Causes of Hypothyroidism

Kostić, Irena; Curcio, Francesco

doi:10.5772/32571

Cited by 6 publications

(3 citation statements)

References 70 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Вследствие недостаточной секреции тиреоидных гормонов происходит повышение секреции TТГ гипофизом. Это может быть результатом недостаточного количества тиреотропин-рилизинг гормона (TРГ), поступающего из гипоталамуса [28]. Согласно исследованию А. Roos, уровень AТ-TПO коррелирует с уровнем TТГ для прогнозирования развития гипо-/гипертиреоза.…”

Section: Discussionunclassified

Autoimmune thyroiditis in different age groups and subjects of reproductive age in Adzhariya population

Tchelidze

Glonti

Baratashvili

et al. 2022

Akušerstvo, ginekologiâ i reprodukciâ

View full text Add to dashboard Cite

Introduction. Autoimmune thyroiditis (AIT) is the most prevalent among the autoimmune pathologies and multifactorial thyroid diseases; accordingly, remaining a pressing issue for investigation.Aim: to study AIT profile in different age groups of the female population in the western region of Georgia – Adzhariya.Materials and Methods. A prospective comparative study in parallel groups was carried out. There were examined 405 samples of venous blood obtained at «Health» Clinic from women of two groups: group 1 – 159 patients with AIT, group 2 (control) – 246 women without AIT. Blood samples were collected between the years 2017 and 2020. There were analyzed serum antibodies against thyroperoxidase (TPOAb), thyroid stimulating hormone (TSH) as well as level of free thyroxine (FT4) by using enzyme immunoassay.Results. Patients with AIT from different age groups vs. control group were found to have decreased level of FT4, but increased amount of TSH and TPOAb. At the reproductive age (18–45 years), a significant increase in the level of TSH was found (6.12 times) compared with the control group (p < 0.0001). The level of FT4 and TSH in AIT women aged 51 to 60 years was 0.7880 ± 0.3584 ng/ml and 4.754 ± 2.433 U/ml that significantly differed from those in the control group – 1.314 ± 0.4044 ng/ml (p < 0.0001) and 2.276 ± 1.409 U/ml (p < 0.0001), respectively.Conclusion. AIT occurs in women of all age groups, but is more common in women aged 51 to 60 years. In a number of cases, TPOAb was detected in the control group, which, apparently, is associated with increased intake of dietary iodized salt since 2005 in Georgia (the adoption of the law on universal salt iodization). A significant increase in the level of TSH, in AIT women aged 18–45 years, strongly suggests to perform diagnostics of and screening for AIT not only in females of menopausal period, but also in reproductive age.

show abstract

Section: Discussionunclassified

Autoimmune thyroiditis in different age groups and subjects of reproductive age in Adzhariya population

Tchelidze

Glonti

Baratashvili

et al. 2022

Akušerstvo, ginekologiâ i reprodukciâ

View full text Add to dashboard Cite

show abstract

“…Low vitamin D levels may be implicated in the pathogenesis of autoimmune thyroid disease. According to several case-control studies that patients with AITDs have lower blood vitamin D levels or a higher prevalence of vitamin D deficiency than healthy controls (3,5). Another research showed no difference between vitamin D levels in the blood and thyroid autoimmunity (4).…”

Section: Introductionmentioning

confidence: 99%

The relation between vitamin D insufficiency and thyroid hormones in Iraqi women living in Al-Khalidiya, Anbar Province

Raeef,

Al-Shaabani,

Al-Ani

2023

JoBRC

View full text Add to dashboard Cite

Background: Vitamin D insufficiency is a worldwide issue in all age groups. It wasdiscovered that vitamin D insufficiency is linked to autoimmune disorders such as Irritablebowel illness, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, andrheumatoid arthritis. Vitamin D is also connected to the development of thyroid autoimmunedisease and plays an important role in endocrinopathies including type 1 and type 2 diabetes,adrenal diseases, and polycystic ovarian syndrome.Materials and methods: 100 samples were collected for women from Al-Khalidiya city inAnbar province (50 samples likely to have thyroid problems, 50 healthy samples). The levelsof vitamin D and thyroid hormones were measured using A Minividus system (whichcombines a two-step enzyme sands assay with an ELFA, or End Fluorescent DetectionMethod).Results: The current findings revealed that there are significant variations in vitamin D andT4 levels between patients and healthy controls ( P-value 0.05). There is also a positiveassociation between vitamin D levels and T4 (r = 0.378, P-value = 0.007), as well as anegative correlation between vitamin D levels and TSH (r = -0.373, P-value = 0.008).Conclusion: According to our result, Individuals with hypothyroidism in Alkhaldia have avitamin D3 deficiency. In addition, blood vitamin D levels show a positive correlation with T4and a negative correlation with TSH levels. To avoid developing osteoporosis ifhypothyroidism persists, all hypothyroid Iraqi patients should be checked for Vitamin Ddeficiency.

show abstract

“…It is unclear whether low vitamin D levels are closely associated with the development of autoimmune thyroid disease. Some case-control studies have suggested that lower serum vitamin D levels or a higher prevalence of vitamin D insufficiency existed in patients with AITDs compared with that in healthy controls [3, 5]. Another study reported no significant association between serum vitamin D levels and thyroid autoimmunity [4].…”

Section: Introductionmentioning

confidence: 99%

Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients

Elrawi

Ghanem

Elsayed

et al. 2019

Journal of Thyroid Research

View full text Add to dashboard Cite

Purpose. The current study aimed at assessing vitamin D level and vitamin D receptor polymorphism in hypothyroid Egyptian patients and its effect on hypothyroidism and thyroid morphology, also to find a causal relation between vitamin D and hypothyroidism. Methods. This case-control study was conducted on 35 hypothyroid patients and 35 matched unrelated healthy controls. Total serum 25-hydroxyvitamin D3 and thyroid antibodies were measured using a human ELISA kit. Genotyping was performed by using real-time PCR. HOMA-IR was also calculated (fasting insulin in mIU/L × fasting glucose in mg/dL/405). All subjects were assessed for thyroid morphology by thyroid ultrasonography. Results. Vitamin D level was lower in hypothyroid patients than in control subjects. Vitamin D was also inversely related to TSH, HOMA-IR, and levels of anti-TG and anti-TPO. VDR polymorphism (Fok1 and Apa1) had no relation to TSH or vitamin D levels in both patients and control groups. Low vitamin D levels were associated with increased thyroid vascularity and nodularity; furthermore, vitamin D was inversely proportional to thyroid gland volume. Correlation of HOMA-IR with the levels of both anti-TG and anti-TPO in the 70 subjects proved that HOMA-IR was positively correlated to both antibodies. Conclusion. This study confirmed the association of vitamin D deficiency with hypothyroidism, thyroid autoimmunity, increased volume, nodularity, and vascularity of thyroid gland in hypothyroid patients as well as increased HOMA-IR. It proved the association between HOMA-IR and thyroid autoimmunity. The study proved no association between VDR polymorphisms (Fok1 and Apa1) with either vitamin D levels or TSH levels.

show abstract

Causes of Hypothyroidism

Cited by 6 publications

References 70 publications

Autoimmune thyroiditis in different age groups and subjects of reproductive age in Adzhariya population

Autoimmune thyroiditis in different age groups and subjects of reproductive age in Adzhariya population

The relation between vitamin D insufficiency and thyroid hormones in Iraqi women living in Al-Khalidiya, Anbar Province

Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients

Contact Info

Product

Resources

About