Caveolin as a Universal Target in Dermatology

Abstract

Caveolin-1 is strongly expressed in different dermal and subdermal cells and physically interacts with signaling molecules and receptors, among them with transforming growth factor beta (TGF-β), matrix metalloproteinases, heat shock proteins, toll-like and glucocorticoid receptors. It should therefore be heavily involved in the regulation of cellular signaling in various hyperproliferative and inflammatory skin conditions. We provide an overview of the role of the caveolin-1 expression in different hyperproliferative and inflammatory skin diseases and discuss its possible active involvement in the therapeutic effects of different well-known drugs widely applied in dermatology. We also discuss the possible role of caveolin expression in development of the drug resistance in dermatology. Caveolin-1 is not only an important pathophysiological factor in different hyperproliferative and inflammatory dermatological conditions, but can also serve as a target for their treatment. Targeted regulation of caveolin is likely to serve as a new treatment strategy in dermatology.

A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

“…In this context, the plasma membrane of eHFSCs, namely its caveolae and their principal structural component, caveolin-1 (Cav1) [ 49 , 50 ], has not yet been considered. Cav1 compartmentalizes various signal transduction molecules and thus orchestrates numerous transmembrane signaling events involved in epithelial cell function including (but not limited to) endocytosis, lipid transport, signal transduction, inflammation, as well as cellular migration and proliferation ( Figure 1 b) (reviewed in [ 3 ]).…”

“…[ 49 , 54 ]. Although a few recent studies have begun to characterize expression and the potential functional role of Cav1 in skin epithelium [ 50 , 55 , 56 , 57 , 58 , 59 , 60 ], its role in human hair physiology remains entirely unknown. Here, we argue that Cav1 deserves special scrutiny and therapeutic targeting in future PLCA management, namely in the treatment of FFA.…”

Assessment of Mechanical Stress Induced by Radiofrequency Currents on Skin Interfaces

“…This protein is strongly involved in rapid adaptation to cellular volume modifications, in multiple signal transduction processes, and in the processes of endo- and exocytosis as well as in intercellular adhesion. Modulation of Cav-1 can be provided both by a mild hyperthermia and/or mechanical stimulation, and it was considered as an important target in different inflammatory and hyperproliferative dermatological conditions as well as in prevention and therapy of skin aging [ 17 , 18 ]. Moreover, Cav-1 is an important component of intercellular adhesion [ 18 ] and thus is strongly involved in mechanical properties of the cells and tissues.…”

“…Modulation of Cav-1 can be provided both by a mild hyperthermia and/or mechanical stimulation, and it was considered as an important target in different inflammatory and hyperproliferative dermatological conditions as well as in prevention and therapy of skin aging [ 17 , 18 ]. Moreover, Cav-1 is an important component of intercellular adhesion [ 18 ] and thus is strongly involved in mechanical properties of the cells and tissues. Its content can be modified yet by application of the low-level mechanical stresses of about 1 Pa [ 19 ], which are in the range of the pressures induced on the skin interfaces by RF currents (Tables 3 and 4 ), and this expression increases with increased stress.…”

<p>Acoustic Waves in Axonal Membrane and Caveolins are the New Targets for Pain Treatment with High Frequency Ultrasound</p>

“…Peroxisome proliferatoractivated receptor gamma (PPARγ) demonstrates protective effect in osteoarthritis in vivo; 40 on the other hand, PPARγ and its agonists are the known positive regulators of Cav-1 in different types of cells. 41,42 Such interaction corresponds to a generally positive effect of Cav-1 induction in inflammatory conditions 43 and indicates that Cav-1 modulation can be a target in osteoarthritic pain.…”