Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis

Dolapsakis, Christodoulos; Kranidioti, Eleftheria; Katsila, Sofia; Samarkos, Michael

doi:10.1136/bcr-2018-227302

Cited by 20 publications

(17 citation statements)

References 14 publications

(23 reference statements)

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“…Cavernous sinus thrombosis is a very rare, life-threatening condition. Typically, it is caused by an infection that has spread beyond the face, sinuses, teeth, pharynx, ears, or eyes, or have post-traumatic origin [ 30 , 31 , 32 ]. The course of the disease, blood rheology, and prevention of microcirculatory disorders is important in such patients because the continuation of the process in many cases, delays the sequestration and ineffectiveness of conservative treatment depend on general and local circulatory disorders, thrombosis, and other metabolic changes in patients.…”

Section: Discussionmentioning

confidence: 99%

Complications of COVID-19 in the maxillo-facial region: Clinical case and review of the literature

Boymuradov

Rustamova

Bobamuratova

et al. 2021

Advances in Oral and Maxillofacial Surgery

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COVID-19 is currently causing a pandemic around the world. With the increase in the number of patients, there was a slight increase in the incidence of various complications. In particular, infectious and inflammatory diseases of the face and jaw are observed in patients with COVID-19 in the early infectious stages of the disease, as well as in the late stages. In the previous literature, as a sign or complication of COVID-19 were mentioned cases of changes in the oral cavity - ulcers, rashes, and inflammation of salivary glands. The conditions presented in this article are a serious complication of COVID-19, radically different from the usual course of osteomyelitis, in which the patient has a course with a predominance of long-term, chronic-progressive, atrophic processes. Treatment was somewhat ineffective due to local chronic inflammation (pansinusitis), metabolic, microcirculatory, immune, and coagulation disorders in patients.

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Section: Discussionmentioning

confidence: 99%

Complications of COVID-19 in the maxillo-facial region: Clinical case and review of the literature

Boymuradov

Rustamova

Bobamuratova

et al. 2021

Advances in Oral and Maxillofacial Surgery

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“…There is some discussion about the inter-relationship between infection-induced thrombosis and pre-existing risk factors, such as smoking, lipid levels, and sedentarism, in terms of whether these risk factors directly influence pathogen-driven thrombosis (5). Nevertheless, it is likely that infection promotes the risk of thrombosis in such individuals, although it is important to consider that infection alone is sufficient to drive thrombotic events (7–12). For example, ischemic stroke is associated with acute infections (particularly in the first 3 days after respiratory or urinary tract infection) as are chronic infections such as chronic bronchitis (5).…”

Section: Introductionmentioning

confidence: 99%

Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Beristain‐Covarrubias

et al. 2019

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Thrombosis is a common consequence of infection that is associated with poor patient outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is induced, maintained and resolved are poorly understood, as is the contribution thrombosis makes to host control of infection and pathogen spread. The key difference between infection-associated thrombosis and thrombosis in other circumstances is a stronger inflammation-mediated component caused by the presence of the pathogen and its products. This inflammation triggers the activation of platelets, which may accompany damage to the endothelium, resulting in fibrin deposition and thrombus formation. This process is often referred to as thrombo-inflammation. Strikingly, despite its clinical importance and despite thrombi being induced to many different pathogens, it is still unclear whether the mechanisms underlying this process are conserved and how we can best understand this process. This review summarizes thrombosis in a variety of models, including single antigen models such as LPS, and infection models using viruses and bacteria. We provide a specific focus on Salmonella Typhimurium infection as a useful model to address all stages of thrombosis during infection. We highlight how this model has helped us identify how thrombosis can appear in different organs at different times and thrombi be detected for weeks after infection in one site, yet largely be resolved within 24 h in another. Furthermore, we discuss the observation that thrombi induced to Salmonella Typhimurium are largely devoid of bacteria. Finally, we discuss the value of different therapeutic approaches to target thrombosis, the potential importance of timing in their administration and the necessity to maintain normal hemostasis after treatment. Improvements in our understanding of these processes can be used to better target infection-mediated mechanisms of thrombosis.

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“…En el caso en que las pruebas de susceptibilidad revelen susceptibilidad a la meticilina, la vancomicina debe reemplazarse con oxacilina (2g cada 4 horas IV). La duración de la terapia antibiótica debe ser al menos 3-4 semanas (12). En casos donde el organismo causante de la infección del paciente no sea identificado, se deberá iniciar antibióticos intravenosos de manera empírica con el fin de reducir la mortalidad y las secuelas a largo plazo relacionados con la enfermedad (11).…”

Section: Discussionunclassified

Trombosis séptica de senos cavernosos secundaria a celulitis facial

Ramírez

Arce

2020

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La trombosis séptica del seno cavernoso es una enfermedad rara que se presenta como una tromboflebitis en el seno cavernoso como complicación posterior a infecciones faciales, principalmente en la zona denominada zona de peligro ( tercio medio de la cara , alrededor de ojos y nariz ) zona que drena en la venas oftálmicas; además ,rinosinusitis (especialmente esfenoiditis y etmoiditis, celulitis, abscesos ,otitis media, , faringitis y con menos frecuencia infecciones dentales(1). Se puede presentar como un cuadro agudo que puede ser dramático y potencialmente mortal sin embargo en raras ocasiones se presenta como un cuadro subagudo o crónico. Su elevada morbimortalidad amerita que se realice un diagnóstico rápido y certero que evite secuelas graves. Se presenta el caso de un hombre que acude al servicio de emergencias con cuadro agudo de fiebre, eritema, dolor a nivel nasal y salida de secreción purulenta posterior a trauma punzante que posteriormente se diagnostica una trombosis séptica bilateral de senos cavernosos secundaria a una celulitis facial.

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Cavernous sinus thrombosis due to ipsilateral sphenoid sinusitis

Cited by 20 publications

References 14 publications

Complications of COVID-19 in the maxillo-facial region: Clinical case and review of the literature

Complications of COVID-19 in the maxillo-facial region: Clinical case and review of the literature

Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Trombosis séptica de senos cavernosos secundaria a celulitis facial

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