Caveolin-1 in skin aging – From innocent bystander to major contributor

Kruglikov, Ilja L.; Zhang, Zhuzhen; Scherer, Philipp E.

doi:10.1016/j.arr.2019.100959

Cited by 27 publications

(28 citation statements)

References 93 publications

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“…In this study, we observed that the dWAT volume negatively correlated with the thickness of the dermis in different mouse models ( Figure 1). Such negative correlations were earlier observed in chronological ageing [20] and clearly indicate that the dermis and dWAT are two sub-layers of the same skin layer. Given that the largest component of dermis is the ECM, and fibroblasts are the predominant cell type responsible for ECM production, we investigated the contribution of dWAT to the metabolism of dermal fibroblasts.…”

Section: Discussionsupporting

confidence: 77%

Dermal adipocytes contribute to the metabolic regulation of dermal fibroblasts

Zhang

Kruglikov²,

Zhao

et al. 2020

Experimental Dermatology

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Dermal fibroblasts are an essential population of skin cells. They are not only responsible for synthesis and remodelling of the extracellular matrix of the dermis, but also communicate with other skin cells via autocrine and paracrine interactions. Skinassociated dermal adipocytes reside below the reticular dermis. Strong lipolysis is observed during the regression of dermal adipocytes. However, the nature of the local intercellular crosstalk in which lipids released by dermal adipocytes affecting the metabolism of adjacent skin fibroblasts has not yet been examined. With the use of a series of novel mouse models that allow us to manipulate adipocytes, we demonstrate that dermal adipocytes can modulate the structure of the dermis through regulating extracellular matrix production in dermal fibroblasts. Fatty acids released by dermal adipocytes are involved in this process. Our observations offer new in vivo insights into the role of dermal adipocyte-derived lipids in influencing metabolism of adjacent local cells in the skin through a paracrine effect in the microenvironment of the dermal adipocyte.

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Section: Discussionsupporting

confidence: 77%

Dermal adipocytes contribute to the metabolic regulation of dermal fibroblasts

Zhang

Kruglikov²,

Zhao

et al. 2020

Experimental Dermatology

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“…[191] For further comprehensive description on the role of Cav1 in macro-and mesoscopic alterations during in skin ageing and other ageing-related diseases, please refer to previously published review articles. [192,193] With further investigation, targeting Cav1 could potentially be beneficial in decelerating skin ageing and thus used for cosmetic purposes in the future as well.…”

Section: Role Of C Av1 In Cellul Ar S Ene Scen Ce and S K In Ag Eingmentioning

confidence: 99%

The importance of caveolins and caveolae to dermatology: Lessons from the caves and beyond

Egger

Rajabi‐Estarabadi

Williams

et al. 2020

Experimental Dermatology

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Caveolae are flask‐shaped invaginations of the cell membrane rich in cholesterol and sphingomyelin, with caveolin proteins acting as their primary structural components that allow compartmentalization and orchestration of various signalling molecules. In this review, we discuss how pleiotropic functions of caveolin‐1 (Cav1) and its intricate roles in numerous cellular functions including lipid trafficking, signalling, cell migration and proliferation, as well as cellular senescence, infection and inflammation, are integral for normal development and functioning of skin and its appendages. We then examine how disruption of the homeostatic levels of Cav1 can lead to development of various cutaneous pathophysiologies including skin cancers, cutaneous fibroses, psoriasis, alopecia, age‐related changes in skin and aberrant wound healing and propose how levels of Cav1 may have theragnostic value in skin physiology/pathophysiology.

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“…The hippocampus of aged mice shows low Cav-1 expression, and knocking it out triggers a predisposition to an early Alzheimer's disease-like phenotype (Head et al, 2010). Total rat brain levels of Cav-1 are decreased in aged animals (Yang et al, 2018), and skin fibroblasts upregulate Cav-1 in both chronological and UV-induced skin aging (Kruglikov et al, 2019).…”

Section: Ehrlichia Chaffeensismentioning

confidence: 99%

Caveolae as Potential Hijackable Gates in Cell Communication

Dudău

Codrici

Tănase

et al. 2020

Front. Cell Dev. Biol.

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Caveolae are membrane microdomains described in many cell types involved in endocytocis, transcytosis, cell signaling, mechanotransduction, and aging. They are found at the interface with the extracellular environment and are structured by caveolin and cavin proteins. Caveolae and caveolins mediate transduction of chemical messages via signaling pathways, as well as non-chemical messages, such as stretching or shear stress. Various pathogens or signals can hijack these gates, leading to infectious, oncogenic and even caveolin-related diseases named caveolinopathies. By contrast, preclinical and clinical research have fallen behind in their attempts to hijack caveolae and caveolins for therapeutic purposes. Caveolae involvement in human disease is not yet fully explored or understood and, of all their scaffold proteins, only caveolin-1 is being considered in clinical trials as a possible biomarker of disease. This review briefly summarizes current knowledge about caveolae cell signaling and raises the hypothesis whether these microdomains could serve as hijackable "gatekeepers" or "gateways" in cell communication. Furthermore, because cell signaling is one of the most dynamic domains in translating data from basic to clinical research, we pay special attention to translation of caveolae, caveolin, and cavin research into clinical practice.

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Caveolin-1 in skin aging – From innocent bystander to major contributor

Cited by 27 publications

References 93 publications

Dermal adipocytes contribute to the metabolic regulation of dermal fibroblasts

Dermal adipocytes contribute to the metabolic regulation of dermal fibroblasts

The importance of caveolins and caveolae to dermatology: Lessons from the caves and beyond

Caveolae as Potential Hijackable Gates in Cell Communication

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