Causes of hypercalcemia in renal transplant recipients: persistent hyperparathyroidism and others

Timing of parathyroidectomy for kidney transplant patients with secondary hyperparathyroidism: A practical overview

“…Studies have noted a significant correlation between PTH and the estimated glomerular filtration rate (eGFR) (12,13). With the restoration of a more normal eGFR, SHPT might resolve in mild cases or remain stable until the end of the first year post-transplant (11,14). Even with adequate allograft function, PHPT is still observed in 30-60% of kidney transplant recipients 1 year after KT and in 20% of patients even at 5 years (4,14,15).…”

“…With the restoration of a more normal eGFR, SHPT might resolve in mild cases or remain stable until the end of the first year post-transplant (11,14). Even with adequate allograft function, PHPT is still observed in 30-60% of kidney transplant recipients 1 year after KT and in 20% of patients even at 5 years (4,14,15). The direct and most prominent impact of PHPT is on the serum calcium level (12,14).…”

“…Even with adequate allograft function, PHPT is still observed in 30-60% of kidney transplant recipients 1 year after KT and in 20% of patients even at 5 years (4,14,15). The direct and most prominent impact of PHPT is on the serum calcium level (12,14). Although the serum calcium level normalizes a few days after KT, hypercalcemia may develop as soon as 1 week after transplantation (7,14).…”

“…The direct and most prominent impact of PHPT is on the serum calcium level (12,14). Although the serum calcium level normalizes a few days after KT, hypercalcemia may develop as soon as 1 week after transplantation (7,14). Hypercalcemia is closely associated with PHPT in the majority of cases and is usually considered to be an indicator of PHPT, with a incidence between 10% and 30% (9,14,15).…”

“…Although the serum calcium level normalizes a few days after KT, hypercalcemia may develop as soon as 1 week after transplantation (7,14). Hypercalcemia is closely associated with PHPT in the majority of cases and is usually considered to be an indicator of PHPT, with a incidence between 10% and 30% (9,14,15). This variability in incidence may be attributable to various factors such as the use of different serum calcium levels for diagnosis, evaluation of the ionized or total calcium level, regardless of whether the calcium levels are corrected based on albumin, and the timing of diagnosis (15).…”