasis of BC . Several studies have observed miR‐155‐stimulated cell proliferation, invasion, EMT, and repressed apoptosis through inhibition of the expression of TP53INP1 in BC cells .…”

Section: Introductionmentioning

confidence: 99%

“…3 The downregulation of ZNF652, a potential target of miR-155, can increase the invasion, and metastasis of BC. 54,55 Several studies have observed miR-155-stimulated cell proliferation, invasion, EMT, and repressed apoptosis through inhibition of the expression of TP53INP1 in BC cells. 51,[56][57][58] Moreover, miR-21 and miR-155 have the same effect on common targets in apoptosis pathways such as APAF-1, BID, CASP2, CASP3, CASP6, CASP9, CASP10.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous downregulation of miR‐21 and miR‐155 through oleuropein for breast cancer prevention and therapy

Abtin

Alivand

Khaniani

et al. 2018

J of Cellular Biochemistry

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Breast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti-neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR-21 and miR-155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC. MCF-7 cells were tested with and without oleuropein and the cell viability, apoptosis, and migration were examined. The effect of oleuropein on miR-21 and miR-155 expression was assessed through qRT-PCR. It was found that oleuropein induced apoptosis and retarded cell migration and invasion in a dose-dependent manner in the human MCF7 BC cell line. It was observed that oleuropein significantly decreased expression of both miR-21 and miR-155 over time in a dose-dependent manner. These results demonstrate that oleuropein is a potential therapeutic and preventive agent for BC. Oleuropein exhibits an anti-cancer effect by modulation of tumor suppressor gene expression, which is targeted by oncomiRs.

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“…Location 16q24.3 Protein Member of the "ETO" family. Functions as a transcriptional repressor via interaction with corepressor complexes; do not directly bind DNA, but interacts with transcription factors such as BCL6, PLZF, GFI1, ZNF651 and ZNF652 (Kumar et al, 2010).…”

Section: Cbfa2t3mentioning

confidence: 99%

inv(16)(p13q24) CBFA2T3/GLIS2

Huret¹

2013

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CBFA2T3–ZNF651, like CBFA2T3–ZNF652, functions as a transcriptional corepressor complex

Cited by 12 publications

References 11 publications

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Simultaneous downregulation of miR‐21 and miR‐155 through oleuropein for breast cancer prevention and therapy

inv(16)(p13q24) CBFA2T3/GLIS2

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