CaV1.1 voltage-sensing domain III exclusively controls skeletal muscle excitation-contraction coupling
Simone Pelizzari,
Martin C. Heiss,
Monica L. Fernández-Quintero
et al.
Abstract:Skeletal muscle contractions are initiated by action potentials, which are sensed by the voltage-gated calcium channel (CaV1.1) and are conformationally coupled to calcium release from intracellular stores. Notably, CaV1.1 contains four separate voltage-sensing domains (VSDs), which activate channel gating and excitation-contraction (EC-) coupling at different voltages and with distinct kinetics. Here we show that a single VSD of CaV1.1 controls skeletal muscle EC-coupling. Whereas mutations in VSDs I, II and … Show more
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