Causes of patient loss during clinical trials: a meta-epidemiological study

Tabares, Daniela Hincapié; Carrillo, Vanessa Pérez; Gómez, Jorge Hernando Donado

doi:10.14482/sun.35.1.614.4

Cited by 1 publication

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“…In our work, 7351 people began the intervention with losses during its development of 317 people. Ultimately, this study had a completion rate of 95.69% of the initial sample compared to 4.31% losses, which we consider very low, since, in the published literature, losses range around 20% [117][118][119].…”

Section: Discussionmentioning

confidence: 97%

The Effect of a Program to Improve Adherence to the Mediterranean Diet on Cardiometabolic Parameters in 7034 Spanish Workers

Ramírez Gallegos,

Marina Arroyo,

López-González

et al. 2024

Nutrients

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Background: Cardiovascular and metabolic diseases include a large group of pathologies and constitute one of the most serious chronic health problems facing the 21st century, with high rates of morbidity and mortality worldwide. Unhealthy diets influence the development of these pathologies. The Mediterranean diet can be an important part in the treatment of these diseases. The objective of this study was to assess the effect of a program that aims to increase adherence to the Mediterranean diet on the improvement of different cardiometabolic risk parameters. Methods: A prospective intervention study was carried out on 7034 Spanish workers. Prior to the intervention, 22 cardiometabolic risk scales were evaluated. Participants in this study were informed both orally and in writing of the characteristics and benefits of the Mediterranean diet and were given the website of the Ministry of Health, Consumption and Social Welfare of Spain, which provides advice on nutrition. Adherence to the Mediterranean diet was reinforced by sending a monthly SMS to their mobile phones. After six months of follow-up, the 22 risk scales were re-evaluated to assess changes. Means and standard deviations were calculated using Student’s t test to analyse quantitative variables. Prevalence was calculated using the Chi-square test when the variables were qualitative. Results: All the cardiometabolic risk scales studied decreased after implementing a program to improve and enhance adherence to the Mediterranean diet. The number of losses in the sample was very low, standing at 4.31%. Conclusions: The Mediterranean diet is effective in reducing all cardiovascular risk scales evaluated. The mean values and prevalence of high values of the different cardiometabolic risk scales analysed led to lower values after the implementation of the program to increase adherence to the Mediterranean diet. We observed a significant positive difference in metabolic age in both sexes. We have obtained a significant improvement in the insulin resistance index, especially in the SPISE-IR index, data that we have not found in previous publications. Easy access to the Internet and new information and communication technologies facilitate adherence to a diet and can reduce the number of losses.

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Section: Discussionmentioning

confidence: 97%