Causes of Prematurity

Aims:Although a previous study found high risk of breast cancer in mothers of children with soft tissue sarcomas, breast cancer risks in mothers of sufferers of other childhood cancers largely remain unknown. The aetiology is not fully understood. The present study explored this excess by varying type of childhood solid cancer and formulated a hypothesis.Methods:Mothers of 2668 children with solid tumours included in the Manchester Children’s Tumour Registry, 1954–96, were traced and followed up to 31 December 2000 through the UK National Health Service Central Register. Standardized incidence ratio (SIR), p-values and 95% confidence intervals were calculated from age and calendar-year-specific female breast cancer incidence rates for England and Wales.Results:There was a significant excess of breast cancer in mothers overall (SIR=1.3, 95%CI=1.0–1.5) mainly due to mothers of children with rhabdomyosarcoma (RMS) (SIR=2.2, 95%CI=1.0–4.0), skin cancer (SIR=7.9, 95%CI=2.9–17.1) and central nervous system tumours (SIR=1.2, 95%CI=0.9–1.8). Maternal breast cancer risk was associated with late age at birth of the index child, and male sex and young age at diagnosis in the index child. Risk was highest in the ten years, following the birth of the index. The pattern was seen most strongly in mothers of children with embryonal RMS.Conclusion:There are excesses of breast cancer in mothers of children with solid tumours in general and specifically in RMS, skin and central nervous system (CNS). There appears to be a temporal relationship between certain tumours in children and breast cancer in their mothers, suggesting an origin of their respective pregnancy. We propose a mother–foetal interaction mechanism to explain this association.

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“…Male foetuses grow faster and males have higher average birth weight but shorter gestations than girls [19, 20]. …”

Section: Discussionmentioning

confidence: 99%

Elevated breast cancer risk among mothers of a population-based series of 2668 children with cancer

Pang

Evans²,

Birch³

2009

ecancer

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Iv. Influence of Maternal Illness on the Incidence of Prematurity; Employment of a New Criterion of Prematurity for the Negro Race

Brown¹

1945

Arch Pediatr Adolesc Med

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Dietary and Storage Factors in Iron-Deficiency Anemia of Infancy

Dawson¹,

Desforges²,

DeLuca³

et al. 1958

Arch Pediatr Adolesc Med

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With the Technical Assistance of Frances DeLuca, B.S., and Alice Manchester, B.S. Several factors are thought to contribute to the iron-deficiency anemia of infancy. Included among these are decreased dietary iron, inadequate iron stores at birth, and excessively rapid growth. This study was undertaken to evaluate the relative importance of these factors. Methods and MaterialsThe peripheral blood was studied in all infants, as previously described,1 with the exception of some hemoglobin determinations, which were measured with use of a modification of the cyanomethemoglobin method.2 Serum iron and iron-binding capacity were measured by the method

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Causes of Prematurity

Cited by 50 publications

References 4 publications

Elevated breast cancer risk among mothers of a population-based series of 2668 children with cancer

Elevated breast cancer risk among mothers of a population-based series of 2668 children with cancer

Iv. Influence of Maternal Illness on the Incidence of Prematurity; Employment of a New Criterion of Prematurity for the Negro Race

Dietary and Storage Factors in Iron-Deficiency Anemia of Infancy

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