CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats

Cruz-Martínez, Ana María; Tejas-Juárez, Juan G.; Díaz, Juan Manuel Mancilla; Florán, Benjamí­n; López-Alonso, Verónica Elsa; Escartín-Pérez, Rodrigo Erick

doi:10.1016/j.euroneuro.2018.08.002

Cited by 11 publications

(5 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice that lack the 5‐HT 1B receptor have impaired activation of PVN neurons by fenfluramine, a stimulator of serotonin release and serotonin reuptake inhibitor, and impaired suppression of food intake by 5‐HT 1A/B agonism 32 . Cannabinoids may mediate some of their orexigenic effects by inhibiting serotonin release and reducing serotonergic signaling via the 5‐HT 1A/B receptors in the PVN 89 . Selective 5‐HT 6 receptor antagonism promotes the activation of PVN neurons, which may contribute to the anorexigenic effect of 5‐HT 6 receptor antagonists 90 …”

Section: Functional Organization Of Serotonergic Signaling In Eating Behaviormentioning

confidence: 99%

Serotonin, food intake, and obesity

2021

View full text Add to dashboard Cite

Summary The role of serotonin in food intake has been studied for decades. Food intake is mainly regulated by two brain circuitries: (i) the homeostatic circuitry, which matches energy intake to energy expenditure, and (ii) the hedonic circuitry, which is involved in rewarding and motivational aspects of energy consumption. In the homeostatic circuitry, serotonergic signaling contributes to the integration of metabolic signals that convey the body's energy status and facilitates the ability to suppress food intake when homeostatic needs have been met. In the hedonic circuitry, serotonergic signaling may reduce reward‐related, motivational food consumption. In contrast, peripherally acting serotonin promotes energy absorption and storage. Disturbed serotonergic signaling is associated with obesity, emphasizing the importance to understand the role of serotonergic signaling in food intake. However, unraveling the serotonin‐mediated regulation of food intake is complex, as the effects of serotonergic signaling in different brain regions depend on the regional expression of serotonin receptor subtypes and downstream effects via connections to other brain regions. We therefore provide an overview of the effects of serotonergic signaling in brain regions of the homeostatic and hedonic regulatory systems on food intake. Furthermore, we discuss the disturbances in serotonergic signaling in obesity and its potential therapeutic implications.

show abstract

Section: Functional Organization Of Serotonergic Signaling In Eating Behaviormentioning

confidence: 99%

Serotonin, food intake, and obesity

2021

View full text Add to dashboard Cite

show abstract

“…Hypothalamic neurons are involved in numerous behaviors, such as sleep/wakefulness [157][158][159][160][161][162][163][164][165][166][167][168][169][170] , food intake [171][172][173][174][175][176][177][178][179][180][181] , parental behavior [182][183][184][185][186] and aggression [187][188][189][190][191][192][193][194] . Innate behaviors in particular have been shown to be orchestrated by neural ensembles present in the hypothalamus.…”

Section: Neural Substrates Of Parental Behaviormentioning

confidence: 99%

A neural network for intermale aggression to establish social hierarchy

et al. 2018

View full text Add to dashboard Cite

Intermale aggression is used to establish social rank. Several neuronal populations have been implicated in aggression, but the circuit mechanisms that shape this innate behavior and coordinate its different components (including attack execution and reward) remain elusive. We show that dopamine transporter-expressing neurons in the hypothalamic ventral premammillary nucleus (PMv neurons) organize goal-oriented aggression in male mice. Activation of PMv neurons triggers attack behavior; silencing these neurons interrupts attacks. Regenerative PMv membrane conductances interacting with recurrent and reciprocal excitation explain how a brief trigger can elicit a long-lasting response (hysteresis). PMv projections to the ventrolateral part of the ventromedial hypothalamic and the supramammillary nuclei control attack execution and aggression reward, respectively. Brief manipulation of PMv activity switched the dominance relationship between males, an effect persisting for weeks. These results identify a network structure anchored in PMv neurons that organizes aggressive behavior and, as a consequence, determines intermale hierarchy.

show abstract

“…In leptin-deficient obese mice, CB1-expressing presynaptic neurons change from glutamatergic to predominantly GABAergic in the lateral hypothalamic area, and because CB1 is associated with G i/o protein, this remodeling results in increased orexin-A, an orexigenic peptide (Cristino et al, 2013). In rats, the CB1 activation decreases hypothalamic serotonergic activity, an important satiety signal, and induces disinhibition of GABA release to stimulate food intake (Cruz-Martinez et al, 2018).…”

Section: Endocannabinoid System and The Neuroendocrine Regulation Of Energy Metabolism Endocannabinoid System And The Hypothalamus -Adipomentioning

confidence: 99%

Quality of Life and a Surveillant Endocannabinoid System

et al. 2021

View full text Add to dashboard Cite

The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets.

show abstract

CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats

Cited by 11 publications

References 62 publications

Serotonin, food intake, and obesity

Serotonin, food intake, and obesity

A neural network for intermale aggression to establish social hierarchy

Quality of Life and a Surveillant Endocannabinoid System

Contact Info

Product

Resources

About