CBCL Clinical Scales Discriminate Prepubertal Children with Structured Interview—Derived Diagnosis of Mania from Those with ADHD

Biederman, Joseph; Wozniak, Janet; Kiely, Kathleen; Ablon, Stuart; Faraone, Stephen V.; Mick, Eric; Mundy, Elizabeth; Kraus, Ilana

doi:10.1097/00004583-199504000-00013

Cited by 255 publications

(177 citation statements)

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“…Nevertheless, the somewhat atypical clinical presentation of juvenile-onset BPD, including extreme hyperactivity, moodiness, chronic rather than episodic irritability and prolonged temper tantrums (Geller and Luby 1997), alternating with depressive symptoms and difficulty sleeping at night (Weller et al 1995), differentiates children diagnosed with BPD in our sample from children with ADHD (Biederman et al 1996). Although some of these symptoms-hyperactivity, distractibility, impulsive risk taking-prevail in both BPD and ADHD, testing with standard screening rating scales also show that delinquent and aggressive behavior, somatic complaints, anxiety/depression, and thought problems are far more severe in children with BPD than ADHD (Biederman et al 1995).…”

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

“…24, NO. 4 symptoms-hyperactivity, distractibility, impulsive risk taking-prevail in both BPD and ADHD, testing with standard screening rating scales also show that delinquent and aggressive behavior, somatic complaints, anxiety/depression, and thought problems are far more severe in children with BPD than ADHD (Biederman et al 1995).Significant differences between subjects and controls were not found for any of the metabolites. A near significant difference was seen for myo-inositol in subjects during the manic phase compared to normal controls.…”

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confidence: 94%

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Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

Davanzo

2001

Neuropsychopharmacology

227

130

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This project was designed to compare differences in brain proton spectra between children and adolescents with bipolar disorder (BPD) and gender and age-matched normal controls, and to measure changes in myo-inositol levels following lithium therapy, utilizing in vivo proton magnetic resonance spectroscopy ( 1 H MRS). A single voxel (2x2x2 cm3) was placed in brain anterior (Tondo et al. 1998). Epidemiological data (Lewinsohn et al. 1995), suggest that the prevalence of juvenile-onset BPD may be as common as rates reported in adult populations, although estimates vary widely (Costello et al. 1996). Given the increased frequency of lithium use among children and adolescents (Ryan et al. 1999) there is a clear need to assess the effects of lithium in pediatric populations. Children may have greater lithium resistance than adults (Himmelhoch and Garfinkel 1986;Hsu 1986), and it may take up to six weeks to determine, based on clinical signs and symptoms, whether a child is responding to treatment. Biological markers of treatment response would be extremely useful, particularly in these times of limited inpatient resources. The present study measured the magnetic resonance of myo-inositol and other metabolites with 1 H MRS in pediatric subjects diagnosed with BPD, before and during lithium therapy, with baseline comparison to normal controls individually matched for age and gender. We hypothesized that lithium would have an effect on the :310-825-0469, Fax: 310-206-4446, E-mail: pdavanzo@mednet.ucla.edu Received April 13, 2000; revised August 25, 2000; accepted September 14, 2000. 360 P. Davanzo et al. N EUROPSYCHOPHARMACOLOGY 2001 -VOL . 24 , NO . 4 magnetic resonance of myo-inositol in the anterior cingulate cortex in children with BPD, as measured by in vivo proton magnetic resonance spectroscopy ( 1 H MRS). Secondarily, we postulated that a decrease in myo-inositol signal in response to lithium might be a predictor of treatment efficacy.Lithium has traditionally been the preferred treatment of the manic phase of bipolar illness in adults, children (Geller and Luby 1997), and adolescents (Strober et al. 1995) with BPD. Open-label (Hsu 1986;Carlson et al. 1992;Strober et al. 1995), and one doubleblind placebo-controlled study of adolescents with substance abuse and mania (Geller et al. 1998) suggest that juveniles with BPD may have somewhat reduced benefit from acute lithium therapy compared with adults. Nevertheless, lithium continues to be widely prescribed among children and adolescents with BPD (Geller and Luby 1997) as well as for young patients presenting with excessive irritability (Fava 1997) and extreme affective dysregulation (Vitiello and Stoff 1997).The precise neurobiological mechanisms whereby lithium reduces acute manic excitement and protects against recurrence of illness remain uncertain. It is apparent that lithium exerts an effect on intracellular second-messenger systems in which activated receptorligand complexes stimulate the turnover of inositolcontaining phospholipids (del Rio et ...

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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confidence: 94%

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Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

Davanzo

2001

Neuropsychopharmacology

227

130

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“…Research suggests that BP affects approximately 1% of community adolescents (Lewinsohn et al, 1995), with estimates as high as 6% to 15% in clinical samples (Biederman et al, 1995;Pavuluri et al, 2006). Adolescents with BP exhibit a difficult illness course characterized by prolonged episodes, substantial inter-episodic symptoms, and marked functional impairment .…”

Section: Abstract Bipolar Disorder; Therapy; Psychosocial Treatmentmentioning

confidence: 99%

Dialectical Behavior Therapy for Adolescents With Bipolar Disorder: A 1-Year Open Trial

Goldstein

Axelson

Birmaher

et al. 2007

Journal of the American Academy of Child & Adolescent Psych

221

138

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Objective-To describe an adapted version of dialectical behavior therapy for adolescents with bipolar disorder.Method-The dialectical behavior therapy intervention is delivered over 1 year and consists of two modalities: family skills training (conducted with individual family units) and individual therapy. The acute treatment period (6 months) includes 24 weekly sessions; sessions alternate between the two treatment modalities. Continuation treatment consists of 12 additional sessions tapering in frequency through 1 year. We conducted an open pilot trial of the treatment, designed as an adjunct to pharmacological management, to establish feasibility and acceptability of the treatment for this population. Participants included 10 patients (mean age 15.8 ± 1.5 years, range 14-18) receiving treatment in an outpatient pediatric bipolar specialty clinic. Symptom severity and functioning were assessed quarterly by an independent evaluator. Consumer satisfaction was also assessed posttreatment.Results-Feasibility and acceptability of the intervention were high, with 9 of 10 patients completing treatment, 90% of scheduled sessions attended, and high treatment satisfaction ratings. Patients exhibited significant improvement from pre-to posttreatment in suicidality, nonsuicidal selfinjurious behavior, emotional dysregulation, and depressive symptoms.Conclusions-Dialectical behavior therapy may offer promise as an approach to the psychosocial treatment of adolescent bipolar disorder. Keywords bipolar disorder; therapy; psychosocial treatmentOver the past decade, bipolar disorder (BP) in children and adolescents has gained increasing attention. Research suggests that BP affects approximately 1% of community adolescents (Lewinsohn et al., 1995), with estimates as high as 6% to 15% in clinical samples (Biederman et al., 1995;Pavuluri et al., 2006). Adolescents with BP exhibit a difficult illness course characterized by prolonged episodes, substantial inter-episodic symptoms, and marked functional impairment . High rates of psychosis, comorbidity, and hospitalizations have also been reported in this population . BP onset in adolescence is particularly pernicious due to its associations with drug and alcohol abuse, unprotected sex, and suicide (Brent and Lerner, 1994;Goldstein et al., 2005;McClellan et al., 1993). Evidence suggests the majority of adolescent-onset BP patients experience aCorrespondence to Dr. Tina R. Goldstein, Western Psychiatric Institute and Clinic, 100 North Bellefield Avenue, #463, Pittsburgh, PA 15213; goldsteintr@upmc.edu. Disclosure: The authors have no financial relationships to disclose. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript deteriorating course into adulthood, with poor outcomes including chronic functional impairment and treatment resistance (Strober et al., 1995). Given the projected continuity and morbidity associated with adolescent BP, effective early intervention may minimize the longterm debilitating effects of the illness.Althoug...

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“…Several attempts have been made to bridge the gap between DSM-IV and ASEBA. These studies assessed associations between ASEBA questionnaire scores and the presence of DSM-IV diagnoses [Biederman et al, 1993[Biederman et al, , 1995Chorpita et al, 1998;Connor-Smith and Compas, 2003;Edelbrock and Costello, 1988;Gould et al, 1993;Jensen et al, 1993;Kasius et al, 1997;, or tried to develop new scales for the ASEBA questionnaires that corresponded better with the DSM than the original ASEBA scales [Achenbach and Dumenci, 2001;Achenbach et al, 2003;Chorpita et al, 1998;Connor-Smith and Compas, 2003;.…”

Section: Introductionmentioning

confidence: 99%

Predicting anxiety diagnoses with the Youth Self-Report

Ferdinand

2006

Depress. Anxiety

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Empirical studies that assess which items of the Youth Self‐Report (YSR) are the best predictors of anxiety disorders in adolescents are lacking, whereas several attempts have been made to construct an anxiety scale for the YSR. It is important to gap the bridge between existing YSR and DSM‐IV diagnostic constructs. My objective in this study was to investigate which YSR items or scales can be used best to predict anxiety disorders in adolescents. In a referred 183‐subject sample of 11‐ to 18‐year‐olds, we examined which YSR items and scales predicted DSM‐IV anxiety diagnoses assessed with the Anxiety Disorders Interview Schedule for Children (ADIS‐C). Several items that predicted anxiety disorders were not included in existing anxiety scales of the YSR. Scale scores based on these items were stronger predictors of DSM‐IV anxiety disorders than existing anxiety scales. Testing empirically which YSR items predict DSM‐IV diagnoses may enhance the usefulness of the YSR for predicting anxiety disorders in clinical practice. Depression and Anxiety 24:32–40, 2007. © 2006 Wiley‐Liss, Inc.

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CBCL Clinical Scales Discriminate Prepubertal Children with Structured Interview—Derived Diagnosis of Mania from Those with ADHD

Cited by 255 publications

References 31 publications

Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

Dialectical Behavior Therapy for Adolescents With Bipolar Disorder: A 1-Year Open Trial

Predicting anxiety diagnoses with the Youth Self-Report

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