Cavernous sinus thrombosis in a patient with nephrotic syndrome

Navarro, David; Ferreira, Ana Carina; Viana, Helena; Carvalho, Fernanda; Nolasco, Fernando

doi:10.1007/s13730-017-0260-7

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Venous thromboembolism always happened within the first few months of disease and during relapses. [ 14 ] However, PE as the first manifestation in NS is very rare and, to our knowledge, has not been reported so far. In our case, the first complaint of the patient was hemoptysis, cough and shortness of breath with exertion, no symptoms with respect to NS such as edema were presented at the initial course.…”

Section: Discussionmentioning

confidence: 98%

Chronic thromboembolic pulmonary hypertension as the first manifestation of nephrotic syndrome in a 12-year-old child

et al. 2018

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Rationale:Chronic thromboembolic pulmonary hypertension (CTEPH) is rare in children and determining the underlying etiologies is essential for treatment. Venous thromboembolism, a well-known complication in nephrotic syndrome (NS), always occurrs during the treatment in course of the disease. However, CTEPH as the first manifestation of NS has not been reported till now.Patient concerns:A 12-year-old boy initially complained of hemoptysis, cough and shortness of breath with exertion, any symptoms regarding NS such as edema were not presented. Due to the identification of P2 enhancement, liver enlargement (2 cm below the rib) and jugular vein distension, pulmonary hypertension (PH) was firstly suspected and ultimately confirmed by detection of enlargement of right atrium (RA) and right ventricle (RV) enlargement (RA = 45mm, RV = 30mm), mild tricuspid valve regurgitation (TR) and elevation of pulmonary arterial pressure (63 mmHg) on echocardiogram. In order to search the underlying causes of PH, series of targeted laboratory evaluation and imaging were conducted, and pulmonary arterial embolism (PE) in inferior lobes of double lungs was found on chest contrast-enhanced computed tomography.Diagnosis:NS was unexpectedly discovered by detection of lower serum albumin level (24.4 g/L), severe proteinuria (+++, 4.62 g/24 h) when we were searching for the predisposing factors causing thromboembolism.Interventions and outcomes:After treatment of NS, the symptom regarding shortness of breath with exertion gradually became less apparent and was relieved one month later. Proteinuria and microscopic hematuria also disappeared. Encouragingly, RA and RV dilation, and the pulmonary arterial pressure almost returned to a normal range half a year later, with alleviation of MR.Lessons:CTEPH can occur rarely in children and NS is an important predisposing factor. PE could be the first manifestation of NS. When pediatricians encounter children with PE or CTEPH, NS as the underlying etiology should be considered. Except for renal venous thrombosis, the possibility of PE needs to be paid more attention in children with NS.

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Section: Discussionmentioning

confidence: 98%

Chronic thromboembolic pulmonary hypertension as the first manifestation of nephrotic syndrome in a 12-year-old child

et al. 2018

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“…Slight/mild myocardial muscle degeneration was observed in the heart of treated mice groups as shown in Figure 3a.Stomach and intestines were normal, indicating no structure disorganization in the gastrointestinal tract after extract oral administration. Mild congestion in capillary glomerulus and thrombosis was seen in the kidney of the treated mice groups as shown in Figure 3b; persistence of this condition is life threatening that may lead to kidney injury and other clinical manifestations [25]. Mild focal inflammatory reactions of the liver were also observed in the treated mice shown in Figure 4a as steatosis which occurs due to toxic stress [26].…”

Section: Histopathological Evaluationsmentioning

confidence: 89%

In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae)

2020

International Journal of Medicinal Plants and Natural Products

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Background: Majority of people opt the use of traditional means of treatment especially medicinal plants on the notion of being safe since they are naturally derived. Objective: The study aimed at evaluation of the antidiabetic efficacy of extract and fraction and safety profile of Solanum terminale fruits extract in mice. Methods: Mice were induced diabetes by intraperitoneal injection of freshly prepared alloxan monohydrate 170 mg/kg BW.The diabetic mice were treated once daily with crude extract and methanol fraction (100 mg/kg BW) for 20 days, and FBG were recorded on day 1, 5, 10, 15 and 20. The effects of the extract and fraction on FBG levels of the diabetic mice were evaluated. OECD guidelines were used in assessing the acute oral toxicity of S. terminale fruits extract by single dose of crude extract at 2000 mg/kg BW. Mice were observed for 14 days for their mortality, behavioral and other changes. Before sacrifice, weight of mice and the visceral organs were recorded, and sent for histological evaluations. Results were expressed as mean ± SD, analysed by independent student's t-test, p <0.05 was considered as significant level. Ethical clearance was sought from MUHAS, IRB and animal care followed the EEC Directive of 1986; 86/609/EEC. Results: Crude ethanolic fruit extract of S. terminale and methanolic fraction demonstrated clinical and statistical significant blood glucose lowering efficacy in mice (p<0.05). Neither death nor abnormal changes in behavioral features in tested mice observed at 2000 mg/kg BW of S. terminale crude ethanolic fruit extract. The histological analysis demonstrated some organ derangements at 2000 mg/kg BW of S. terminale crude ethanolic fruit extract. Conclusion: The fruits are nearly safe for use in low doses/consumption. Further work is needed including more antidiabetic screening exhausting other techniques, further toxicological studies, identification of the active compounds, and standardization/formulation of S. terminale fruits products.

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“…Additional MRV screening is frequently necessary as a result [16,17]. CVST has been diagnosed and prognosed with outstanding accuracy by combining cranial MRI and MRV [18].…”

Section: Discussionmentioning

confidence: 99%

Cerebral Venous Sinus Thrombosis (CVST): A Clinically Significant Neurological Condition

Gaur,

Gadkari,

Pundkar

2024

Cureus

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Cavernous sinus thrombosis in a patient with nephrotic syndrome

Cited by 5 publications

References 13 publications

Chronic thromboembolic pulmonary hypertension as the first manifestation of nephrotic syndrome in a 12-year-old child

Chronic thromboembolic pulmonary hypertension as the first manifestation of nephrotic syndrome in a 12-year-old child

In-Vivo Antidiabetic Activity and Safety Profile of Fruits Extract and Fraction of Solanum Terminale Forsk (Solanaceae)

Cerebral Venous Sinus Thrombosis (CVST): A Clinically Significant Neurological Condition

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