CB1 cannabinoid receptor ligands augment the antidepressant-like activity of biometals (magnesium and zinc) in the behavioural tests

Wośko, Sylwia; Serefko, Anna; Szopa, Aleksandra; Właź, Piotr; Wróbel, Andrzej; Właź, Aleksandra; Górska, Jolanta; Poleszak, Ewa

doi:10.1111/jphp.12880

Cited by 7 publications

(4 citation statements)

References 57 publications

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“…They also enhanced the antidepressant-like properties of biometals (i.e. magnesium, 10 mg/kg and zinc, 5 mg/kg) inhibiting the glutamatergic neurotransmission [12]. Additionally, Kruk-Słomka et al [10] reported that all of the CB receptor ligands used in the present experiments augmented the anti-immobility effects of anticholinergic scopolamine (0.3 mg/kg) in the murine FST.…”

Section: Discussionsupporting

confidence: 57%

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Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

et al. 2020

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Background Though there are several classes of antidepressant drugs available on the pharmaceutical market, depression that affects globally over 320 million people is still undertreated. Scientists have made attempts to develop novel therapeutical strategies to maximize effectiveness of therapy and minimize undesired reactions. One of the ideas is use of either dual-action agents or combined administration of two substances that affect diverse neurotransmissions. Thus, we investigated whether the selected CB receptor ligands (oleamide, AM251, JWH133, and AM630) can have an impact on the activity of bupropion and moclobemide. Bupropion belongs to the dual acting drugs, whereas moclobemide is an inhibitor of monoamine oxidase. Methods The mice forced swim test and the tail suspension test were applied in order to determine the potential antidepressant-like activity, whereas the HPLC method was used in order to assess the brain concentrations of the tested antidepressants. Results An intraperitoneal injection of sub-effective doses of oleamide (5 mg/kg), AM251 (0.25 mg/kg), and AM630 (0.25 mg/kg) increased activity of bupropion (10 mg/kg) in both behavioural tests. Effects of moclobemide (1.5 mg/kg) were potentiated only by AM251. These results were not influenced by the hypo-or hyperlocomotion of animals. Conclusion The outcomes of the present study revealed that particularly activation or inhibition of the CB 1 receptor function may augment the antidepressant activity of bupropion, whereas only inhibition of the CB 1 receptor function manages to increase activity of moclobemide. Most probably, an interplay between CB receptor ligands and bupropion or moclobemide takes place at the cellular level.

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Section: Discussionsupporting

confidence: 57%

“…Mice from the control groups were injected with either 1% aqueous solution of Tween and/or saline. The pre-treatment schedules and the tested doses were chosen on the basis of the literature data [10] and our previous experimental projects [6,11,12]. A standard volume of liquid dosage forms (i.e.…”

Section: Drugsmentioning

confidence: 99%

Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

et al. 2020

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“…For example, non-endocannabinoid N-acylethanolamines found in many plants were found inactive for cannabinoid receptors, but nevertheless effective as restorative modulating lipid precursors that modify chronic inflammation in various infective, metabolic, and autoimmune states [ 107 ]. Functional interactions between the endocannabinoid system and essential ion micronutrient ions such as zinc and magnesium may be additive as it was shown in the animal models of depression [ 108 ].…”

Section: Other Dietary Interventions That Target Ecsmentioning

confidence: 99%

Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils

Komarnytsky

Rathinasabapathy

Wagner

et al. 2021

IJMS

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The endocannabinoid system (ECS) consists of endogenous cannabinoids, their receptors, and metabolic enzymes that play a critical homeostatic role in modulating polyunsaturated omega fatty acid (PUFA) signaling to maintain a balanced inflammatory and redox state. Whole food-based diets and dietary interventions linked to PUFAs of animal (fish, calamari, krill) or plant (hemp, flax, walnut, algae) origin, as well as full-spectrum hemp oils, are increasingly used to support the ECS tone, promote healthy metabolism, improve risk factors associated with cardiovascular disorders, encourage brain health and emotional well-being, and ameliorate inflammation. While hemp cannabinoids of THC and CBD groups show distinct but complementary actions through a variety of cannabinoid (CB1 and CB2), adenosine (A2A), and vanilloid (TRPV1) receptors, they also modulate PUFA metabolism within a wide variety of specialized lipid mediators that promote or resolve inflammation and oxidative stress. Clinical evidence reviewed in this study links PUFAs and cannabinoids to changes in ECS tone, immune function, metabolic and oxidative stress adaptation, and overall maintenance of a well-balanced systemic function of the body. Understanding how the body coordinates signals from the exogenous and endogenous ECS modulators is critical for discerning the underlying molecular mechanisms of the ECS tone in healthy and disease states. Nutritional and lifestyle interventions represent promising approaches to address chronic metabolic and inflammatory disorders that may overlap in the population at risk. Further investigation and validation of dietary interventions that modulate the ECS are required in order to devise clinically successful second-generation management strategies.

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“…For instance, administrations of the inverse agonist CB 1 cannabinoid receptor, rimonabant, induces symptoms of anxiety and depression and even suicidal ideation [ 58 - 60 ]. Conversely, antidepressive effects have been found by using CB 1 cannabinoid receptor antagonists [ 61 - 63 ]. In line with the current pharmacological findings, mice lacking the CB 1 cannabinoid receptor display abnormal patterns at different behavioral paradigms associated with mood disorders.…”

Section: The Modulatory Role Of the Endocannabinoid System In Mental ...mentioning

confidence: 99%

The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health

Amatriain-Fernández

Budde

Gronwald

et al. 2021

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: According to the World Health Organization (WHO), 47 million of people display mental health disorders Worldwide. In addition, epidemiological studies have shown that the extension of life expectancy and the increase in aged population will significantly impact in the prevalence of several mental impairments. Although there are strategies for preventing and alleviate mental illnesses such as pharmacological and psychological approaches, limited results have been observed. Thus, the search for new therapeutics for managing psychiatric disorders has explored multiple roads. In recent years, it has been demonstrated that physical activity and exercise promote health benefits. On the other hand, among the neurobiological systems that participate in the genesis and development of mental disruptions, the endocannabinoid system has been suggested as an active player. Supporting this hypothesis, data suggest that the elements comprising the endocannabinoid system, such as the CB1/CB2 cannabinoid receptors, endogenous ligands (N-arachidonoylethanolamine [anandamide, AEA] and 2-arachidonoylglycerol [2- AG]), transporters and the enzymes involved in the biosynthesis and degradation of the AEA and 2-AG, modulate mental diseases. In this review, we discuss that the endocannabinoid system might be considered as a modulator for the positive outcomes of exercise in the management of mental disorders. Clinically, this promising field might be exploited by targeting the elements of the endocannabinoid system aimed to increase the exercise benefits applied to patients with mental illnesses.

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CB1 cannabinoid receptor ligands augment the antidepressant-like activity of biometals (magnesium and zinc) in the behavioural tests

Abstract: The simultaneous modulation of the cannabinoid system and supplementation of magnesium or zinc produce at least additive antidepressant-like effect.

Cited by 7 publications

References 57 publications

Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice

Endocannabinoid System and Its Regulation by Polyunsaturated Fatty Acids and Full Spectrum Hemp Oils

The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health

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