Cavum vergae and psychiatric illness: substantive or serendipity?

Rajasekharan, Chandrasekharan; Karthik, Vijayakumar; Harikrishnan, Muralikrishnan; Lekshmi, Sudhakaran

doi:10.1136/bcr-2018-225511

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…"The septum pellucidum is a thin midline translucent (pellucidum = transparent) plate of two laminae that extends from the anterior part of the body, the genu, and the rostrum of the corpus callosum to the superior surface of the fornix" [21]. It is a membrane with two leaflets that creates a barrier between the lateral ventricles of the brain [16]. In between the leaflets of the membrane is a space which gradually closes and completely disappear within the first year of life [16].…”

Section: Discussionmentioning

confidence: 99%

“…It is a membrane with two leaflets that creates a barrier between the lateral ventricles of the brain [16]. In between the leaflets of the membrane is a space which gradually closes and completely disappear within the first year of life [16]. Cavum septum pellucidum (CSP) is a space formed due to abnormal lack of fusion of the leaflets of the septum pellucidum (SP) [21] [22].…”

Section: Discussionmentioning

confidence: 99%

“…Cavum septum pellucidum (CSP) is a space formed due to abnormal lack of fusion of the leaflets of the septum pellucidum (SP) [21] [22]. Sometimes, CSP occurs concurrently with Cavum vergae (CV) which is a posterior extension of CSP that lies in front of the splenium of corpus callosum and behind the anterior columns of fornix [16]. Both CSP and CV can be found as separate entities without any clinical significance, but studies have suggested that their persistence could result in some abnormalities of the limbic system and some midline structures [23].…”

Section: Discussionmentioning

confidence: 99%

“…Landin-Romero et al reported the presence of CV in adult patients with varying psychiatric disorders who were also said to have low IQ, present late, have deteriorating executive function and difficulties with memory [15]. Rajasekharan et al reported a case of a 38 year old woman with both CSP and CV who presented with Psychotic symptoms that did not respond to the first antipsychotic Open Journal of Psychiatry prescribed [16]. Cases had also been reported of a woman who has late onset Schizophrenia [17] and a boy with treatment resistant Schizophrenia [7] both of which MRI findings reported persistence of CV.…”

Section: Review Of Literaturementioning

confidence: 99%

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Catatonia: Cavum Septum Pellucidum and Vergae, a Cause or a Coincidence?

Gudaji,

Habib,

Yakubu

2023

OJPsych

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Background: Many studies in the 20 th century have reported an association between Schizophrenia and Catatonia. Structural brain abnormalities have also been found in many psychotic illnesses, including schizophrenia and there are findings of association of large ventricles with chronic and deteriorating psychosis. It is possible that a large ventricular system may increase the likelihood of catatonia with a chronic course. Cavum Septum Pellucidum (CSP) and Cavum Vergae (CV) are structural abnormalities that have been associated with Schizophrenia. This is a case report of the presence of persistent CSP and CV in a patient diagnosed with schizophrenia with catatonia. Conclusion: Although there are several reports of the findings of a persistent large CSP and CV in patients with Schizophrenia, it is questionable whether the CSP and CV are the cause of the Catatonia or their occurrence is a mere coincidence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Review Of Literaturementioning

confidence: 99%

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Catatonia: Cavum Septum Pellucidum and Vergae, a Cause or a Coincidence?

Gudaji,

Habib,

Yakubu

2023

OJPsych

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“…CV and CSP may be present as an asymptomatic variation in some individuals. However, several epidemiological studies have suggested that their long-term presence in the brain may lead to developmental abnormalities in midline structures, the limbic system of the brain, and various neuropsychiatric disorders [32]. Studies have been conducted on the relationship with many psychiatric disorders such as schizophrenia and bipolar affective disorder (BAD) (8,9).…”

Section: Introductionmentioning

confidence: 99%

Compare of Brain Anomalies and Psychopathology of Patients in a Psychiatric Clinic: A Retrospective Study

Kose¹

2023

PPD

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Background: In parallel with the development of neuroimaging methods, become increasingly possible to explore the relationship between mental disorders and structural brain lesions. It is aimed to examine the relationship between the clinicalfeatures and psychopathologies of psychiatric patients and their anomalies. Methods: Two hundred-six female patients who were treated in Clinic of Psychiatry, Rize Training and Research Hospital between01/Jan/2016 and 31/Dec/2021 and had brain magnetic resonance imaging (MRI) were included in this study. Sociodemographic and clinical characteristics data form was recorded for each patient. Simultaneously, the size and location of the anomalies were recorded by scanning the brain MRI. Results: When the brain MRI scans of the patients were evaluated, 56% of 206 patients had at least one of the related anomalies. Enlarged Virchow-Robin space (VRS) in 2.4%, mega cisterna magna (MCM) in 14.6%, total empty sella (ES) in 8.3%, partial ES in 27.7%, cavum vergae (CV) in 1.9%, hippocampal remnant cyst (HRC) in 17%and 6.8% had arachnoid cyst (AC) findings. When the sociodemographic data and clinical characteristics of the patients were compared with the brain MRI findings, a significant correlation was found between the presence of MCM and the use of antidepressant medication (p=0.026). A significant correlation was found between the presenceof AC, disease duration and regular treatment history (p=0.0002). No significant correlation was found between otherdata and MRI (p>0.05). Conclusions: In our study, it is noteworthy that a higher rate of anomaly was detected in brain imaging of caseswith a history of psychiatric diagnosisand treatment comparedto the general population.

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An Uncommon Presentation of Septum Pellucidum Anatomical Variations: A Case Report of Generalized Tonic-Clonic Seizure in a Healthy Adult

Parça,

Ataş,

Çelik

et al. 2024

Journal of Emergency Medicine Case Reports

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ABSTRACT: Introduction: The septum pellucidum (SP) is a thin, transparent, dual-membrane structure located between the lateral ventricles of the brain. Incidentally identified through imaging modalities, this variation, while rare, may manifest with symptoms such as neuropsychiatric disorders, headache, dizziness, seizures, nausea, and vomiting. In this report, we present the case of a healthy middle-aged man with CV and CSP, who sought medical attention in the emergency department (ED) due to a generalized tonic-clonic seizure (GTCS). Case Report: A 40-year-old male without any known medical history presented to our emergency department with a GTCS. Considering this as the first seizure, blood and imaging tests were conducted, all of which showed no abnormalities. Non-contrast computed tomography revealed sequel cystic encephalomalacic areas in the left occipital and right frontal cerebral hemispheres, consistent with a parapharyngeal epidermoid cyst, and the presence of cavum septum pellucidum et vergae. Emergency consultation from the neurological clinic was sought, and an electroencephalogram showed no seizure activity. He was subsequently discharged with a recommendation for follow-up at the neurology outpatient clinic. Conclusion: This case prompts critical considerations in the emergency medicine realm regarding the potential relationship between anatomical variations in the septum pellucidum and emergent seizure activity. Keywords: Septum pellucidum, seizure, cavum vargae, emergency

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Cavum vergae and psychiatric illness: substantive or serendipity?

Cited by 5 publications

References 4 publications

Catatonia: Cavum Septum Pellucidum and Vergae, a Cause or a Coincidence?

Catatonia: Cavum Septum Pellucidum and Vergae, a Cause or a Coincidence?

Compare of Brain Anomalies and Psychopathology of Patients in a Psychiatric Clinic: A Retrospective Study

An Uncommon Presentation of Septum Pellucidum Anatomical Variations: A Case Report of Generalized Tonic-Clonic Seizure in a Healthy Adult

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