Causes of reversible nephrogenic diabetes insipidus: A systematic review

Garofeanu, Camelia G.; Mr, Weir; Rosas‐Arellano, M. Patricia; Henson, Garth; Garg, Amit X.; Clark, William F.

doi:10.1053/j.ajkd.2005.01.008

Cited by 111 publications

(68 citation statements)

References 85 publications

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“…However, most NDI is not inherited, but rather results from either exogenous causes (e.g. lithium, demeclocycline) or renal disease [73,74]. In pediatric patients, NDI be a concomitant of obstructive uropathy [3,75].…”

Section: Nephrogenic Diabetes Insipidus (Ndi)mentioning

confidence: 99%

Diabetes Insipidus: A Review

Shapiro¹

2013

J Diabetes Metab

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Section: Nephrogenic Diabetes Insipidus (Ndi)mentioning

confidence: 99%

Diabetes Insipidus: A Review

Shapiro¹

2013

J Diabetes Metab

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“…The high load of calcium that needed to be excreted could have led to nephrogenic diabetic insipidus and polydipsia to compensate for the increased fluid loss. In a systematic review of causes of reversible nephrogenic diabetes insipidus by Garofeanu et al, 16 hypercalcemia as a cause of polyuria was noted. There was no association between constipation and hypercalcemia or hypercalciuria in our study.…”

Section: Discussionmentioning

confidence: 99%

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

et al. 2015

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Hypercalcemia and hypercalciuria secondary to immobilization can be occasionally severe, producing an array of symptoms. This study looked at possible determinants of hypercalcemia and hypercalciuria in immobilized trauma patients. This is a prospective observational study carried out over a period of 7 months. Fifty-five immobilized trauma patients were evaluated weekly for 4 weeks for symptoms of hypercalcemia, total serum calcium and 24-h urinary calcium. The number of limbs immobilized had a significant relationship with hypercalcemia at the end of week 1 (Po0.001) and week 4 (P ¼ 0.008) and with hypercalciuria at the end of week 1 only (Po0.001). The number of bones fractured also had a significant relationship with hypercalcemia at the end of week 1 (P ¼ 0.005) and week 4 (P ¼ 0.019), as well as with hypercalciuria at the end of week 1 (Po0.001) and week 2 (P ¼ 0.036). Weight loss was significantly associated with hypercalcemia at the end of week 4 (P ¼ 0.014) and with hypercalciuria at the end of week 3 (Po0.001) and week 4 (Po0.001), whereas polyuria and polydipsia had a significant association with hypercalciuria at the end of week 2 (Po0.001) and week 3 (P ¼ 0.030). The number of limbs immobilized and bones fractured showed an early significant relationship with the development of hypercalcemia and hypercalciuria. Weight loss showed late association with hypercalcemia and hypercalciuria, whereas polyuria and polydipsia showed early association with hypercalciuria.

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“…Acquired nephrogenic DI is typically related to either AVP resistance at the site of action in the distal tubule or collecting ducts or interference in the medullary countercurrent mechanism, causing impaired renal concentrating capacity. Lithium toxicity and metabolic abnormalities, particularly hypokalemia and hypercalcemia, are the most common causes of acquired nephrogenic DI, but numerous other etiologies have been implicated 82 (Table 6). Long-term lithium therapy can lead to polyuria and impaired renal concentrating defects in an estimated 20-30% of patients and DI in 10-12% of patients, due to the down-regulation of AVP-2 receptors and/or reduced expression of AQP-2 channels.…”

Section: Diabetes Insipidusmentioning

confidence: 99%

Les troubles de l’équilibre hydrosodé chez les patients hospitalisés

Bagshaw

Townsend

McDermid

2008

Can J Anesth/J Can Anesth

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Purpose To review and discuss the epidemiology, contributing factors, and approach to clinical management of disorders of sodium and water balance in hospitalized patients. Source An electronic search of the MEDLINE, Embase, and Cochrane Central Register of Controlled Trials databases and a search of the bibliographies of all relevant studies and review articles for recent reports on hyponatremia and hypernatremia with a focus on critically ill patients. Principal findings Disorders of sodium and water balance are exceedingly common in hospitalized patients, particularly those with critical illness and are often iatrogenic. These disorders are broadly categorized as hypo-osmolar or hyper-osmolar, depending on the balance (i.e., excess or deficit) of total body water relative to total body sodium content and are classically recognized as either hyponatremia or hypernatremia. These disorders may represent a surrogate for increased neurohormonal activation, organ dysfunction, worsening severity of illness, or progression of underlying chronic disease. Hyponatremic disorders may be caused by appropriately elevated (volume depletion) or inappropriately elevated (SIADH) arginine vasopressin levels, appropriately suppressed arginine vasopressin levels (kidney dysfunction), or alterations in plasma osmolality (drugs or body cavity irrigation with hypotonic solutions). Hypernatremia is most commonly due to unreplaced hypotonic water depletion (impaired mental status and/or access to free water), but it may also be caused by transient water shift into cells (from convulsive seizures) and iatrogenic sodium loading (from salt intake or administration of hypertonic solutions). Conclusion In hospitalized patients, hyponatremia and hypernatremia are often iatrogenic and may contribute to serious morbidity and increased risk of death. These disorders require timely recognition and can often be reversed with appropriate intervention and treatment of underlying predisposing factors.

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Causes of reversible nephrogenic diabetes insipidus: A systematic review

Cited by 111 publications

References 85 publications

Diabetes Insipidus: A Review

Diabetes Insipidus: A Review

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients

Les troubles de l’équilibre hydrosodé chez les patients hospitalisés

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