Causes of Male Infertility

Wiser, Herbert J.; Sandlow, Jay; Köhler, Tobias

doi:10.1007/978-1-4614-3335-4_1

Cited by 14 publications

(4 citation statements)

References 138 publications

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“…Male infertility is a multi-factorial condition caused by gene mutations, chromosomal abnormalities, infectious diseases, varicocele, recurrent duct occlusion, radiation, and chemotherapy 12. However, in 50% of the cases, there is no identifiable cause of infertility and this condition is termed as idiopathic 34.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of mature and immature ejaculated spermatozoa from fertile men

2016

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Dysfunctional spermatozoa maturation is the main reason for the decrease in sperm motility and morphology in infertile men. Ejaculated spermatozoa from healthy fertile men were separated into four fractions using three-layer density gradient. Proteins were extracted and bands were digested on a LTQ-Orbitrap Elite hybrid mass spectrometer system. Functional annotations of proteins were obtained using bioinformatics tools and pathway databases. Western blotting was performed to verify the expression levels of the proteins of interest. 1469 proteins were identified in four fractions of spermatozoa. The number of detected proteins decreased according to the maturation level of spermatozoa. During spermatozoa maturation, proteins involved in gamete generation, cell motility, energy metabolism and oxidative phosphorylation processes showed increasing expression levels and those involved in protein biosynthesis, protein transport, protein ubiquitination, and response to oxidative stress processes showed decreasing expression levels. We validated four proteins (HSP 70 1A, clusterin, tektin 2 and tektin 3) by Western blotting. The study shows protein markers that may provide insight into the ejaculated spermatozoa proteins in different stages of sperm maturation that may be altered or modified in infertile men.

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Section: Introductionmentioning

confidence: 99%

Proteomic analysis of mature and immature ejaculated spermatozoa from fertile men

2016

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“…Other pretesticular causes of male infertility are coital disorders, such as ejaculatory disorders (e.g., anejaculation, retrograde ejaculation) [ 13 , 14 ] and erectile dysfunction [ 15 ]. It should be noted that some authors included coital disorders among the post-testicular causes of male infertility [ 16 ]. Post-testicular causes of male infertility also include primarily all the obstructions of the seminal tract [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

NGF and the Male Reproductive System: Potential Clinical Applications in Infertility

Ferraguti

Fanfarillo

Tarani

et al. 2022

IJMS

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Infertility is a worldwide health issue defined by the World Health Organization (WHO) as the inability to establish a pregnancy after 12 months or more of regular and unprotected sexual intercourse. Male infertility etiology can be related to either congenital or acquired factors. The therapeutical approach to male infertility depends on the underlying causes and includes medical and surgical treatments. In recent studies, the potential role of nerve growth factor (NGF) in male reproductive physiology has been proposed. It has been hypothesized that neurotrophins might be involved in testis morphogenesis and regulation of several aspects of spermatogenesis. Moreover, it has been shown that NGF exerts its role on gonadotropin-releasing hormone (GnRH) neurons through the activation of the PKC/p–ERK1/2/p–CREB cascade, which leads to the activation of hypothalamic cells and the consequent activation of hypothalamus–pituitary–gonadal axis (HPG) with the secretion of GnRH. Lastly, it has been shown that the physiology of mature sperm is affected by both exogenous and endogenous NGF. The NGF impact on the HPG axis and its effect on GnRH neurons might be exploited in the therapy of male hypogonadism or used as a protective strategy against gonadal dysfunction related to chemotherapeutic agents. Moreover, the improving effect of NGF on sperm motility and vitality could be useful to enhance assisted reproduction outcomes. NGF could be supplemented to cryopreserved sperm samples to counteract the oxidative stress induced by the frozen and thawing processes. Indeed, the potential clinical applications of NGF in male infertility treatment have been discussed.

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“…e structural abnormality and/or pelvic inflammation stops spermatozoa from traveling in the fallopian tube and subsequently fertilizing locates [3]. About half of the infertilities involve male factors, either the male factor alone or male-female combined problems, while most of the male infertility is preventable, ameliorable, or treatable [4]. Invasive tools were introduced to assist infertile couples.…”

Section: Introductionmentioning

confidence: 99%

“…FSH, follicle-stimulating hormone; LH, luteinizing hormone; BP sys., systolic blood pressure; BP dia., diastolic blood pressure; DBIL, direct bilirubin; BUN, blood urea nitrogen; PR, progressive; NP, nonprogressive; SFN, small follicle number in ovaries; ORN, oocyte retrieved number. Level a sperm: fast-moving sperms; Level b sperm: slowly moving sperms 4. Evidence-Based Complementary and Alternative Medicine predicted accuracy.…”

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confidence: 99%

Follicular Metabolites-Assisted Clinical Evaluation of IVF/ICSI Outcomes

Xiong

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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As infertility became a significant public health problem, assisted reproductive technologies (ARTs) were introduced. However, the fertilization rate of in vitro fertilization (IVF) per cycle varied, and patients needed to repeat IVF or change to intracytoplasmic sperm injection (ICSI). Here, 75 couples suffering from female fallopian tubal blockage (tubal group) and 42 spouses beset by male abnormal sperm status (dysspermia group) were recruited. We comprehensively explored the relationship among couples’ clinical factors, follicular metabolites, and IVF/ICSI stepwise outcomes. IVF/ICSI outcomes were affected by follicular metabolites and physical status in both women and men, regardless of which side infertility came from. Particularly, in the tubal group, the energy supporting pathways—glycolysis and pyruvate metabolism—were most essential in follicles, and IVF/ICSI outcomes were also related to sperm parameters. However, in the dysspermia group, in addition to sperm conditions, oocyte quality acted as a compensation for poor sperm quality, for which aminoacyl-tRNA biosynthesis and the related supporting metabolism were critical in the follicular environment, and ultimately played a decisive role in IVF/ICSI outcomes. The respective logistic regression models in combination with selective male sperm parameters, estradiol (E2), follicular alanine, glutamine, glycoprotein, lipid, and acetic acid, were constructed to predict IVF or ICSI outcomes. No matter which sex infertility comes from, factors from both men and women should be considered. The current study provides a feasible option for pre-IVF evaluation, as well as guidance for follow-up clinical intervention to improve IVF/ICSI success rates.

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Causes of Male Infertility

Cited by 14 publications

References 138 publications

Proteomic analysis of mature and immature ejaculated spermatozoa from fertile men

Proteomic analysis of mature and immature ejaculated spermatozoa from fertile men

NGF and the Male Reproductive System: Potential Clinical Applications in Infertility

Follicular Metabolites-Assisted Clinical Evaluation of IVF/ICSI Outcomes

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