Causes of sudden natural death in infancy and childhood

Berry, C. L.

doi:10.1007/978-1-4899-7160-9_11

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…These reaction patterns in group A indicate inflammatory stress [15] but are obviously not compatible with a rapidly overwhelming infection leading to death. It must be supposed that not only foudroyant infection may precede a measurable immune response [33]. Also minor inflammatory changes in "typical SIDS cases" seem to be characterized by detectable immune response and may contribute to some cot deaths [34,35].…”

Section: Discussionmentioning

confidence: 99%

Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)

Bajanowski

Ortmann

Hernández

et al. 1997

International Journal of Legal Medicine

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In 50 cases of sudden infant death cervical, paratracheal and lung hilar lymph nodes, the thymus and the spleen were investigated by histology and immunohistochemistry (CD 20, 21, 45RO). The cases were divided into 3 groups based on autopsy findings including extensive histology: A --without pathological changes (N = 12), B --with minimal to intermediate inflammation (N = 23) and C --with severe inflammation (N = 15). In accordance with previous results the frequency of "pathological" lymph node changes, such as paracortical lymphoid hyperplasia and variegated hyperplasia of the pulp increased from group A to group C. The B-cell antigens reacted accordingly. A pronounced lymphodepletation of the thymus as a sign of a long lasting stimulation of the T-cell system was also observed increasingly from group A to C. In summary, in none of the cases results obtained were indicative of a defect of the T- or B-cell system. The results in group A seem to indicate that changes in the reaction pattern of the lymphoid tissues could be a more sensitive method of detection of early stages of inflammation than local histology.

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Section: Discussionmentioning

confidence: 99%

Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)

Bajanowski

Ortmann

Hernández

et al. 1997

International Journal of Legal Medicine

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Nongenotoxic or Epigenetic Carcinogenesis

Powell¹,

Berry

2009

General, Applied and Systems Toxicology

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Carcinogens are considered nongenotoxic where they cannot be shown to interact directly with DNA in a number of short‐term screening assays, but which are capable of producing tumours in laboratory rodents in bioassays. Epigenetic events, either acting alone or in concert with genetically determined events, may produce tumours. A key feature is that dose‐threshold effects may be identifiable. In both the rat and the mouse, the liver is the most common site of nongenotoxic carcinogenesis. A special sort of hepatic carcinogenesis is that produced in rodents by peroxisome proliferators; this is of questionable significance for humans. Other important sites of non‐genotoxic carcinogenesis include endocrine glands notably the thyroid, bladder and, in the rat, the forestomach. Carcinoid tumours are tumours of the diffuse neuroendocrine cell populations, found particularly in the gastrointestinal tract. Their incidence is increased with certain drugs, notably the histamine H2 antagonists. Haemangiosarcoma, which may occur at a variety of sites, clearly arises by a number of mechanisms, some of which may be genotoxic. Mesothelioma, most often of the pleura, as a human response to asbestos, may be considered a form of non‐genotoxic carcinogenesis.

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Causes of sudden natural death in infancy and childhood

Cited by 2 publications

References 22 publications

Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)

Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)

Nongenotoxic or Epigenetic Carcinogenesis

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